메뉴 건너뛰기




Volumn 4, Issue 3, 2005, Pages 173-196

Behavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease

Author keywords

secretase; secretase; A ; Alzheimer's disease; Amyloid; APP; Behavior; Presenilin; Transgenic mouse models

Indexed keywords

ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; AMYLOID PROTEIN; BETA SECRETASE; PRESENILIN 1; PRESENILIN 2; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

EID: 17644370721     PISSN: 16011848     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2005.00124.x     Document Type: Review
Times cited : (160)

References (119)
  • 1
    • 0030974261 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation
    • Almkvist, O., Basun, H., Wagner, S.L., Rowe, B.A., Wahlund, L.O. & Lannfelt, L. (1997) Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation. Arch Neurol 54, 641-644.
    • (1997) Arch Neurol , vol.54 , pp. 641-644
    • Almkvist, O.1    Basun, H.2    Wagner, S.L.3    Rowe, B.A.4    Wahlund, L.O.5    Lannfelt, L.6
  • 2
    • 0032768748 scopus 로고    scopus 로고
    • Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: Correlation with spatial memory deficits
    • Anderson, J.J., Holtz, G., Baskin, P.P., Wang, R., Mazzarelli, L., Wagner, S.L. & Menzaghi, F. (1999) Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits. Neuroscience 93, 1409-1420.
    • (1999) Neuroscience , vol.93 , pp. 1409-1420
    • Anderson, J.J.1    Holtz, G.2    Baskin, P.P.3    Wang, R.4    Mazzarelli, L.5    Wagner, S.L.6    Menzaghi, F.7
  • 3
    • 0037088959 scopus 로고    scopus 로고
    • Intra- and intertask relationships in a behavioral test battery given to Tg2576 transgenic mice and controls
    • Arendash, G.W. & King, D.L. (2002) Intra- and intertask relationships in a behavioral test battery given to Tg2576 transgenic mice and controls. Physiol Behav 75, 643-652.
    • (2002) Physiol Behav , vol.75 , pp. 643-652
    • Arendash, G.W.1    King, D.L.2
  • 4
    • 0035830686 scopus 로고    scopus 로고
    • Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes
    • Arendash, G.W., King, D.L., Gordon, M.N., Morgan, D., Hatcher, J.M., Hope, C.E. & Diamond, D.M. (2001) Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes. Brain Res 891, 42-53.
    • (2001) Brain Res , vol.891 , pp. 42-53
    • Arendash, G.W.1    King, D.L.2    Gordon, M.N.3    Morgan, D.4    Hatcher, J.M.5    Hope, C.E.6    Diamond, D.M.7
  • 5
    • 0026595194 scopus 로고
    • Beta-amyloid protein immunoreactivity in muscle of patients with inclusion-body myositis
    • Askanas, V.E.W., Alvarez, R.B. & Glenner, G.G. (1992) Beta-amyloid protein immunoreactivity in muscle of patients with inclusion-body myositis. Lancet 29, 560-561.
    • (1992) Lancet , vol.29 , pp. 560-561
    • Askanas, V.E.W.1    Alvarez, R.B.2    Glenner, G.G.3
  • 6
    • 0038240645 scopus 로고    scopus 로고
    • Short-term beta-amyloid vaccinations do not improve cognitive performance in cognitively impaired APP + PS1 mice
    • Austin, L., Arendash, G.W., Gordon, M.N., Diamond, D.M., DiCarlo, G., Dickey, C., Ugen, K. & Morgan, D. (2003) Short-term beta-amyloid vaccinations do not improve cognitive performance in cognitively impaired APP + PS1 mice. Behav Neurosci 117, 478-484.
    • (2003) Behav Neurosci , vol.117 , pp. 478-484
    • Austin, L.1    Arendash, G.W.2    Gordon, M.N.3    Diamond, D.M.4    DiCarlo, G.5    Dickey, C.6    Ugen, K.7    Morgan, D.8
  • 7
    • 0141457931 scopus 로고    scopus 로고
    • Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease
    • Beckmann, N., Schuler, A., Mueggler, T., Meyer, E.P., Wiederhold, K.H., Staufenbiel, M. & Krucker, T. (2003) Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease. J Neurosci 23, 8453-8459.
