NKT cells derive from double-positive thymocytes that are positively selected by CD1d

Nature Immunology

Volumn 2, Issue 10, 2001, Pages 971-978

  Gapin, Laurent ^a   Matsuda, Jennifer L ^a,b   Surh, Charles D ^c   Kronenberg, Mitchell ^a,b  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD1 ANTIGEN; CD1D ANTIGEN; CD4 ANTIGEN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; CELL LINEAGE; CELL MATURATION; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE REARRANGEMENT; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE SUBPOPULATION; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROLYMPHOCYTE; STOCHASTIC MODEL; T LYMPHOCYTE; THYMOCYTE;

ANIMALS; ANTIGENS, CD1; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; GALACTOSYLCERAMIDES; GENE REARRANGEMENT, ALPHA-CHAIN T-CELL ANTIGEN RECEPTOR; IMMUNOGLOBULIN JOINING REGION; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; RNA, MESSENGER; STEM CELLS; T-LYMPHOCYTE SUBSETS; THYMUS GLAND;

EID: 0034774980     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni710     Document Type: Article

References (71)

1. + cells: New clues to their origin, specificity, and function
2. Mouse CDI-specific NKI T cells: Development, specificity, and function
3. NKT cells: Facts, functions and fallacies
4. Tissue-specific segregation of CDId-dependent and CDId-independent NKT cells
5. NKT cells are phenotypically and functionally diverse
6. - single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor Vβ family
7. -T cells in mice and humans
8. +T cell populations
9. + cells in mouse liver
10. + T cells
11. CDId-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides
12. + NK T lymphocytes./
13. In vivo identification of glycolipid antigen-specific T cells using fluorescent CDId tetramers
14. Tracking the response of natural killer T cells to a glycolipid antigen using CDId tetramers
15. +T cells in major histocompatibility complex class II-deficient mice
16. Diverse TCRs recognize murine CDI
17. The mouse CDId-restricted repertoire is dominated by a few autoreactive T cell receptor families
18. - thymocytes by class I molecules expressed by hematopoietic cells
19. + thymocytes
20. + thymocytes selected by MHC class I molecules
21. + cells in the liver of mice
22. + cells
23. Positive and negative selection invoke distinct signaling pathways
24. Cutting edge: NKT cell development is selectively impaired in Fyn- deficient mice
25. The Src family tyrosine kinase Fyn regulates natural killer T cell development
26. Cutting edge: The Ets1 transcription factor is required for the development of NK T cells in mice
27. + cell development
28. Requirement for membrane lymphotoxin in natural killer cell development
29. Membrane lymphotoxin is required for the development of different subpopulations of NK T cells
30. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
31. T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice
32. Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδT cells
33. CDId-Glycolipid tetramers: A new tool to monitor natural killer T cells in health and disease
34. + T cells
35. + thymocytes
36. Identification of a naturally occurring ligand for thymic positive selection
37. A molecular map of T cell development
38. Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire
39. Assays of thymic selection. Fetal thymus organ culture and in vitro thymocyte dulling assay
40. Receptor editing in developing T cells
41. + thymocytes
42. Murine natural killer T (NKT) cells contribute to the granulomatous reaction caused by mycobacterial cell walls
43. + T cells
44. Evidence for extrathymic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation
45. + NK T cells in the early stages of embryogenesis
46. The majority of lymphocytes in the bone marrow, thymus and extrathymic T cells in the liver are generated in situ from their own preexisting precursors
47. + T cells in vitro from fetal liver precursors
48. + natural killer-T cell development
49. - murine thymocytes: passive acquisition of CD8 accessory molecules
50. low phenotype
51. Selection is not required to produce invariant T-cell receptor γ-gene junctional sequences
52. Negative selection of T cells occurs throughout thymic development
53. +T cells by CDI-expressing cortical thymocytes
54. β usage
55. - Thymocytes that express the T cell receptor may have previously expressed CD8
56. Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NKI T cells
57. The αβ T cell receptor can replace the γδ receptor in the development of γδ lineage cells
58. Premature expression of T cell receptor (TCR)αβ supresses TCRγδ gene rearrangement but permits development of γδ lineage T cells
59. + T cells selected by specific class I MHC antigen
60. + T lymphocytes: Thymic selection by self antigen
61. d
62. + T cells upon antigen expression in the thymus or in the liver
63. α14 NKT cells by granulocyte/macrophage colony-stimulating factor
64. - NK-like cells in the thymus
65. Lineage relationships and differentiation of natural killer (NK) T cells: Intrathymic selection and interleukin (IL)-4 production in the absence of NKR-PI and Ly49 molecules
66. Thymocyte selection: Not by TCR alone
67. Activation events during thymic selection
68. - Thymocytes with specific lymphokine secretion
69. + T cells are a potential source of IL-4 during primary immune response
70. +T cell development and early IL-4 production in CDI- deficient mice
71. Requirement for Vα14 NKT cells in IL-12-mediated rejection of tumors