Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

Nature Genetics

Volumn 17, Issue 4, 1997, Pages 423-431

  Connor, Frances ^a   Bertwistle, David ^a   Joseph Mee, P ^b   Ross, Gillian M ^c   Swift, Sally ^a   Grigorieva, Elena ^b   Tybulewicz, Victor L J ^b   Ashworth, Alan ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER GENETICS; DNA DETERMINATION; DNA REPAIR; FIBROBLAST CULTURE; GENE MUTATION; GENOTYPE; HOMOZYGOSITY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA;

EID: 0030659153     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1297-423     Document Type: Article

References (12)

1. Szabo, C.A. & King, M.-C. Inherited breast and ovarian cancer. Hum. Mol. Genet. 4, 1811-1817 (1995).
2. Stratton, M.R. & Wooster, R. Hereditary predisposition to breast cancer. Curr. Opin. Genet. Dev. 6, 93-97 (1996).
3. Easton, D. Breast cancer genes - what are the real risks? Nature Genet. 16, 210-211 (1997).
4. Hall, J. M. et al. Linkage of early-onset familial breast cancer to chromosome 17q21. Science 250, 1684-1689 (1990).
5. Miki, Y. et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66-71 (1994).
6. Wooster, R. et al. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science 265, 2088-2090 (1994).
7. Wooster, R. et al. Identification of the breast cancer susceptibility gene BRCA2. Nature 378, 789-792 (1995).
8. Futreal, P.A. et al. BRCA1 mutations in primary breast and ovarian carcinomas. Science 266, 120-122 (1994).
9. Lancaster, J.M. et al. BKCA2 mutations in primary breast and ovarian cancers. Nature Genet. 13, 238-240 (1996).
10. Miki, Y., Katagiri, T., Kasumi, F., Yoshimoto, T. & Nakamura, Y. Mutation analysis in the BRCA2 gene in primary breast cancers. Nature Genet. 13, 245-247 (1996).
11. Teng, D.H.-F. et al. Low incidence of BRCA2 mutations in breast carcinoma and other cancers. Nature Genet. 13, 241-244 (1996).
12. Tavtigian, S.V. et al. The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nature Genet. 12, 333-337 (1996).