    • (2003) J Neurosci , vol.23 , pp. 8453-8459
    • Beckmann, N.1    Schuler, A.2    Mueggler, T.3    Meyer, E.P.4    Wiederhold, K.H.5    Staufenbiel, M.6    Krucker, T.7
  • 9
    • 0346250096 scopus 로고    scopus 로고
    • Comparative localization of ADAMs 10 and 15 in human cerebral cortex normal aging, Alzheimer disease and down syndrome
    • Bernstein, H.G., Bukowska, A., Krell, D., Bogerts, B., Ansorge, S. & Lendeckel, U. (2003) Comparative localization of ADAMs 10 and 15 in human cerebral cortex normal aging, Alzheimer disease and down syndrome. J Neurocytol 32, 153-160.
    • (2003) J Neurocytol , vol.32 , pp. 153-160
    • Bernstein, H.G.1    Bukowska, A.2    Krell, D.3    Bogerts, B.4    Ansorge, S.5    Lendeckel, U.6
  • 11
    • 14444272986 scopus 로고    scopus 로고
    • Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
    • Buxbaum, J.D., Liu, K.N., Luo, Y., Slack, J.L., Stocking, K.L., Peschon, J.J., Johnson, R.S., Castner, B.J., Cerretti, D.P. & Black, R.A. (1998) Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J Biol Chem 273, 27765-27767.
    • (1998) J Biol Chem , vol.273 , pp. 27765-27767
    • Buxbaum, J.D.1    Liu, K.N.2    Luo, Y.3    Slack, J.L.4    Stocking, K.L.5    Peschon, J.J.6    Johnson, R.S.7    Castner, B.J.8    Cerretti, D.P.9    Black, R.A.10
  • 16
    • 0035877756 scopus 로고    scopus 로고
    • Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
    • Chishti, M.A., Yang, D.S., Janus, C. et al. (2001) Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem 276, 21562-21570.
    • (2001) J Biol Chem , vol.276 , pp. 21562-21570
    • Chishti, M.A.1    Yang, D.S.2    Janus, C.3
  • 18
    • 0036743625 scopus 로고    scopus 로고
    • Over-expression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease
    • Corcoran, K.A., Lu, Y., Turner, R.S. & Maren, S. (2002) Over-expression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease. Learn Mem 9, 243-252.
    • (2002) Learn Mem , vol.9 , pp. 243-252
    • Corcoran, K.A.1    Lu, Y.2    Turner, R.S.3    Maren, S.4
  • 19
    • 0037431082 scopus 로고    scopus 로고
    • Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex
    • De Strooper, B. (2003) Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex. Neuron 38, 9-12.
    • (2003) Neuron , vol.38 , pp. 9-12
    • De Strooper, B.1
  • 21
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • DeMattos, R.B., Bales, K.R., Cummins, D.J., Dodart, J.C., Paul, S.M. & Holtzman, D.M. (2001) Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 98, 8850-8855.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 23
    • 0037151046 scopus 로고    scopus 로고
    • Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins
    • Dineley, K.T., Xia, X., Bui, D., Sweatt, J.D. & Zheng, H. (2002) Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. J Biol Chem 277, 22768-22780.
    • (2002) J Biol Chem , vol.277 , pp. 22768-22780
    • Dineley, K.T.1    Xia, X.2    Bui, D.3    Sweatt, J.D.4    Zheng, H.5
  • 25
    • 0034107615 scopus 로고    scopus 로고
    • Neuroanatomical abnormalities in behaviorally characterized APP (V717F) transgenic mice
    • Dodart, J.C., Mathis, C., Saura, J., Bales, K.R., Paul, S.M. & Ungerer, A. (2000) Neuroanatomical abnormalities in behaviorally characterized APP (V717F) transgenic mice. Neurobiol Dis 7, 71-85.
    • (2000) Neurobiol Dis , vol.7 , pp. 71-85
    • Dodart, J.C.1    Mathis, C.2    Saura, J.3    Bales, K.R.4    Paul, S.M.5    Ungerer, A.6
  • 26
    • 0033501744 scopus 로고    scopus 로고
    • Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein
    • Dodart, J.C., Meziane, H., Mathis, C., Bales, K.R., Paul, S.M. & Ungerer, A. (1999) Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein. Behav Neurosci 113, 982-990.
