Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

Molecular Biology of the Cell

Volumn 13, Issue 3, 2002, Pages 755-766

  Fang, Guowei ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE PROMOTING COMPLEX; BUB1 RELATED PROTEIN; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 20; PROTEIN MAD2; UNCLASSIFIED DRUG;

ANAPHASE; ARTICLE; CENTROMERE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MICROTUBULE; MITOSIS INHIBITION; MITOSIS SPINDLE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; SISTER CHROMATID;

ANTINEOPLASTIC AGENTS; CALCIUM-BINDING PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CELL FRACTIONATION; CHROMATIDS; HELA CELLS; HUMANS; LIGASES; MACROMOLECULAR SUBSTANCES; NOCODAZOLE; PROTEIN BINDING; PROTEIN KINASES; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

EID: 0036199862     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.01-09-0437     Document Type: Article

References (38)

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3. Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1
4. MAD2B is an inhibitor of the anaphase-promoting complex
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10. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
11. Mitotic proteolysis
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13. Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption
14. Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells
15. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
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17. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1
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22. Identification of a human mitotic checkpoint gene: hsMAD2
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30. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2
31. Mad2-independent inhibition of APC-Cdc20 by the mitotic checkpoint protein BubR1
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35. Mad2 transiently associates with an APC/p55Cdc complex during mitosis
36. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension
37. p55CDC/hCDC20 is associated with BUBR1, and may be a downstream target of the spindle checkpoint kinase
38. CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint