Activation of hepatic NKT cells and subsequent liver injury following administration of α-galactosylceramide

European Journal of Immunology

Volumn 30, Issue 7, 2000, Pages 1919-1928

  Osman, Yasser ^a   Kawamura, Toshihiko ^a   Naito, Tetsuya ^a   Takeda, Kazuyoshi ^b   Van Kaer, Luc ^c   Okumura, Ko ^b   Abo, Toru ^a  

^a NIIGATA UNIVERSITY   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

galactosylceramide; Apoptosis; CD1d; Hepatic injury; NKT cell

Indexed keywords

AMINOTRANSFERASE; GALACTOSYLCERAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; IMMUNOMODULATION; LIVER; LIVER INJURY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN;

AGING; ANIMALS; ANTIGENS; ANTIGENS, CD1; ANTIGENS, SURFACE; APOPTOSIS; BETA 2-MICROGLOBULIN; CELL COUNT; CYTOTOXICITY, IMMUNOLOGIC; GALACTOSYLCERAMIDES; IMMUNOPHENOTYPING; INJECTIONS, INTRAPERITONEAL; KILLER CELLS, NATURAL; KINETICS; LECTINS, C-TYPE; LIVER; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; PROTEINS; SPLEEN; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0033939943     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200007)30:7<1919::AID-IMMU1919>3.0.CO;2-3     Document Type: Article

References (55)