    • (1999) Behav Neurosci , vol.113 , pp. 982-990
    • Dodart, J.C.1    Meziane, H.2    Mathis, C.3    Bales, K.R.4    Paul, S.M.5    Ungerer, A.6
  • 28
    • 0036718272 scopus 로고    scopus 로고
    • Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease
    • Fukumoto, H., Cheung, B.S., Hyman, B.T. & Irizarry, M.C. (2002) Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. Arch Neurol 59, 1381-1389.
    • (2002) Arch Neurol , vol.59 , pp. 1381-1389
    • Fukumoto, H.1    Cheung, B.S.2    Hyman, B.T.3    Irizarry, M.C.4
  • 29
    • 1542349913 scopus 로고    scopus 로고
    • Beta-secretase activity increases with aging in human, monkey, and mouse brain
    • Fukumoto, H., Rosene, D.L., Moss, M.B., Raju, S., Hyman, B.T. & Irizarry, M.C. (2004) Beta-secretase activity increases with aging in human, monkey, and mouse brain. Am J Pathol 164, 719-725.
    • (2004) Am J Pathol , vol.164 , pp. 719-725
    • Fukumoto, H.1    Rosene, D.L.2    Moss, M.B.3    Raju, S.4    Hyman, B.T.5    Irizarry, M.C.6
  • 30
    • 0029841562 scopus 로고    scopus 로고
    • Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain
    • Furukawa, K., Sopher, B.L., Rydel, R.E., Begley, J.G., Pham, D.G., Martin, G.M., Fox, M. & Mattson, M.P. (1996) Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain. J Neurochem 67, 1882-1896.
    • (1996) J Neurochem , vol.67 , pp. 1882-1896
    • Furukawa, K.1    Sopher, B.L.2    Rydel, R.E.3    Begley, J.G.4    Pham, D.G.5    Martin, G.M.6    Fox, M.7    Mattson, M.P.8
  • 32
    • 0037112079 scopus 로고    scopus 로고
    • Behavioral impairment of APP(V717F) mice in fear conditioning: Is it only cognition?
    • Gerlai, R., Fitch, T., Bales, K.R. & Gitter, B.D. (2002) Behavioral impairment of APP(V717F) mice in fear conditioning: is it only cognition? Behav Brain Res 136, 503-509.
    • (2002) Behav Brain Res , vol.136 , pp. 503-509
    • Gerlai, R.1    Fitch, T.2    Bales, K.R.3    Gitter, B.D.4
  • 33
    • 0021207461 scopus 로고
    • Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
    • Glenner, G.G. & Wong, C.W. (1984) Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 122, 1131-1135.
    • (1984) Biochem Biophys Res Commun , vol.122 , pp. 1131-1135
    • Glenner, G.G.1    Wong, C.W.2
  • 34
    • 0035828139 scopus 로고    scopus 로고
    • Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease
    • Gonzalez-Lima, F., Berndt, J.D., Valla, J.E., Games, D. & Reiman, E.M. (2001) Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease. Neuroreport 12, 2375-2379.
    • (2001) Neuroreport , vol.12 , pp. 2375-2379
    • Gonzalez-Lima, F.1    Berndt, J.D.2    Valla, J.E.3    Games, D.4    Reiman, E.M.5
  • 36
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy, J.A. & Higgins, G.A. (1992) Alzheimer's disease: the amyloid cascade hypothesis. Science 256, 184-185.
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 39
    • 0042362874 scopus 로고    scopus 로고
    • Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease
    • Haughey, N.J., Nath, A., Chan, S.L., Borchard, A.C., Rao, M.S. & Mattson, M.P. (2002) Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease. J Neurochem 83, 1509-1524.
    • (2002) J Neurochem , vol.83 , pp. 1509-1524
    • Haughey, N.J.1    Nath, A.2    Chan, S.L.3    Borchard, A.C.4    Rao, M.S.5    Mattson, M.P.6
  • 41
    • 0032756213 scopus 로고    scopus 로고
    • Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: Lack of association with amyloid deposits
    • Holcomb, L.A., Gordon, M.N., Jantzen, P., Hsiao, K., Duff, K. & Morgan, D. (1999) Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits. Behav Genet 29, 177-185.
