CD1d and natural T cells: How their properties jump-start the immune system

Cellular and Molecular Life Sciences

Volumn 58, Issue 3, 2001, Pages 442-469

  Joyce, S ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anti inflammatory cytokine; CD1d; Glycolipid antigen; Granulocyte macrophage colony stimulating factor; Interferon ; Interleukin 12; Interleukin 4; Natural killer T cells; Pro inflammatory cytokines

Indexed keywords

CD1D ANTIGEN; CYTOKINE; GAMMA INTERFERON; GLYCOLIPID; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 4; LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN BINDING; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; BIOSENSOR; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; HELPER CELL; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNE SYSTEM; INFLAMMATION; LYMPHOCYTE FUNCTION; NATURAL KILLER CELL; NONHUMAN; REVIEW; T LYMPHOCYTE;

ANIMALIA;

EID: 0035083625     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000869     Document Type: Review

References (258)

1. The instructive role of innate immunity in the acquired immune response
2. Dendritic cells and the control of immunity
3. Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties
4. Functional diversity of helper T lymphocytes
5. Mouse CD1-specific NK1 T cells: Development, specificity and function
6. Phylogenetic perspectives in innate immunity
7. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
8. How MHC class II molecules acquire peptide cargo: Biosynthesis and trafficking through the endocytic pathway
9. Cytoplasmic tail dependent localization of CD1b antigen presenting molecules to MIICs
10. Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartments
11. A critical tyrosine residue in the cytoplasmic tail is important for CD1d internalization but not for its basolateral sorting in MDCK cells
12. pos T cells promptly produced IL-4 in response to in vivo challenge with anti-CD3
13. Activation of NK T cells by CD1d and α-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype
14. Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells
15. Immunization with α-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis
16. + thymocytes selected by MHC class I molecules
17. + thymocytes
18. + T cell receptor-α/β cells in the liver of mice
19. + T cells by CD1 expressing cortical thymocytes
20. + T cells
21. Positive selection of T cells
22. + T lymphocytes
23. Expression of CD1 in the mouse thymus
24. Expression of the thymus leukemia antigen in mouse intestinal epithelium
25. Structure and expression of genes encoding murine Qa-2 class I antigens
26. Expression and function of Qa-2 major histocompatibility complex class I molecules in transgenic mice
27. + T cell antigen receptor a chain in mice
28. Immunoglobulin E production in the absence of interleukin-4 secreting CD1 dependent cells
29. + T cell development and early IL-4 production in CD1 deficient mice
30. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4
31. The CD1 system: Antigen-presenting molecules for T cell recognition of lipids and glycolipids
32. Two classes of CD1 genes
33. Isolation and characterization of a cDNA and gene coding for a fourth CD1 molecule
34. Isolation and expression of cDNA encoding the murine homologues of CD1
35. Structural analysis of the rat homologue of CD1: Evidence for evolutionary conservation of the CD1D class and widespread transcription by rat cells
36. Sheep CD1 genes and proteins
37. Molecular cloning and characterization of a novel CD1 gene from the pig
38. Conservation of a CD1 multigene family in the guinea pig
39. Isolation of CD1 genes, a family of major histocompatibility complex-related differentiation antigens
40. Structure and expression of the human thymocyte antigens CD1a, CD1b and CD1c
41. Structural organization of rat CD1 typifies evolutionarily conserved CD1D class genes
42. Tissue-specific recognition of mouse CD1 molecules
43. CD1.1 expression by mouse antigen-presenting cells and marginal zone B cells
44. 2-microglobulin-dependent and independent forms
45. Tissue distribution of the non-polymorphic major histocompatibility complex class I-like molecule, CD1d
46. CD1d structure and regulation on human thymocytes, peripheral blood T cells, B cells and monocytes
47. Expression of murine CD1 on gastrointestinal epithelium
48. Tissue distribution, regulation and intracellular localization of murine CD1 molecules
49. IFN-γ modulates CD1d surface expression on intestinal epithelia
50. The CD1 family: A third lineage of antigen presenting molecules
51. Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove
52. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens
53. Structure of the human class I histocompatibility antigen, HLA-A2
54. Specificity pockets for the side chains of peptide antigens in HLA-Aw68
55. b molecule
56. Allele-specific motifs revealed by sequencing of self peptides eluted from MHC molecules
57. Structural requirements for antigen presentation by mouse CD1
58. The three-dimensional structure of peptide-MHC complexes
59. CD1b restricts the response of human CD4-D8-T lymphocytes to a microbial antigen
60. CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection
61. + T cells
62. CD1 restricted T cell recognition of microbial lipoglycan antigen
63. Structural requirements for glycolipid recognition by CD1b-restricted T cells
64. Self glycolipids as T-cell autoantigens
65. Peptide binding and presentation by mouse CD1
66. KRN7000, a novel immunomodulator, and its antitumor activities
67. Requirement for Vα14 NKT cells in IL-12-mediated rejection of tumors
68. The natural killer T (NKT) cell ligand αgalactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells
69. CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides
70. Selective ability of mouse CD1 to present glycolipids: α-galactosylceramide specifically stimulates Vα14+ NK T lymphocytes
71. CD1d-mediated recognition of an αgalactosylceramide by natural killer T cells is highly conserved through mammalian evolution
72. CD1d-restricted recognition of synthetic glycolipid antigens by human natural killer T cells
73. Activation of human Vα24NKT cells by α-glycosylceramide in a CD1d-restricted and Vα24TCR-mediated manner
74. Murine CD1d-restricted T cell recognition of cellular lipids
75. Methods to study peptides associated with MHC class I molecules
76. Allele-specific peptide ligand motifs of HLA-C molecules
77. Characterization of peptides bound to the class I MHC molecules HLA-A2.1 by mass spectrometry
78. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles
79. A non-polymorphic MHC class Ib molecule binds a large array of diverse self peptides
80. Natural ligand of mouse CD1d1: Cellular glycosylphosphatidylinositol
81. Structural requirements for galactosylceramide recognition by CD1-restricted NK T cells
82. Binding and antigen presentation of ceramide-containing glycolipids by soluble mouse and human CD1d molecules
83. Molecular interactions of CD1b with lipoglycan antigens
84. pH affects both the mechanism and the specificity of peptide binding to a class-II major histocompatibility complex molecule
85. 2-microglobulin
86. + T cells produce large amounts of IL-4 and IFN-γ upon activation by anti-CD3 or CD1
87. - T cells
88. The IgG response to the circumsporozoite protein is MHC class II-dependent and CD1d-independent: Exploring the role of GPIs in NK T cell activation and antimalarial responses
89. 2-microglobulin dependent surface expression of functional mouse CD1.1
90. The nature of the MHC class I peptide loading complex
91. Assembly, transport, and function of MHC class II molecules
92. +) T cells that express αβ T cell receptors in transporters associated with antigen presentation-null and thymus leukemia antigen positive mice
93. Targeting membrane proteins to endosomes and lysosomes
94. Mouse CD1-autoreactive T cells have diverse patterns of reactivity to CD1+ targets
95. PIG-B, a membrane protein of the endoplasmic reticulum with a large luminal domain, is involved in transferring the third mannose of the GPI anchor
96. A novel class of cell surface glycolipids of mammalian cells: Free glycosyl phosphatidylinositols
97. Distribution, metabolism and function of dolichol and polyprenols
98. Assembly of asparagine linked oligosaccharides
99. Topology of sphingolipid galactosyltransferases in ER and Golgi: Transbilayer movement of monohexosyl sphingolipids is required for higher glycosylsphingolipid biosynthesis
100. UDP-galactose: Ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum
101. Oligomerization and topology of the Golgi membrane protein glucosylceramide synthase
102. Assembly and retention of CD1b heavy chains in the endoplasmic reticulum
103. Participation of a novel 88 kD protein in the biogenesis of the murine class I histocompatibility molecules
104. MHC class I molecules form ternary complexes with calnexin and TAP and undergo peptide regulated interaction with TAP via their extracellular domains
105. Calnexin retains unassembled major histocompatibility complex class I free heavy chains in the endoplasmic reticulum
106. hi, TCR-Vβ8+ subset
107. + cells
108. + T cells
109. - cells
110. + T cell development in the CD3ζ-deficient mice
111. + γδ T cells are induced in mice by Salmonella infection
112. Lineage relationships and differentiation of natural killer (NK) T cells: Intrathymic selection and interleukin (IL)-4 production in the absence of NKR-P1 and Ly49 molecules
113. -TCR-αβ thymocytes
114. NKT cells are phenotypically and functionally diverse
115. + T cell subset from class II deficient mice
116. Functional characterization of NK1.1+ Ly-6C+ cells
117. Murine thymic CD4+ T cell subsets: A subset (Try0) that secretes diverse cytokines and overexpresses the Vβ8 T cell receptor gene family
118. Distinct roles for signals relayed through the common cytokine receptor y chain and interleukin 7 receptor a chain in natural T cell development
119. Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells
120. LFA-1 is required for liver NKI.I+TCR aft+ cell development: Evidence that liver NK1.1+TCR αβ+ cells originate from multiple pathways
121. A novel population of T cell receptor aft bearing thymocytes which predominantly express a single Vβ8 gene family
122. + thymocytes
123. + thymocytes: Variable influence of self antigens on T cell receptor Vβ usage
124. - single positive thymocyte subpopulation that expresses a highly skewed T cell antigen receptor family
125. Ontogeny of the immune system: γδ and aft T cells migrate from thymus to the periphery in alternating waves
126. + natural killer-T cell development
127. + T cells in the liver arise in the thymus and are selected by interactions with class I molecules on CD4+CD8+ cells
128. Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells
129. + aft T cells in IL-12 production daring Salmonella infection
