The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex

Nature Cell Biology

Volumn 6, Issue 2, 2004, Pages 129-137

  Song, Min Sup ^a,b   Song, Su Jeong ^a   Ayad, Nagi G ^c   Chang, Jin Sook ^a   Lee, Joo Hyun ^a   Hong, Hyun Kyung ^a   Lee, Ho ^a   Choi, Naeyun ^d   Kim, Jhingook ^d   Kim, Hojoong ^d   Kim, Jin Woo ^b   Choi, Eui Ju ^b   Kirschner, Marc W ^c   Lim, Dae Sik ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Korea University   (South Korea)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Samsung Medical Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; CELL CYCLE PROTEIN 20; CYCLINE; PROTEIN MAD2; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; RNA; ANAPHASE PROMOTING COMPLEX; ANAPHASE-PROMOTING COMPLEX; CDC20 PROTEIN, HUMAN; CDC20 PROTEIN, MOUSE; CELL CYCLE PROTEIN; HYBRID PROTEIN; RASSF1 PROTEIN, HUMAN; SMALL INTERFERING RNA; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CELL DIVISION; CENTROSOME; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTERPHASE; METAPHASE; MICROTUBULE; MITOSIS; MITOSIS INHIBITION; MITOSIS SPINDLE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RNA INTERFERENCE; TUMOR SUPPRESSOR GENE; ANIMAL; CELL LINE; GENE VECTOR; GENETICS; METABOLISM; MOUSE; NUDE MOUSE; PHYSIOLOGY;

ANIMALS; CELL CYCLE PROTEINS; CELL LINE; GENETIC VECTORS; HUMANS; MICE; MICE, NUDE; MICROTUBULES; MITOSIS; RECOMBINANT FUSION PROTEINS; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

EID: 1642602695     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1091     Document Type: Article

References (30)

1. Dammann, R. et al. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nature Genet. 25, 315-319 (2000).
2. Astuti, D. et al. RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastoma tumours. Oncogene 20, 7573-7577 (2001).
3. Burbee, D. G. et al. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. J. Natl. Cancer Inst. 93, 691-699 (2001).
4. Dammann, R., Takahashi, T. & Pfeifer, G. P. The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas. Oncogene 20, 3563-3567 (2001).
5. Dreijerink, K. et al. The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis. Proc. Natl Acad. Sci. USA 98, 7504-7509 (2001).
6. Lo, K. W. et al. High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma. Cancer Res. 61, 3877-3881 (2001).
7. King, R. W., Deshaies, R. J., Peters, J. M. & Kirschner, M. W. How proteolysis drives the cell cycle. Science 274, 1652-1659 (1996).
8. Zachariae, W. & Nasmyth, K. Whose end is destruction: Cell division and the anaphase-promoting complex. Genes Dev. 13, 2039-2058 (1999).
9. Jallepalli, P. V. & Lengauer, C. Chromosome segregation and cancer: Cutting through the mystery. Nature Rev. Cancer 1, 109-117 (2001).
10. Peters, J. M. The anaphase-promoting complex: Proteolysis in mitosis and beyond. Mol. Cell 9, 931-943 (2002).
11. Visintin, R., Prinz, S. & Amon, A. CDC20 and CDH1: A family of substrate-specific activators of APC-dependent proteolysis. Science 278, 460-463 (1997).
12. Reimann, J. D., Gardner, B. E., Margottin-Goguet, F. & Jackson, P. K. Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins. Genes Dev. 15, 3278-3285 (2001).
13. Reimann, J. D. et al. Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Cell 105, 645-655 (2001).
14. Hsu, J. Y., Reimann, J. D., Sorensen, C. S., Lukas, J. & Jackson, P. K. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). Nature Cell Biol. 4, 358-366 (2002).
15. Vos, M. D., Ellis, C. A., Bell, A., Birrer, M. J. & Clark, G. J. Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis. J. Biol. Chem. 275, 35669-35672 (2000).
16. Shivakumar, L., Minna, J., Sakamaki, T., Pestell, R. & White, M. A. The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation. Mol. Cell. Biol. 22, 4309-4318 (2002).
17. Margottin-Goguet, F. et al. Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. Dev. Cell 4, 813-826 (2003).
18. Zhang, Y. & Lees, E. Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: Model for spindle checkpoint regulation. Mol. Cell. Biol. 21, 5190-5199 (2001).
19. Brummelkamp, T. R., Bernards, R. & Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550-553 (2002).
20. Luo, X., Tang, Z., Rizo, J. & Yu, H. The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Mol. Cell 9, 59-71 (2002).
21. Martin-Lluesma, S., Stucke, V. M. & Nigg, E. A. Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science 297, 2267-2270 (2002).
22. Guardavaccaro, D. et al. Control of meiotic and mitotic progression by the F box protein β-Trcp1 in vivo. Dev. Cell 4, 799-812 (2003).
23. Raff, J. W., Jeffers, K. & Huang, J. Y. The roles of Fzy/Cdc20 and Fzr/Cdh1 in regulating the destruction of cyclin B in space and time. J. Cell Biol. 157, 1139-1149 (2002).
24. Cahill, D. P. et al. Mutations of mitotic checkpoint genes in human cancers. Nature 392, 300-303 (1998).
25. Fodde, R. et al. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nature Cell Biol. 3, 433-438 (2001).
26. Kaplan, K. B. et al. A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nature Cell Biol. 3, 429-432 (2001).
27. Jallepalli, P. V. et al. Securin is required for chromosomal stability in human cells. Cell 105, 445-457 (2001).
28. Lim, D. S. et al. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 404, 613-617 (2000).
29. Fang, G., Yu, H. & Kirschner, M. W. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes Dev. 12, 1871-1883 (1998).
30. Buschmann, T., Fuchs, S. Y., Lee, C. G., Pan, Z. Q. & Ronai, Z. SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53. Cell 101, 753-762 (2000).