    • (1999) Behav Genet , vol.29 , pp. 177-185
    • Holcomb, L.A.1    Gordon, M.N.2    Jantzen, P.3    Hsiao, K.4    Duff, K.5    Morgan, D.6
  • 44
    • 0028810244 scopus 로고
    • Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins
    • Hsiao, K.K., Borchelt, D.R., Olson, K., Johannsdottir, R., Kitt, C., Yunis, W., Xu, S., Eckman, C., Younkin, S. & Price, D. (1995) Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron 15, 1203-1218.
    • (1995) Neuron , vol.15 , pp. 1203-1218
    • Hsiao, K.K.1    Borchelt, D.R.2    Olson, K.3    Johannsdottir, R.4    Kitt, C.5    Yunis, W.6    Xu, S.7    Eckman, C.8    Younkin, S.9    Price, D.10
  • 45
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
    • Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F. & Cole, G. (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274, 99-102.
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, S.6    Yang, F.7    Cole, G.8
  • 46
    • 0141448940 scopus 로고    scopus 로고
    • Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235
    • Huang, X.G., Yee, B.K., Nag, S., Chan, S.T. & Tang, F. (2003) Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235. Exp Neurol 183, 673-681.
    • (2003) Exp Neurol , vol.183 , pp. 673-681
    • Huang, X.G.1    Yee, B.K.2    Nag, S.3    Chan, S.T.4    Tang, F.5
  • 48
    • 0034702303 scopus 로고    scopus 로고
    • Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
    • Huppert, S.S., Le, A., Schroeter, E.H., Mumm, J.S., Saxena, M.T., Milner, L.A. & Kopan, R. (2000) Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature 405, 966-970.
    • (2000) Nature , vol.405 , pp. 966-970
    • Huppert, S.S.1    Le, A.2    Schroeter, E.H.3    Mumm, J.S.4    Saxena, M.T.5    Milner, L.A.6    Kopan, R.7
  • 51
    • 0030611097 scopus 로고    scopus 로고
    • Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse
    • Irizarry, M.C., Soriano, F., McNamara, M., Page, K.J., Schenk, D., Games, D. & Hyman, B.T. (1997) Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J Neurosci 17, 7053-7059.
    • (1997) J Neurosci , vol.17 , pp. 7053-7059
    • Irizarry, M.C.1    Soriano, F.2    McNamara, M.3    Page, K.J.4    Schenk, D.5    Games, D.6    Hyman, B.T.7
  • 54
    • 0001607842 scopus 로고    scopus 로고
    • Behavioral characterization of PDAPP Alzheimer mice
    • Justice, A. & Motter, R. (1997) Behavioral characterization of PDAPP Alzheimer mice. Soc Neurosci 23, 1637.
    • (1997) Soc Neurosci , vol.23 , pp. 1637
    • Justice, A.1    Motter, R.2
  • 56
    • 0343628678 scopus 로고    scopus 로고
    • Metalloprotease-disintegrin (ADAM) genes are widely and differentially expressed in the adult CNS
    • Karkkainen, I., Rybnikova, E., Pelto-Huikko, M., Huovila & A.P. (2000) Metalloprotease-disintegrin (ADAM) genes are widely and differentially expressed in the adult CNS. Mol Cell Neurosci 15, 547-560.
    • (2000) Mol Cell Neurosci , vol.15 , pp. 547-560
    • Karkkainen, I.1    Rybnikova, E.2    Pelto-Huikko, M.3    Huovila, A.P.4
  • 59
    • 0037088956 scopus 로고    scopus 로고
    • Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19months
    • King, D.L. & Arendash, G.W. (2002a) Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19months. Physiol Behav 75, 627-642.
    • (2002) Physiol Behav , vol.75 , pp. 627-642
    • King, D.L.1    Arendash, G.W.2
  • 60
    • 0036468268 scopus 로고    scopus 로고
    • Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging; correlations with cognitive impairment
    • King, D.L. & Arendash, G.W. (2002b) Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging; correlations with cognitive impairment. Brain Res 326, 58-68.
    • (2002) Brain Res , vol.326 , pp. 58-68
    • King, D.L.1    Arendash, G.W.2
  • 61
    • 0033199822 scopus 로고    scopus 로고
    • Progressive and gender-dependent cognitive impairment in the APP (SW) transgenic mouse model for Alzheimer's disease
    • King, D.L., Arendash, G.W., Crawford, F., Sterk, T., Menendez, J. & Mullan, M.J. (1999) Progressive and gender-dependent cognitive impairment in the APP (SW) transgenic mouse model for Alzheimer's disease, Behav Brain Res 103, 145-162.
