During Trypanosoma cruzi infection CD1d-restricted NK T cells limit parasitemia and augment the antibody response to a glycophosphoinositol-modified surface protein

Infection and Immunity

Volumn 70, Issue 1, 2002, Pages 36-48

  Duthie, M S ^a   Wleklinski Lee, M ^a   Smith, S ^a   Nakayama, T ^a   Taniguchi, M ^a   Kahn, S J ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD1D ANTIGEN; GAMMA INTERFERON; GLYCOSYLPHOSPHATIDYLINOSITOL; INTERLEUKIN 12; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CHAGAS DISEASE; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; FEMALE; LIVER; LYMPHOCYTE DEPLETION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PARASITEMIA; PRIORITY JOURNAL; PROTEIN MODIFICATION; SPLEEN; T LYMPHOCYTE ACTIVATION; TRYPANOSOMA CRUZI;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, CD1; CELL DIVISION; CELLS, CULTURED; CHAGAS DISEASE; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; FEMALE; GALACTOSYLCERAMIDES; INTERFERON TYPE II; INTERLEUKIN-4; KILLER CELLS, NATURAL; LIVER; LYMPHOCYTE COUNT; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; PARASITEMIA; SPLEEN; T-LYMPHOCYTES; TRYPANOSOMA CRUZI; VARIANT SURFACE GLYCOPROTEINS, TRYPANOSOMA;

EID: 0036138267     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.1.36-48.2002     Document Type: Article

References (56)

1. Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes
2. Highly purified glycosylphosphatidylinositols from Trypanosoma cruzi are potent proinflammatory agents
3. IL-12 and IFN-gamma production, and NK cell activity, in acute and chronic experimental Trypanosoma cruzi infections
4. Murine natural killer cells contribute to the granulomatous reaction caused by mycobacterial cell walls
5. Development of resistance to Trypanosoma cruzi in mice depends on a viable population of L3T4+ (CD4+) T lymphocytes
6. NKT lymphocyte ontogeny and function are impaired in low antibody-producer Biozzi mice: Gene mapping in the interval-specific congenic strains raised for immunomodulatory genes
7. CD8+ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo
8. Persistence of Trypanosoma cruzi antigens in the inflammatory lesions of chronically infected mice
9. Natural killer cells in antiviral defense: Function and regulation by innate cytokines
10. Detection of parasite DNA in Chagas' heart disease
11. Immunization with alpha-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis
12. Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin 10: Role of NK cells
13. Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells
14. Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice
15. Ligation of intestinal epithelial CD1d induces bioactive IL-10: Critical role of the cytoplasmic tail in autocrine signaling
16. Requirement for Vα 14 NKT cells in IL-12-mediated rejection of tumors
17. A role for CD4+ NK1.1+ T lymphocytes as major histocompatibility complex class II independent helper cells in the generation of CD8+ effector function against intracellular infection
18. Rapid death and regeneration of NKT cells in anti-CD3ε- or IL-12-treated mice: A major role for bone marrow in NKT cell homeostasis
19. Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells
20. NKT cells: Facts, functions and fallacies
21. α-Galactosylceramide-activated Vα 14 natural killer T cells mediate protection against murine malaria
22. Isolation and flow cytometric analysis of the free lymphomyeloid cells present in murine liver
23. Increased natural killer cell activity in experimental American trypanosomiasis
24. A method for counting and concentrating living Trypanosoma cruzi in blood lysed with ammonium chloride
25. Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase
26. Immune privilege: Keeping an eye on natural killer T cells
27. IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi
28. Interleukin-12-mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor alpha and gamma interferon
29. CD4(+) Vα14 NKT cells play a crucial role in an early stage of protective immunity against infection with Leishmania major
30. Enhanced resistance to acute infection with Trypanosoma cruzi in mice treated with an interferon inducer
31. Natural ligand of mouse CD1d1: Cellular glycosylphosphatidylinositol
32. The major 85-kDa surface antigen of the mammalian-stage forms of Trypanosoma cruzi is a family of sialidases
33. Trypanosoma cruzi: Monoclonal antibodies to the surface glycoprotein superfamily differentiate subsets of the 85-kDa surface glycoproteins and confirm simultaneous expression of variant 85-kDa surface glycoproteins
34. + natural killer T cells by α-galactosylceramide results in development of Th1 response and local host resistance in mice infected with Cryptococcus neoformans
35. CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides
36. Influence of acute-phase parasite load on pathology, parasitism, and activation of the immune system at the late chronic phase of Chagas' disease
37. Tracking the response of natural killer cells to a glycolipid antigen using CD1d tetramers
38. Endogenous interferon-gamma, macrophage activation, and murine host defense against acute infection with Trypanosoma cruzi
39. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4
40. Cutting edge: Contribution of NK cells to the homing of thymic CD4+NKT cells to the liver
41. Cutting edge: The IgG response to the circumsporozoite protein is MHC class II-dependent and CD1d-independent: Exploring the role of GPIs in NK T cell activation and antimalarial responses
42. Liver CD4- CD8- NK1.1 + TCR alpha beta intermediate cells increase during experimental malaria infection and are able to exhibit inhibitory activity against the parasite liver stage in vitro
43. Antigenic polymorphism of Trypanosoma cruzi: Clonal analysis of trypomastigote surface antigens
44. Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei
45. Control of Trypanosoma cruzi infection in mice deprived of T-cell help
46. CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells
47. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells
48. Selective reduction of T cells bearing invariant V alpha 24J alpha Q antigen receptor in patients with systemic sclerosis
49. Susceptibility of beta 2-microglobulin-deficient mice to Trypanosoma cruzi infection
50. "Autoimmune rejection" of neonatal heart transplants in experimental Chagas disease is a parasite-specific response to infected host tissue
51. Endogenous IFN-gamma is required for resistance to acute Trypanosoma cruzi infection in mice
52. Enhancement of natural killer (NK) cell cytotoxicity and induction of NK cell-derived interferon-gamma (IFN-gamma) display different kinetics during experimental infection with Trypanosoma cruzi
53. Details of an isolation method for hepatic lymphocytes in mice
54. Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes
55. Genetic control of responses to Trypanosoma cruzi in mice: Multiple genes influencing parasitemia and survival