NKT cell cytokine imbalance in murine diabetes mellitus

Autoimmunity

Volumn 29, Issue 3, 1999, Pages 201-214

  Frey, Alan B ^a   Rao, T Dharma ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diabetes; Interleukin 4; NKT cells; Non obese diabetic mouse; Streptozotocin

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 5; KEYHOLE LIMPET HEMOCYANIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DIABETES MELLITUS; HELPER CELL; MOUSE; NATURAL KILLER CELL; NONHUMAN; STREPTOZOCIN DIABETES;

EID: 0032956243     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916939908998535     Document Type: Article

References (55)

1. Bach, J.-F., Insulin-dependent diabetes mellitus as an autoimmune disease. Endocrine Rev. 1994; 15: 516.
2. Delovitch, T. and Singh, B., The Nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 1998; 7: 727.
3. B.-Worrell, B., Starkebaum, G., Greenbaum, C. and Palmer, J., Peripheral blood mononuclear cells of insulin-dependent diabetic patients respond to multiple islet cell proteins. J. Immunol. 1996; 157: 5668.
4. Charlton, B. and Lafferty, K., The Th1/Th2 balance in autoimmunity. Cur. Opin. Immunol. 1995; 7: 793.
5. Rabinovich, A., Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM: Therapeutic intervention by immunostimulation. Diabetes 1994; 43: 613.
6. Sadick, M., Heinzel, F., Holaday, B., Pu, R., Dawkins, R. and Locksley, R., Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon-γ-independent mechanism. J. Exp. Med. 1990; 171: 115.
7. Romani, L., Mencacci, A., Grohmann, U., Mocci, S., Mosci, P., Pucetti, P. and Bistoni, F., Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1-associated immunity in murine candidiasis. J. Exp. Med. 1992; 176: 19.
8. Chatelain, R., Varkila, K. and Coffman, R., IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 1992; 148: 1182.
9. Baekkeskov, S., Aanstoot, H., Christgau, S., Reetz, A., Solimena, M., Cascalho, M., Folli, F., Olesen, H. and Camilli, P.D., Identification of the 64 K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nat. 1990; 347: 151.
10. Muir, A., Peck, A., Salzler, M., Song, Y.-H., Cornelius, J., Luchetta, R., Krischer, J. and Maclaren, N., Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-γ transcription. J. Clin. Invest. 1995; 95: 628.
11. Roep, B., Kallan, A., Hazenbos, W., Bruining, G., Bailyes, E., Arden, S., Hutton, J. and Vries, R.D., T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes. Lancet 1991; 337: 1439.
12. Tisch, R., Yang, X., Singer, S., Liblau, R., Fugger, L. and McDevitt, H., Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nat. 1993; 366: 72.
13. Katz, J., Wang, B., Haskins, K., Benoist, C. and Mathis, D., Following a diabetogenic T cell from genesis through pathogenesis. Cell 1993; 74: 1089.
14. Katz, J., Benoist, C. and Mathis, D., T helper cell subsets in insulin-dependent diabetes. Sci. 1995; 268: 1185.
15. Cambell, I., Kay, T., Oxbrow, L. and Harrison, L., Essential role for IFN-g and IL-6 in autoimmune insulin-dependent diabetes in NOD/WEHI mice. J. Clin. Invest. 1991; 87: 739.
16. Rapoport, M.J., Jaramillo, A., Zipris, D., Lazarus, A.H., Serreze, D.V., Leiter, E.H., Cyopick, P., Danska, J.S. and Delovitch, T.L., Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J. Exp. Med. 1993; 178: 87.
17. Campbell, I., Oxbrow, L., Koulmanda, M. and Harrison, L., IFN-g induces islet cell MHC antigens and enhances autoimmune streptozotocin-induced diabetes in the mouse. J. Immunol. 1988; 140: 1111.
18. Cockfield, S., Ramassar, V., Urmson, J. and Halloran, P., Multiple low dose streptozotocin induces systemic MHC expression in mice by triggering T cells to release IFN-γ. J. Immunol. 1989; 142: 1120.
19. Herold, K., Vezys, V., Sun. Q., Viktora, D., Seung, E., Reiner, S. and Brown, D., Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin. J. Immunol. 1996; 156: 3521.
20. Fox, C. and Danska, J., IL-4 expression at the onset of islet inflammation predicts nondestructive insulitis in nonobese diabetic mice. J. Immunol. 1997; 158: 2414.
21. Hsieh, C., Heimberger, A., Gold, J., O'Garra, A. and Murphy, K., Differential regulation of T helper phenotype by Interleukins 4 and 10 in an αβ T cell receptor transgenic system. Proc. Natl. Acad. Sci. 1992; 89: 6065.
22. Seder, R., Paul, W., Davis, M. and Groth, B.F.D.S., The presence of interleukin 4 during in vitro priming determined the lymphokin-producing potential of CD4+ T cells from T cell receptor transgenic mice. J. Exp. Med. 1992; 176: 1091.
23. Gross, A., Ben-Sasson, S. and Paul, W., Anti-IL-4 diminishes in vivo priming for antigen-specific IL-4 production by T cells. J. Immunol. 1993; 150: 2112.
24. Shehadeh, N., LaRosa, F. and Lafferty, K., Altered cytokine activity in adjuvant inhibition of autotimmune diabetes. J. Autoimmunity. 1993; 6: 291.