    • (1999) Behav Brain Res , vol.103 , pp. 145-162
    • King, D.L.1    Arendash, G.W.2    Crawford, F.3    Sterk, T.4    Menendez, J.5    Mullan, M.J.6
  • 63
    • 3042536719 scopus 로고    scopus 로고
    • Postsynaptic signaling of new players at the neuromuscular junction
    • Lai, K.O. & Ip, N.Y. (2003) Postsynaptic signaling of new players at the neuromuscular junction. J Neurocytol 32, 727-741.
    • (2003) J Neurocytol , vol.32 , pp. 727-741
    • Lai, K.O.1    Ip, N.Y.2
  • 64
    • 0037159635 scopus 로고    scopus 로고
    • Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation
    • Lalonde, R., Dumont, M., Staufenbiel, M., Sturchler-Pierrat, C. & Strazielle, C. (2002) Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation. Brain Res 956, 36-44.
    • (2002) Brain Res , vol.956 , pp. 36-44
    • Lalonde, R.1    Dumont, M.2    Staufenbiel, M.3    Sturchler-Pierrat, C.4    Strazielle, C.5
  • 65
    • 0037421111 scopus 로고    scopus 로고
    • Transgenic mice expressing the PS1-A246E mutation: Effects on spatial learning, exploration, anxiety, and motor coordination
    • Lalonde, R., Qian, S. & Strazielle, C. (2003a) Transgenic mice expressing the PS1-A246E mutation: effects on spatial learning, exploration, anxiety, and motor coordination. Behav Brain Res 138, 71-79.
    • (2003) Behav Brain Res , vol.138 , pp. 71-79
    • Lalonde, R.1    Qian, S.2    Strazielle, C.3
  • 66
    • 0038022595 scopus 로고    scopus 로고
    • Transgenic mice expressing the betaAPP695SWE mutation: Effects on exploratory activity, anxiety, and motor coordination
    • Lalonde, R., Lewis, T.L., Strazielle, C., Kim, H. & Fukuchi, K. (2003b) Transgenic mice expressing the betaAPP695SWE mutation: effects on exploratory activity, anxiety, and motor coordination. Brain Res 977, 38-45.
    • (2003) Brain Res , vol.977 , pp. 38-45
    • Lalonde, R.1    Lewis, T.L.2    Strazielle, C.3    Kim, H.4    Fukuchi, K.5
  • 68
    • 0033616716 scopus 로고    scopus 로고
    • Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
    • Lammich, S., Kojro, E., Postina, R., Gilbert, S., Pfeiffer, R., Jasionowski, M., Haass, C. & Fahrenholz, F. (1999) Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci USA 96, 3922-3927.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3922-3927
    • Lammich, S.1    Kojro, E.2    Postina, R.3    Gilbert, S.4    Pfeiffer, R.5    Jasionowski, M.6    Haass, C.7    Fahrenholz, F.8
  • 69
    • 0033523480 scopus 로고    scopus 로고
    • Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice
    • Larson, J., Lynch, G., Games, D. & Seubert, P. (1999) Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice. Brain Res 840, 23-35.
    • (1999) Brain Res , vol.840 , pp. 23-35
    • Larson, J.1    Lynch, G.2    Games, D.3    Seubert, P.4
  • 71
    • 0037454478 scopus 로고    scopus 로고
    • Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice
    • Liu, L., Tapiola, T., Herukka, S.K., Heikkila, M. & Tanila, H. (2003) Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice. Neuroreport 14, 163-166.
    • (2003) Neuroreport , vol.14 , pp. 163-166
    • Liu, L.1    Tapiola, T.2    Herukka, S.K.3    Heikkila, M.4    Tanila, H.5
  • 72
    • 0042334543 scopus 로고    scopus 로고
    • BACE1 (betα-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time
    • Luo, Y., Bolon, B., Damore, M.A., Fitzpatrick, D., Liu, H., Zhang, J., Yan, Q., Vassar, R. & Citron, M. (2003) BACE1 (betα-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time. Neurobiol Dis 14, 81-88.
