Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase

Journal of Cell Science

Volumn 114, Issue 5, 2001, Pages 953-963

  Campbell, Michael S ^a   Chan, Gordon K T ^a   Yen, Tim J ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

Checkpoint; Kinetochore; MAD1; MAD2; Nuclear pore complex

Indexed keywords

CELL CYCLE PROTEIN; PROTEIN ANTIBODY; PROTEIN MAD1; PROTEIN MAD2; PROTEIN P55; TAX PROTEIN; VIRUS PROTEIN;

ANAPHASE; ANTIBODY LABELING; ARTICLE; CELL COMPOSITION; CELL CYCLE; CELL NUCLEUS MEMBRANE; CENTROMERE; CHROMOSOME ANALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTERPHASE; MAMMAL CELL; MEMBRANE CHANNEL; METAPHASE; MITOSIS; MITOSIS SPINDLE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; VIRUS CELL TRANSFORMATION; YEAST;

AMINO ACID SEQUENCE; ANTIBODIES; CALCIUM-BINDING PROTEINS; CELL CYCLE PROTEINS; CLONING, MOLECULAR; HELA CELLS; HUMANS; INTERPHASE; MOLECULAR SEQUENCE DATA; NUCLEAR PORE; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROTEIN BINDING; REPRESSOR PROTEINS;

HTLV; HUMAN T-LYMPHOTROPIC VIRUS 1; MAMMALIA; SACCHAROMYCETALES;

EID: 0035063690     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Alexandru, G., Zachariae, W., Schleifler, A. and Nasmyth, K. (1999). Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage. EMBO J. 18, 2707-2721.
2. Bodoor, K., Shaikh, S., Enarson, P., Chowdhury, S., Salina, D., Raharjo, W. H. and Burke, B. (1999). Function and assembly of nuclear pore complex proteins. Biochem. Cell. Biol. 77, 321-329.
3. Burton, M., Upadhyaya, C. D., Maier, B., Hope, T. S. and Semmes, O. J. (2000). Human T-cell leukemia virus type 1 tax shuttles between functionally discrete subcellular targets. J. Virol. 74, 2351-2364.
4. Chen, R. H., Waters, J. C., Salmon, E. D. and Murray, A. W. (1996). Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science 274, 242-246.
5. Chen, R. H., Shevehenko, A., Mann, M. and Murray, A. W. (1998). Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores. J. Cell Biol. 143, 283-295.
6. Chen, R. H., Brady, D. M., Smith, D., Murray, A. W. and Hardwick, K. G. (1999). The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins. Mol. Biol. Cell. 10, 2607-2618.
7. Davis, L. I. and Blobel, G. (1986). Identification and characterization of a nuclear pore complex protein. Cell 45, 699-709.
8. Fang, G., Yu, H. and Kirschner, M. W. (1999). Control of mitotic transitions by the anaphase-promoting complex. Philos. Trans. R. Soc. Land. B. Biol. Sci. 354, 1583-1590.
9. Fesquet, D., Fitzpatrick, P. J., Johnson, A. L., Kramer, K. M., Toyn, J. H. and Johnston, L. H. (1999). A Bub2p-dependent spindle checkpoint pathway regulates the Dbf2p kinase in budding yeast. EMBO J. 18, 2424-2434.
10. Fraschini, R., Formenti, E., Lucchini, G. and Piatti, S. (1999). Budding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2. J. Cell Biol. 145, 979-991.
11. Haaf, T. and Schmid, M. (1989). Centromeric association and non-random distribution of centromeres in human tumour cells. Hum. Genet. 81, 137-143.
12. Hardwick, K. G. and Murray, A. W. (1995). Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast. J. Cell Biol. 131, 709-720.
13. Hardwick, K. G., Weiss, E., Luca, F. C., Winey, M. and Murray, A. W. (1996). Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption. Science 273, 953-956.
14. Hershko, A. (1999). Mechanisms and regulation of the degradation of cyclin B. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 354, 1571-1575.
15. Howell, B. J., Hoffman, D. B., Fang, G., Murray, A. W., Salmon, E. D. (2000). Visualization of Mad2 dynamics at kinetochores, along spindlen fibers, and at spindle poles in living cells. J. Cell Biol. 150, 1233-1250.
16. Hoyt, M. A., Totis, L. and Roberts, B. T. (1991). S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 66, 507-517.
17. Hwang, L. H., Lau, L. F., Smith, D. L., Mistrot, C. A., Hardwick, K. G., Hwang, E. S., Amon, A. and Murray, A. W. (1998). Budding yeast Cdc20: a target of the spindle checkpoint. Science 279, 1041-1044.
18. Imreh, G. and Hallberg, E. (2000). An integral membrane protein from the nuclear pore complex is also present in the annulate lamellae: implications for annulate lamellae formation. Exp. Cell Res. 259, 180-190.
19. Jin, D. Y., Spencer, F. and Jeang, K. T. (1998). Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell 93, 81-91.
20. Kallio, M., Weinstein, J., Daum, J. R., Burke, D. J. and Gorbsky, G. J. (1998). Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. J. Cell Biol. 141, 1393-1406.
21. Kaufmann, S. H., Gibson, W. and Shaper, J. H. (1983). Characterization of the major polypeptides of the rat liver nuclear envelope. J. Biol. Chem. 258, 2710-2719.
22. Kessel, R. G. (1992). Annulate lamellae: a last frontier in cellular organelles. Int. Rev. Cytol. 133, 43-120.
23. Li, R. and Murray, A. W. (1991). Feedback control of mitosis in budding yeast. Cell 66, 519-531.
24. Li, X. and Nicklas, R. B. (1995). Mitotic forces control a cell-cycle checkpoint. Nature 373, 630-632.
25. Li, Y. and Benezra, R. (1996). Identification of a human mitotic checkpoint gene: hsMAD2. Science 274, 246-248.
26. Li, Y., Gorbea, C., Mahaffey, D., Rechsteiner, M. and Benezra, R. (1997). MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity. Proc. Nat. Acad. Sci. USA 94, 12431-12436.
27. Liu, Y. C., Pan, J., Zhang, C., Fan, W., Collinge, M., Bender, J. R. and Weissman, S. M. (1999). A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2. Proc. Nat. Acad. Sci. USA 96, 4313-4318.