25. Racke, M., Bonomo, A., Scott, D., Cannella, B., Levine, A., Raine, C., Shevach, E. and Rocken, M., Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med. 1994; 180: 1961.
26. - thymocytes with specific lymphokine secretion. Eur. J. Immunol. 1993; 23: 307.
27. + T cells. Annu. Rev. Immunol. 1994; 12: 635.
28. Bendelac, A., Mouse NK1.1+ cells. Curr. Opin. Immunol. 1995; 7: 367.
29. + cells: new clues to their origin, specificity and function. J. Exp. Med. 1995; 182: 633.
30. + T cells: a new family of T cells. Immunol. Today. 1996; 17: 71.
31. Tanaka, T., Kitamura, F., Nagasaka, Y., Kuida, K., Suwa, H. and Miyasaka, M., Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor β chain monoclonal antibody in mice. J. Exp. Med. 1993; 178: 1103.
32. +-like thymocytes in the NOD mouse. Eur. J. Immunol. 1996; 26: 2989.
33. Lantz, O. and Bendelac, A., An invariant T cell receptor α chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4- 8-T cells in mice and humans. J. Exp. Med. 1994; 180: 1097.
34. Bendelac, A., Lantz, O., Quimby, M., Yewdell, J., Bennink, J. and Brutkiewicz, R., CD1 recognition by mouse NK1+ T lymphocytes. Science. 1995; 268: 863.
35. Zipris, D., Lazarus, A., Crow, A., Hadzija, M. and Delovitch, T., Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune nonobese diabetic mice. J. Immunol. 1991; 146: 3763.
36. Wood, S., Rao, T.D. and Frey, A.B., Multi-dose streptozotocin induction of diabetes in BALB/cBy mice induces a T cell receptor-mediated signaling defect in thymocytes which is reversible by interleukin-4 (submitted) 1998.
37. Berman, M., Sandborg, C., Wang, Z., Imfeld, K., Zaldivar, F., Dadufalza, V. and Buckingham, B., Decreased IL-4 production in new onset type I insulin-dependent diabetes mellitus. J. Immunol. 1996; 157, 4690.
38. pos T cells promptly produce Interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 1994; 179: 1285.
39. Herold, K., Vezys, V., Sun, Q., Victora, D., Seung, E., Reiner, S. and Brown, D., Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin. J. Immunol. 1996; 156: 3527.
40. Rabinovitch, A., Suarez-Pinzon, W., Sorensen, O., Bleackley, R. and Power, R., IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J. Immunol. 1995; 154: 4874.
41. Matyniak, J. and Reiner, S., T helper phenotype and genetic susceptibility in experimental Lyme disease. J. Exp. Med. 1995; 181: 1251.
42. Pugh, G. and Tabatabai, L., Variation in Brucella abortus 2308 infection in BALB/c mice induced by prior vaccination with salt-extractable periplasmic proteins form Brucella abortus 19. Infect. Immun. 1996; 64: 548.
43. Yoshimoto, T., Bendelac, A., H.-Li, J. and Paul, W., Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4. Proc. Natl. Acad. Sci. 1995; 92: 11931.
44. Buschard, K. and Rygaard, J., Passive transfer of streptozotocin induced diabetes mellitus with spleen cells. Acta. Path. Microbiol. Scand. Sect. C. 1977; 85: 469.
45. Buschard, K. and Rygaard, J., Is the diabetogenic effect of streptozotocin in part thymus-dependent? Acta. Path. Microbiol. Scand. Sect. C. 1978; 86: 23.
46. Herold, K., Montag, A. and Fitch, F., Treatment with anti-lymphocyte antibodies prevents induction of insulitis in mice given multiple doses of streptozotocin. Diabetes. 1987; 36: 796.
47. Herold, K.C., Bloch, T.N., Vezys, V. and Sun, Q., Diabetes induced with low doses of streptozotocin is mediated by Vβ 8.2 T-cells. Diabetes. 1995; 44: 354.
48. ras activation. J. Exp. Med. 1993; 177: 1221.
49. Kishimoto, H., Kubo, R., Yorifuji, H., Nakayama, T., Asano, Y. and Tada, T., Physical dissociation of the TCR-CD3 complex accompanies receptor ligation. J. Exp. Med. 1995; 182: 1997.
50. - T cells in non-MHC gene-controlled predisposition towards skewing into T helper type-2 immunity in BALB/c mice. J. Immunol. 1997; 158: 5698.
51. Weid, T.V.D., Beebe, A., Roopenian, D. and Coffman, R., Early production of IL-4 and induction of Th2 responses in the lymph node originate from an MHC class I-independent CD4+ NK1.1- T cell population. J. Immunol. 1966; 157: 4421.
52. Brown, D., Fowell, D., Corry, D., Wynn, T., Moskowitz, N., Cheever, A., Locksley, R. and Reiner, S., β2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses. J. Exp. Med. 1996; 184: 1295.
53. Smiley, S., Kaplan, M. and Grusby, M., Immunoglobulin E production in the absence of IL-4-secreting CD1-dependent cells. Sci. 1997; 275: 977.
54. Wogensen, L., Lee, M. and Sarvetnick, N., Production of IL-10 by islet cells accelerates immune-mediated destuction of beta cells in nonobese diabetic mice. J. Exp. Med. 1994; 179: 1379.
55. Pennline, K., R.-Gaffney, E. and Monahan, M., Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin. Immunol. Immunopathol. 1994; 71: 169.