    • (2003) Neurobiol Dis , vol.14 , pp. 81-88
    • Luo, Y.1    Bolon, B.2    Damore, M.A.3    Fitzpatrick, D.4    Liu, H.5    Zhang, J.6    Yan, Q.7    Vassar, R.8    Citron, M.9
  • 74
    • 0029813177 scopus 로고    scopus 로고
    • Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease
    • Masliah, E., Sisk, A., Mallory, M., Mucke, L., Schenk, D. & Games, D. (1996) Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease. J Neurosci 16, 5795-5811.
    • (1996) J Neurosci , vol.16 , pp. 5795-5811
    • Masliah, E.1    Sisk, A.2    Mallory, M.3    Mucke, L.4    Schenk, D.5    Games, D.6
  • 76
    • 0030779677 scopus 로고    scopus 로고
    • Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
    • Mattson, M.P. (1997) Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol Rev 77, 1081-1132.
    • (1997) Physiol Rev , vol.77 , pp. 1081-1132
    • Mattson, M.P.1
  • 77
    • 0344875100 scopus 로고    scopus 로고
    • Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein
    • McCool, M.F., Varty, G.B., Del Vecchio, R.A., Kazdoba, T.M., Parker, E.M., Hunter, J.C. & Hyde, L.A. (2003) Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein. Brain Res 994, 99-106.
    • (2003) Brain Res , vol.994 , pp. 99-106
    • McCool, M.F.1    Varty, G.B.2    Del Vecchio, R.A.3    Kazdoba, T.M.4    Parker, E.M.5    Hunter, J.C.6    Hyde, L.A.7
  • 78
    • 0029917041 scopus 로고    scopus 로고
    • Expression in brain of amyloid precursor protein mutated in the alphα-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice
    • Moechars, D., Lorent, K., De Strooper, B., Dewachter, I. & Van Leuven, F. (1996) Expression in brain of amyloid precursor protein mutated in the alphα-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice. EMBO J 15, 1265-1274.
    • (1996) EMBO J , vol.15 , pp. 1265-1274
    • Moechars, D.1    Lorent, K.2    De Strooper, B.3    Dewachter, I.4    Van Leuven, F.5
  • 79
    • 0032953541 scopus 로고    scopus 로고
    • Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis
    • Moechars, D., Lorent, K. & Van Leuven, F. (1999) Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis. Neuroscience 91, 819-830.
    • (1999) Neuroscience , vol.91 , pp. 819-830
    • Moechars, D.1    Lorent, K.2    Van Leuven, F.3
  • 80
    • 1542313772 scopus 로고    scopus 로고
    • Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathology
    • Mohajeri, M.H., Saini, K.D. & Nitsch, R.M. (2004) Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathology. J Neural Transm 111, 413-425.
    • (2004) J Neural Transm , vol.111 , pp. 413-425
    • Mohajeri, M.H.1    Saini, K.D.2    Nitsch, R.M.3
  • 84
    • 0346055155 scopus 로고    scopus 로고
    • BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease
    • Ohno, M., Sametsky, E.A., Younkin, L.H., Oakley, H., Younkin, S.G., Citron, M., Vassar, R. & Disterhoft, J.F. (2004) BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease. Neuron 41, 27-33.
    • (2004) Neuron , vol.41 , pp. 27-33
    • Ohno, M.1    Sametsky, E.A.2    Younkin, L.H.3    Oakley, H.4    Younkin, S.G.5    Citron, M.6    Vassar, R.7    Disterhoft, J.F.8
  • 85
    • 0042924399 scopus 로고    scopus 로고
    • Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits
    • Palop, J.J., Jones, B., Kekonius, L., Chin, J., Yu, G.Q., Raber, J., Masliah, E. & Mucke, L. (2003) Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits. Proc Natl Acad Sci USA 100, 9572-9577.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 9572-9577
    • Palop, J.J.1    Jones, B.2    Kekonius, L.3    Chin, J.4    Yu, G.Q.5    Raber, J.6    Masliah, E.7    Mucke, L.8
  • 87
    • 0035219699 scopus 로고    scopus 로고
    • Beta-amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice
    • Pettit, D.L., Shao, Z. & Yakel, J.L. (2001) Beta-amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice. J Neurosci 21, RC120.
    • (2001) J Neurosci , vol.21
    • Pettit, D.L.1    Shao, Z.2    Yakel, J.L.3
  • 88
    • 0033082456 scopus 로고    scopus 로고
    • