Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 9, 2004, Pages 3089-3094

  Wang, Tian Li ^a   Diaz Jr , Luis A ^a   Romans, Katharine ^a   Bardelli, Alberto ^a   Saha, Saurabh ^a   Galizia, Gennaro ^c   Choti, Michael ^a   Donehower, Ross ^a   Parmigiani, Giovanni ^a   Shih, Ie Ming ^a   Iacobuzio Donahue, Christine ^a   Kinzler, Kenneth W ^a,b   Vogelstein, Bert ^a,b   Lengauer, Christoph ^a   Velculescu, Victor E ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; THYMIDYLATE SYNTHASE;

ADVANCED CANCER; ARTICLE; CANCER CHEMOTHERAPY; CANCER MORTALITY; CANCER RECURRENCE; CANCER SURVIVAL; CHROMOSOME 18P; COLORECTAL CANCER; CONTROLLED STUDY; DIGITAL KARYOTYPING; DRUG RESISTANCE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENOME; HUMAN; HUMAN CELL; HUMAN TISSUE; KARYOTYPING; LIVER METASTASIS; METASTASIS; PRIORITY JOURNAL;

AUTOMATIC DATA PROCESSING; CHROMOSOMES, HUMAN, PAIR 18; COLORECTAL NEOPLASMS; DNA, NEOPLASM; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; FOLLOW-UP STUDIES; GENE LIBRARY; HUMANS; KARYOTYPING; LIVER NEOPLASMS; NEOPLASM METASTASIS; SURVIVAL ANALYSIS; THYMIDYLATE SYNTHASE; TIME FACTORS;

EID: 12144290775     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0308716101     Document Type: Article

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