1. Kawano, T., Junqing, C., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K., Ueno, H., Nakagawa, R., Sato, H., Kondo, E., Koseki, H. and Taniguchi, M., CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides Science 1997. 278: 1626-1629.
2. + NK T lymphocytes. J. Immunol. 1998. 161: 3271–3281.
3. Brossary, L., Naidenko, O., Burdin, N., Matsuda, J., Sakai, T. and Kronenberg, M., Structural requirements for galactosylceramide recognition by CD1-restricted NKT cells. J. Immunol. 1998. 161: 5124-5128.
4. Burdin, N., Brossay, L. and Kronenberg, M., Immunization with α-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis. Eur. J. Immunol. 1999. 29: 2014-2025.
5. Brossary, L., Chioda, M., Burdin, N., Koezuka, Y., Casorati, G., Delalbona, P. and Kronenberg, M., CD1d-mediated recognition of an α-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution. J. Exp. Med. 1998. 188: 1521-1528.
6. Spada, F. M., Koezuka, Y. and Porcelli, S. A., CD1d-restricted recognition of synthetic glycolipid antigens by human natural killer T cells. J. Exp. Med. 1998. 188: 1529-1534.
7. Kawano, T., Tanaka, Y., Shimizu, E., Kaneko, Y., Kamata, N. H., Sato, H., Osada, N., Sekiya, S., Nakayama, T. and Taniguchi, M., A novel recognition motif of human NKT antigen receptor for a glycolipid ligand. Int. Immunol. 1999. 11: 881-887.
8. + T cells. Curr. Opin. Immunol. 1995. 7: 367-374.
9. + cells: new clues to their origin, specificity, and function. J. Exp. Med. 1995. 182: 633-638.
10. + T cells: a new family of T cells. Immunol. Today 1996. 17: 71-76.
11. +T cells are present within a population of intermediate TCR cells. J. Immunol. 1995. 155: 2972-2983.
12. Abo, T., Watanabe, H., Sato, K., liai, T., Moroda, T., Takeda, K. and Seki, S., Extrathymic T cells stand at an intermediate phylogenetic position between natural killer cells and thymus-derived T cells. Nat. Immun. 1995. 14: 173-187.
13. + subsets, using Fas ligand/Fas molecules. Immunology 1997 91-219–226.
14. + T cells upon NKR-P1 cross-linking. J. Exp. Med. 1996. 183: 2391–2396.
15. + T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 1994. 179: 1285-1295.
16. Eberl, G., Lees, R., Smiley, S. T., Taniguchi, M., Grusby, J. J. and MacDonald, H. R., Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells. J. Immunol. 1999. 162: 6410-6419.
17. + cells expressing intermediate levels of the T cell receptor in the liver and other immune organs. Fur. J. Immunol. 1995. 25: 2272-2278.
18. Suzuki, S., Sugahara, S., Shimizu, T., Tada, T., Minagawa, M., Maruyama, S., Watanabe, H., Saito, H., Ishikawa, H., Hatakeyama, K. and Abo, T., Low level of mixing of partner cells seen in extrathymic T cells in the liver and intestine of parabiotic mice: Its biological implication. Eur. J. Immunol. 1999. 28: 3719-3729.
19. + thymocytes. J. Exp. Med. 1994. 180: 395-399.
20. Crispe, I. N. and Mehal, W. Z., Strange brew: T cells in the liver. Immunol. Today 1996. 17: 522-525.
21. Moroda, T., liai, T., Kawachi, Y., Kawamura, T., Hatakeyama, K. and Abo, T., Restricted appearance of self-reactive clones into intermediate T cell receptor cells in neonatally thymectomized mice with autoimmune disease. Eur. J. Immunol. 1996. 26: 3084-3091.
22. liai, T., Watanabe, H., Seki, S., Sugiura, K., Hirokawa, K., Utsuyama, M., Takahashi-Iwanaga, H., Iwanaga, T., Ohteki, T. and Abo, T., Ontogeny and development of extrathymic T cells in mouse liver. Immunology 1992. 77: 556-563.
23. Ohtsuka, K., liai, T., Watanabe, H., Tanaka, T., Miyasaka, M., Sato, K., Asakura, H. and Abo, T., Similarities and differences between extrathymic T cells residing in mouse liver and intestine. Cell. Immunol. 1994. 153: 52-66.
24. Tsukahara, A., Seki, S., liai, T., Moroda, T., Watanabe, H., Suzuki, S., Tada, T., Hiraide, H., Hatakeyama, K. and Abo, T., Mouse liver T cells: Their change with aging and in comparison with peripheral T cells. Hepatology 1997. 26: 301-309.
25. Kimura, M., Hanawa, H., Watanabe, H., Ogawa, M. and Abo, T., Synchronous expansion of intermediate TCR cells in the liver and uterus during pregnancy. Cell. Immunol. 1995. 162: 16-25.
26. Narita, J., Miyaji, C., Watanabe, H., Honda, S., Koya, T., Umezu, H., Ushiki, T., Sugahara, S., Kawamura, T., Arakawa, M. and Abo, T., Differentiation of forbidden T cell clones and granulocytes in the parenchymal space of the liver in mice treated with estrogen. Cell. Immunol. 1998. 185: 1-13.
27. + T cells as well as NK cells against intraperitoneal tumors in mice. Cell. Immunol. 1999. 193: 219-225.
28. Watanabe, T., Kawamura, T., Kawamura, H., Haga, M., Shirai, K., Watanabe, H., Eguchi, S. and Abo, T., Intermediate T-cell receptor cells in mouse lung. Their effector function to induce pneumonitis in mice with autoimmune-like graft-versus-host disease. J. Immunol. 1997. 158: 5805-5814.
29. Weerasinghe, A., Kawamura, T., Moroda, T., Seki, S., Watanabe, H. and Abo, T., Intermediate TCR cells can induce graft-versus-host disease after allogeneic bone marrow transplantation. Cell. Immunol. 1998. 185: 14-29.
30. Kimura, M., Watanabe, H., Ohtsuka, K., liai, T., Tsuchida, M., Sato, S. and Abo, T., Radioresistance of intermediate TCR cells and their localization in the body of mice revealed by irradiation. Microbiol. Immunol. 1993. 37: 641-652.
31. Halder, R. C., Seki, S., Weerasinghe, A., Kawamura, T., Watanabe, H. and Abo, T., Characterization of NK cells and extrathymic T cells generated in the liver of irradiated mice with a liver shield. Clin. Exp. Immunol. 1998. 144: 434-447.
32. Maruyama, S., Minagawa, M., Shimizu, T., Oya, H., Yamamoto, S., Musha, N., Abo, W., Weerasinghe, A., Hatakeyama, K. and Abo, T., Administration of glucocorticoids markedly increases the numbers of granulocytes and extrathymic T cells in the bone marrow. Cell. Immunol. 1999. 194: 28-35.
33. Kawamura, H., Kawamura, T., Kokei, Y., Mori, M., Matsuura, A., Oya, H., Honda, S., Suzuki, S., Weerasinghe, A., Watanabe, H. and Abo, T., Expansion of extrathymic T cells as well as granulocytes in the liver and other organs of G-CSF transgenic mice: Why they lost the ability of hybrid resistance. J. Immunol. 1999. 162: 5957-5964.
34. + T cells are resistant to glucocorticoid-induced apoptosis: implications for the Th1/Th2 balance. J. Immunol. 1998. 161: 1239-1247.
35. Sacco, S., Heremans, H., Echtenacher, B., Buurman, W. A., Amraoui, Z., Goldman, M. and Ghezzi, P., Protective effect of a single interleukin-12 (IL-12) predose against the toxicity of subsequent chronic IL-12 in mice: role of cytokines and glucocorticoids. Blood 1997. 90: 4473-4479.
36. + T cells in IL-12-induced immune responses in vivo. J. Immunol. 1998. 160: 16-19.
37. Kitching, A. R., Tipping, P. G. and Holdsworth, S. R., IL-12 directs severe renal injury, crescent formation and Th1 responses in murine glomerulonephritis. Eur. J. Immunol. 1999. 29: 1-10.
38. Eberl, G. and MacDonald, H. R., Rapid death and regeneration of NKT cells in anti-CD3ε-or IL-12-treated mice: A major role for bone marrow in NKT cell homeostasis. Immunity 1998. 9: 345-353.
39. Burdin, N., Brossay, L. and Kronenberg, M., Immunization with α-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis. Eur. J. Immunol. 1999. 29: 2014-2025.
40. Cui, J., Watanabe, N., Kawano, T. Yamashita, M., Kamata, T., Shimizu, C., Kimura, M., Shimizu, E., Koike, J., Koseki, H., Tanaka, Y., Taniguchi, M. and Nakayama, T., Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Vα14 natural killer T cells. J. Exp. Med. 1999. 190: 783-792.
41. Chiu, Y.-H., Jayawardena, J., Weiss, A., Lee, D., Park, S.-H., Dautry-Varsat, A. and Bendelac, A., Distinct subsets of CD1d-restricted T cells recognize self-antigen loaded in different cellular compartments. J. Exp. Med. 1999. 189: 103-110.
42. Kitamura, H., Iwakabe, K., Yahata, T., Nishimura, S., Ohta, A., Ohmi, Y., Sato, M., Takeda, K., Okumura, K., Van Kaer, L., Kawano, T., Taniguchi, M. and Nishimura, T., The natural killer T (NKT) cell ligand α-Galactosylceramide demonstrated its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J. Exp. Med. 1999. 189: 1121-1127.
43. + TCRαβint liver lymphocytes: influence of thymus, β2-microglobulin and NK1.1 expression. Int. Immunol. 1995. 7: 1729-1739.
44. Itoh, H., Abo, T., Sugawara, S., Kanno, A. and Kumagai, K., Age-related variation in the proportion and activity of murine liver natural killer cells and their cytotoxicity against regenerating hepatocytes. J. Immunol. 1988. 141: 315-323.
45. Segal, B. M. and Shevach, E. M. IL-12 unmasks latent autoimmune disease in resistant mice. J. Exp. Med. 1996. 184: 771-775.
46. Takeda K. and Dennert, G., The development of autoimmunity in C57BL/6 lpr mice correlated with the disappearance of natural killer type 1-positive cells: evidence of their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune symptoms. J. Exp. Med. 1993. 177: 155-164.
47. Wilson, S. B., Kent, S. C., Patton, K. T., Orban, T., Jackson, R. A., Exley, M., Porcelli, S., Schatz, D. A., Atkinson, M. A., Balk, S. P., Strominger, J. L. and Hafler, D. A., Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature 1998. 391: 177-181.
48. + thymocytes. J. Autoimmun. 1997. 10: 279-285.
49. + T-cell deficiency and IDDM in NOD/Lt mice. Diabetes 1997. 46: 572-582.
50. Lehuen, A., Lantz, O., Beaudoin, L., Laloux, V., Carnaus, C., Bendelac, A., Bach, J.-F. and Monteiro, R. C., Overexpression of natural killer T cells protects Vα14-Jα281 transgenic nonobese diabetic mice against diabetes. J. Exp. Med. 1998. 188: 1831-1839.
51. + αβ T cells with intermediate TCR induced in the liver of mice by IL-12. J. Immunol. 1995. 154: 4333-4340.
52. Cui, J., Shin , T., Kawano, T., Sato, H., Kondo, E., Toura, I., Kaneko, Y., Koseki, H., Knno, M. and Taniguchi, M., Requirement for Vα14 NKT cells in IL-12-mediated rejection of tumors. Science 1997. 278: 1623-1626.
53. + T cells. Science 1990. 248: 1227-1230.
54. Mendiratta, S. K., Martin, W. D., Hong, S., Boesteanu, A., Joyce, S. and Van Kaer, L., CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 1997. 6: 469-477.
55. Vermes, I., Haanen, C., Steffens-Nakken, H. and Reutelingsperger, C., A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods 1995. 184: 39-51.