Critical role of interleukin 5 and eosinophils in concanavalin A-induced hepatitis in mice

Gastroenterology

Volumn 122, Issue 7, 2002, Pages 2001-2010

  Louis, Hubert ^a   Le Moine, Alain ^a   Flamand, Véronique ^a   Nagy, Nathalie ^b   Quertinmont, Eric ^a   Paulart, Frédéric ^a   Abramowicz, Daniel ^a   Le Moine, Olivier ^a   Goldman, Michel ^a   Devière, Jacques ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b ERASME HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAVALIN A; INTERLEUKIN 5;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL INFILTRATION; CELL MATURATION; CELL TRANSFER; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHIL; EXPERIMENTAL MODEL; HEPATITIS; LIVER INJURY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0036088872     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2002.33620     Document Type: Article

References (50)

1. Molecular pathogenesis of liver disease: An approach to hepatic inflammation, cirrhosis and liver transplant tolerance
2. Cytokines in alcoholic and nonalcoholic steato-hepatitis
3. Eosinophilic infiltration of the liver in primary biliary cirrhosis: A morphological study
4. The eosinophil as an effector cell of the immune response during hepatic allograft rejection
5. A T cell-dependent experimental liver injury in mice inducible by concanavalin A
6. T cell activation-associated hepatic injury: Mediation by tumor necrosis factors and protection by interleukin 6
7. Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice
8. Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A
9. Importance of Kupffer cells for T-cell-dependent liver injury in mice
10. Augmentation of Vα14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis
11. Mouse CD1-specific NK1 T cells: Development, specificity, and function
12. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells
13. A subset of CD4+ thymocytes selected by MHC class I molecules
14. Cultured NK1.1+ CD4+ T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1
15. Selective ability of mouse CD1 to present glycolipids: Alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes
16. IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses
17. The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent
18. Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmuno-adsorbent assay
19. Depletion of eosinophils in mice through the use of antibodies specific for C-C chemokine receptor 3 (CCR3)
20. Cytokine quantification by real-time PCR
21. Th2-induced eotaxin expression and eosinophilia coexist with Th1 responses at the effector stage of lung inflammation
22. Liver-associated lymphocytes expressing NK1.1 are essential for oral immune tolerance induction in a murine model
23. Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: Role for IFN-gamma in activating apoptosis of hepatocytes
24. Concanavalin A induces perforin-mediated but not Fas-mediated hepatic injury
25. Contribution of Fas ligand to T cell-mediated hepatic injury in mice
26. Critical contribution of liver natural killer T cells to a murine model of hepatitis
27. CD4+ and CD8+ T cells acquire specific lymphokine secretion potentials during thymic maturation
28. Murine thymic CD4+ T cell subsets: A subset (ThyO) that secretes diverse cytokines and overexpresses the V beta 8 T cell receptor gene family
29. Activation events during thymic selection
30. NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway
31. Eosinophil trafficking to sites of allergic inflammation
32. Eotaxin: From an eosinophilic chemokine to a major regulator of allergic reactions
33. Gastrointestinal eosinophils
34. Eosinophils generate brominating oxidants in allergen-induced asthma
35. Expression of CD28 and CD86 by human eosinophils and role in the secretion of type 1 cytokines (interleukin 2 and interferon gamma): Inhibition by immunoglobulin a complexes
36. Intracellular localization and release of eotaxin from normal eosinophils
37. Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis
38. A pivotal role of IL-12 in Th1-dependent mouse liver injury
39. Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon
40. Eosinophil-induced liver injury: An experimental model using IL-5 transgenic mice
41. Ursodeoxycholic acid inhibits eosinophil degranulation in patients with primary biliary cirrhosis
42. Elevations in IFN-gamma, IL-5, and IL-10 in patients with the autoimmune disease primary biliary cirrhosis: Association with autoantibodies and soluble CD30
43. Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis
44. Evidence for a nonclassical pathway of graft rejection involving interleukin 5 and eosinophils
45. Blood and graft eosinophilia as predictors of rejection in human liver transplantation
46. Acute eosinophilic hepatitis from trovafloxacin
47. Marked eosinophilia in a patient with primary sclerosing cholangitis
48. Tissue eosinophilia and eosinophil degranulation in syndromes associated with fibrosis
49. Histological changes of the liver in experimental graft-versus-host disease across minor histocompatibility barriers. VIII. Role of eosinophil infiltration
50. Eosinophil-induced chronic active hepatitis in the idiopathic hypereosinophilic syndrome