Immune suppression and skin cancer development: Regulation by NKT cells

Nature Immunology

Volumn 1, Issue 6, 2000, Pages 521-525

  Moodycliffe, Angus M ^a,c   Nghiem, Dat ^a,b   Clydesdale, Gavin ^a   Ullrich, Stephen E ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD1 ANTIGEN;

ANIMAL; ARTICLE; C3H MOUSE; C57BL MOUSE; DELAYED HYPERSENSITIVITY; FEMALE; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METABOLISM; MOUSE; MOUSE MUTANT; NATURAL KILLER CELL; RADIATION INJURY; SKIN TUMOR; SPLEEN; T LYMPHOCYTE SUBPOPULATION; ULTRAVIOLET RADIATION;

ANIMALS; ANTIGENS; ANTIGENS, CD1; FEMALE; HYPERSENSITIVITY, DELAYED; IMMUNE TOLERANCE; KILLER CELLS, NATURAL; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASMS, RADIATION-INDUCED; SKIN NEOPLASMS; SPLEEN; T-LYMPHOCYTE SUBSETS; ULTRAVIOLET RAYS;

EID: 0034569294     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/82782     Document Type: Article

References (27)

1. Boring, C. C., Squires, T. S. & Tong, T. Cancer Statistics. Cancer J. Clin. 41, 19-38 (1992).
2. Urbach, F. Ultraviolet radiation and skin cancer of humans. J. Photochem. Photobiol. B 40, 3-7 (1997).
3. Penn, I. Depressed immunity and skin cancer. Immunol. Today 5, 291-293 (1984).
4. Yoshikawa, T. et al. Susceptibility to effects of UVB radiation on induction of contact hypersensitivity as a risk factor for skin cancer in humans. J. Invest. Dermatol. 95, 530-536 (1990).
5. Fisher, M. S. & Kripke, M. L. Suppressor T lymphocytes control the development of primary skin cancers in UV-irradiated mice. Science 216, 1133-1134 (1982).
6. Ullrich, S. E. & Kripke, M. L. Mechanisms in the suppression of tumor rejection produced in mice by repeated UV irradiation. J. Immunol. 133, 2786-2790 (1984).
7. Daynes, R. A. & Spellman, C. W. Evidence for the generation of suppressor cells by UV radiation. Cell. Immunol. 31, 182-187 (1977).
8. Fisher, M. S. & Kripke, M. L. Systemic alteration induced in mice by ultraviolet light irradiation and its relationship to ultraviolet carcinogenesis. Proc. Natl Acad. Sci. USA. 74, 1688-1692 (1977).
9. Rivas, J. M. & Ullrich, S. E. The role of IL-4, IL-10, and TNF-α in the immune suppression induced by ultraviolet radiation. J. Leukoc. Biol. 56, 769-775 (1994).
10. Vicari, A. P. & Zlotnik, A. Mouse NK1.1+ T cells: a new family of T cells. Immunol. Today 17, 71-76 (1996).
11. Bendelac, A., Rivera, M. N., Park, S. H. & Roark, J. H. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu. Rev. Immunol. 15, 535-562 (1997).
12. + T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179, 1285-1295 (1994).
13. + T cells exist in naive NK1.1 allelic positive and negative mice, with the capacity to rapidly secrete large amounts of IL-4 and IFN-γ upon primary TCR stimulation. J. Immunol. 162, 5156-5163 (1999).
14. Mendiratta, S. K. et al. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6, 469-477 (1997).
15. + T lymphocytes. Science 268, 863-865 (1995).
16. Zeng, D. F. et al. Bone marrow NK1.1(-) and NK1.1(+) T cells reciprocally regulate acute graft versus host disease. J. Exp. Med. 189, 1073-1081 (1999).
17. Sonoda, K.-H., Exley, M., Snapper, S., Balk, S. P. & Stein-Streilein, J. CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J. Exp. Med. 190, 1215-1226 (1999).
18. α14 natural killer T cells are essential for acceptance of rat islet xenografts in mice. J. Clin. Invest. 105, 1761-1767 (2000).
19. -/- mice. J Immunol 157, 2366-2373 (1996).
20. Singh, N. et al. Cutting Edge: Activation of NK T cells by CD1d and α-Galactosyl-ceramide directs conventional T cells to the acquisition of a Th2 phenotype. J. Immunol. 163, 2373-2377 (1999).
21. Zeng, Z. -H. et al. Crystal structure of mouse CD1: an MHC-like fold with a large hydrophobic binding groove. Science 227, 339-345 (1997).
22. Moody, D. B., Besra, G. S., Wilson, I.A. & Porcelli, S.A. The molecular basis of CD1-mediated presentation of lipid antigens. Immunol. Rev, 172, 285-296 (1999).
23. Castano, A. R. et al. Peptide binding and presentation by mouse CD1. Science 269, 223-226 (1995).
24. Lee, D. J., Abeyratne, A., Carson, D. A. & Corr, M. Induction of an antigen-specific, CD1-restricted cytotoxic T lymphocyte response in vivo. J. Exp. Med. 187, 433-438 (1998).
25. + T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo. J. Immunol. 165, 3673-3679 (2000).
26. Ullrich, S. E. & Magee, M. J. Specific suppression of allograft rejection after treatment of recipient mice with UV radiation and allogeneic spleen cells. Transplantation 46, 115-119 (1988).
27. Ullrich, S. E., McIntyre, B.W. & Rivas, J. M. Suppression of the immune response to alloantigen by factors released from ultraviolet-irradiated keratinocytes. J. Immunol. 145, 489-498 (1990).