Somatic mutations of PTEN in glioblastoma multiforme

Cancer Research

Volumn 57, Issue 19, 1997, Pages 4183-4186

  Wang, Steven I ^a   Puc, Janusz ^a   Li, Jing ^a   Bruce, Jeffrey N ^a   Cairns, Paul ^b   Sidransky, David ^b   Parsons, Ramon ^a,c  

^a The New York Presbyterian Hospital   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CARCINOGENESIS; CHROMOSOME 10Q; CLINICAL ARTICLE; DELETION MUTANT; EXON; GENE LOCATION; GENE REARRANGEMENT; GLIOBLASTOMA; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MOLECULAR CLONING; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ASTROCYTOMA; BRAIN NEOPLASMS; CHROMOSOMES, HUMAN, PAIR 10; CYCLINS; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; EXONS; GENES, P53; GENES, TUMOR SUPPRESSOR; GLIOBLASTOMA; HUMANS; LOSS OF HETEROZYGOSITY; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTOR, EPIDERMAL GROWTH FACTOR; SEQUENCE DELETION;

EID: 0030799909     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Neoplasms of the central nervous system. In: Louis, D. N., and Cavenee, W. K. In: V. T. DeVita, Jr., S. Hellman, and S. A. Rosenberg (eds.), Cancer: Principles and Practice of Oncology, Ed. 5, pp. 2013-2017. Philadelphia: Lippincott-Raven Publishers, 1997.
2. von Deimling, A., Louis, D. N., and Wiestler, O. D. Molecular pathways in the formation of gliomas. Glia, 15: 328-338, 1995.
3. Jen, J., Harper, J. W., Bigner, S. H., Bigner, D. D., Papadopoulos, N., Markowitz, S., Willson, J. K. V., Kinzler, K. W., and Vogelstein, B. Deletion of p16 and p15 genes in brain tumors. Cancer Res., 54: 6353-6358, 1994.
4. Schmidt, E. E., Ichimura, K., Reifenberger, G., and Collins. V. P. CDKN2 (p16/ MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. Cancer Res., 54: 6321-6324, 1994.
5. Ichimura, K., Schmidt, E. E., Goike, H. M., and Collins, V. P. Human glioblastomas with no alterations of the CDKN2A (p16, INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene. Oncogene. 13: 1065-1072, 1996.
6. Bögler, O., Huang, H. J. S., Kleihues, P., and Cavenee, W. K. The p53 gene and its role in human brain tumors. Glia, 15: 308-327, 1995.
7. Collins, V. P. Gene amplification in human gliomas. Glia, 15: 289-296, 1995.
8. Rasheed, B. K. A., McLendon, R. E., Herndon, J. E., Friedman, H. S., Friedman, A. H., Bigner, D. D., and Bigner, S. H. Alterations of the TP53 gene in human gliomas. Cancer Res., 54: 1324-1330, 1994.
9. Albarosa, R., Colombo, B. M., Roz, L., Magnani, I., Pollo, B., Cirenei, N., Giani, C., Conti, A. M. F., DiDonato, S., and Finocchiaro, G. Deletion mapping of gliomas suggests the presence of two small regions for candidate tumor-suppressor genes in a 17-cM interval on chromosome 10q. Am. J. Hum. Genet., 58: 1260-1267, 1996.
10. Rasheed, B. K. A., Fuller, G. N., Friedman, A. H., Darrel, D., Bigner, D. D. and Bigner, S. H. Loss of heterozygosity for 10q loci in human gliomas. Genes Chromosomes & Cancer, 5: 75-82, 1992.
11. Karlbom, A. E., James, C. D., Boethius, J., Cavenee, W. K., Collins, V. P., Norden-Skjöld M., and Larsson, C. Loss of heterozygosity in malignant gliomas involves at least three distinct regions on chromosome 10. Hum. Genet., 92: 169-174, 1993.
12. von Deimling, A., Louis, D. N., von Ammon, K., Petersen, I., Hoell, T., Chung, R. Y., Martuza, R. L., Schoenfeld, D. A., Yasargil, G., Wiestler, O. D., and Seizinger, B. R. Association of epidermal growth factor receptor gene amplification with loss of chromosome 10 in human glioblastoma multiforme. J. Neurosurg., 77: 295-301, 1992.
13. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M. H., and Parsons, R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (Washington DC), 275: 1943-1947, 1997.
14. Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K. A., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D. H. F., and Tavtigian, S. V. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet., 15: 356-362, 1997.
15. Li, D., and Sun, H. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor β. Cancer Res., 57: 2124-2129, 1997.
16. Liaw, D., Marsh, D. J., Li, J., Dahia, D. L. M., Wang, S. I., Zheng, Z., Bose, S., Call, K. M., Tsou, H. C., Peacocke, M., Eng, C., and Parsons, R. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet., 16: 64-67, 1997.
17. Moulton, T., Samara, G., Chung, W. Y., Yuan, L., Desai, R., Sisti, M., Bruce, J., and Tycko, B. MTS1/p16/CDKN2 lesions in primary glioblastoma multiforme. Am. J. Pathol., 146: 613-619, 1995.
18. Hudson, T. J., Stein, L. D., Gerety, S. S., Ma. J., Castle, A. B., Silva, J., Slonim, D. K., Baptista, R., Druglyak, L., Xu, S. H., Hu, X., Colbert, A. M. E., Rosenberg, C., Reeve-Daly, M. P., Rozen, S., Hui, L., Wu, X., Vestergaard, C., Wilson, K. M., Bae, J. S., Maitra, S., Ganiatsas, S., Evans, C. A., DeAngelis, M. M., Ingalls, K. A., Nahf, R. W., Horton, L. T., Jr., Anderson, M. O., Collymore, A. J., Ye, W., Kouyoumjian, V., Zemsteva, I. S., Tam, J., Devine, R., Courtney, D. F., Renaud, M. T., Nguyen, H., O'Connor, T. J., Fizames, C., Faure, S., Gyapay, G., Dib, C., Morissette, J., Orlin, J. B., Birren, B. W., Goodman, N., Weissenbach, J., Hawkins, T. L., Foote, S., Page, D. C., and Landers, E. S. An STS-based map of the human genome. Science (Washington DC), 270: 1945-1954, 1995.
19. Cairns, P., Polascik, T. J., Eby, Y., Tokino, K., Califano, J., Merlo, A., Mao, L., Herath, J., Jenkins, R., Westra, W., Rutter, J. L., Buckler, A., Gabrielson, E., Tockman, M., Cho, K. R., Hedrick, L., Bova, G. S., Isaacs, W., Koch, W., Schwab, D., and Sidransky, D. Frequency of homozygous deletion at p16/CDKN2 in primary human tumours. Nat. Genet., 11: 210-212, 1995.