130. Early appearance oft cell receptor αβ+ CD4- CD8- T cells with a skewed variable region repertoire after infection with Listeria monocytogenes
131. + T cell antigen receptor a chain expanded in unprimed mice
132. Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8-αβ T cells demonstrates preferential use of several Vβ genes and an invariant TCR α chain
133. An invariant T cell receptor a chain is used by a unique subset of MHC class I specific CD4+ and CD48- T cells in mice and humans
134. An invariant Vα24JαQ/Vβ11 T cell receptor is expressed in all individuals by clonally expanded CD4-D8-T cells
135. Human T cells expressing an invariant Vα24-JaQ TCR a are CD4 and heterogeneous with respect to TCR β expression
136. A novel recognition motif of human NKT antigen receptor for a glycolipid ligand
137. Organization, structure, and function of 95 kb of DNA spanning the murine T-cell receptor Cα/Cδ region
138. - thymocytes by class I molecules expressed by hematopoietic cells
139. + cells responsible for acute marrow graft rejection are present in thymus-deficient mice
140. + αβ T cells with intermediate TCR induced in liver of mice by IL-12
141. Evidence for extrathymic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation
142. Thymus independent T cell development and selection in the intestinal epithelium
143. + NK T cells in the early stages of embryogenesis
144. Thymus-independent generation of NK1+ T cells in vitro from fetal liver precursors
145. In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers
146. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers
147. Phenotypic analysis of antigen-specific T lymphocytes
148. Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
149. Coordinate regulation of complex T cell populations responding to bacterial infection
150. + NKT cells in germ-free mice
151. Development of functionally responsive T cells
152. Development and selection of T cells: Facts and puzzles
153. Early T lymphocyte progenitors
154. Transcriptional regulation oft lymphocyte development and function
155. Selection of the T cell repertoire
156. Role of common cytokine receptor γ chain in cytokine signaling and lymphoid development
157. Utilization of the β and γ chains of the IL-2 receptor by a novel cytokine IL-15
158. + cell development
159. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
160. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
161. -/- mice
162. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice
163. + T cells from IL-7-deficient mice have normal distribution and selection but exhibit impaired cytokine production
164. Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin
165. Absolute requirement for the pre-T cell receptor a chain during NK1.1+ TCR αβ cell development
166. NKT cell development is selectively impaired in Fyn-deficient mice
167. The src family tyrosine kinase Fyn regulates natural killer T cell development
168. Selectively impaired development of intestinal T cell receptor γδ+ cells and liver CD4+ NK1+ T cell receptor αβ+ cells in T cell factor-1-deficient mice
169. Positive and negative selection invoke distinct signaling pathways
170. Superantigens: Bacterial and viral proteins that manipulate the immune system
171. Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage
172. Lack of directed Vα14-Jα281 rearrangements in NK1 + T cells
173. + αβ T cells
174. Activation events during thymic selection
175. + CD4-8-T cells produce IL-4
176. + CD8- thymocytes with specific lymphokine secretion
177. Multiple differences in gene expression in regulatory Vα24JαQ T cells from identical twins discordant for type I diabetes
178. Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4
179. Role of NK1.1+ T cells in a Th2 response and in immunoglobulin E production
180. Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells
181. Rapid death and regeneration of NKT cells in anti-CD3ε- or IL- 12-treated mice: A major role for bone marrow in NKT cell homeostasis
182. A defect in IL-12-induced activation and IFNy secretion of peripheral natural killer T cells in nonobese diabetic mice suggests new pathogenic mechanisms for insulin-dependent diabetes mellitus (IDDM)
183. + TCR α/β intermediate liver lymphocytes are down-regulated by Listeria monocytogenes
184. Transient control of interleukin-4-producing natural killer T cells in the livers of Listeria monocytogenes-infected mice by interleukin-12
185. +NK1+ T lymphocytes
186. 2-microglobulin-deficient mice are protected from hypergammaglobulinemia and have defective responses because of increased IgG catabolism
187. 2-microglobulin independent and develop normally in the absence of IL-4 priming of T cells
188. + T cells are not essential for T helper cell 2 immune responses
189. 1.1- T cell population
190. In susceptible mice, Leishmania major induce very rapid interleukin-4 production by CD4+ T cells which are NK1.1
191. + natural killer T cells by Mycobacterium bovis bacillus Calmette Guerin
192. Emergence of NK1.1+ cells as effectors of IFN-γ dependent immunity to Toxoplasma gondii in MHC class I-deficient mice
193. A role for CD4+ NK1.1+ T lymphocytes as major histocompatibility complex class II independent helper cells in the generation of CD8+ effector function against intracellular infection
194. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis
195. Immunity to intracellular bacteria
196. Susceptibility of mice deficient in CD 1D or TAP 1 to infection with Mycobacterium tuberculosis
197. Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice
198. Murine natural killer T (NKT) cells contribute to the granulomatous reaction caused by mycobacterial cell walls
199. Perspectives on malaria vaccine development
200. + TCRαβ intermediate cells increase during experimental malaria infection and are able to exhibit inhibitory activity against parasite liver stage in vitro
201. α-galactosylceramide-activated Vα14 natural killer T cells mediate protection against murine malaria
202. CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells
203. Inhibition of experimental tumor metastasis by dendritic cells pulsed with α-galactosylceramide
204. Differential tumor surveillance by natural killer (NK) and NKT cells
205. Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12
206. Critical role of NK1+ T cells in IL-12-induced immune responses in vivo
207. Natural T cells: Cranking-up the immune system with prompt cytokine secretion
208. Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14 NKT cells
209. Antitumor cytotoxicity mediated by ligand-activated human Vα24 NKT cells
210. Human invariant Vα24+ natural killer T cells activated by α-galactosylceramide (KRN7000) have cytotoxic anti-tumour activity through mechanisms distinct from T cells and natural killer cells
211. Dendritic cells are targets for human invariant Vα24+ natural killer T-cell cytotoxic activity: An important immune regulatory function
212. Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells
213. The interface between innate and acquired immunity: Glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes
214. Augmentation of Vα14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis
215. Critical contribution of liver natural killer T cells to a murine model of hepatitis
216. The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of the natural killer type 1 positive cells: Evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion and autoimmune symptoms
217. Selective reduction oft cells bearing invariant Vα24JαQ antigen receptor in patients with systemic sclerosis
218. + NKT cells associated with disease development in autoimmune prone mice
219. Early quantitative and functional deficiency of NK1+-like thymocytes in the NOD mice
220. Flow cytometric study oft cell development in NOD mice reveals a deficiency in αβTCR+CDR-CD8- thymocytes
221. - T-cell deficiency and IDDM in NOD/Lt mice
222. - (NKT) thymocytes prevent insulin-dependent diabetes mellitus in non-obese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10
223. Extreme Th1 bias of invariant Va24JaQ T cells in type 1 diabetes
224. Differential expression of NK T cell Vα24JaαQ invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy
225. The nonobese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD
226. Overexpression of natural killer T cells protects Vα14Jα281 transgenic nonobese diabetic mice against diabetes
227. Interleukin-4 reverses T cell unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice
228. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
229. Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation
230. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
231. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
232. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
233. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
234. Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development
235. +NKT cells: Stimulation of IL-12 production by antigen-presenting cells in the innate immune system
236. Myeloid growth factors
237. Tumor necrosis factor, interleukin-6, macrophage migration inhibitory factor, and macrophage inflammatory protein-1 in inflammation
238. α-galactosylceramide induces early Bcell activation through IL-4 production by NKT cells
239. b class I molecule
240. CD1, tuberculosis, and the evolution of major histocompatibility complex molecules
241. Intracellular signalling from the endoplasmic reticulum to the nucleus
242. The unfolded protein response coordinates the production of ER protein and ER membrane
243. Phospholipid biosynthesis in yeast
244. Regulation of organelle biogenesis
245. The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes
246. Metabolism Of fatty acids and triacylglycerols
247. A novel pathway for glycan assembly: Biosynthesis of the glycosylphosphatidylinositol anchor of the trypanosome variant surface glycoprotein
248. Assembly and deacetylation of N-acetylglucosaminyl-plasmanylinositol in normal and affected paroxysmal nocturnal hemoglobinuria
249. The molecular basis for paroxysonocturnal hemoglobulinuria
250. Phosphatidylethanolamine is the donor of the ethanolamine residue linking a glycosylphosphatidylinositol anchor to protein
251. The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis
252. Identification of defects in glycosylphosphatidylinositol anchor biosynthesis in the Thy-1 expression mutants
253. Characterization of a glycophospholipid intermediate in the biosynthesis of glycosylphosphatidylinositol anchors accumulating in the Thy-1-negative lymphoma line S1A-b
254. The primary glycosylation defect in class E Thy-1 mutant negative mouse lymphoma cells is an inability to synthesize dolichol-P-mannose
255. Cloning of a human gene, PIG-F, a component of glycosylphosphatidylinositol anchor biosynthesis, by a novel expression cloning strategy
256. Myelin glycolipids and their function
257. Glucosylceramide synthase and glycosphingolipid synthesis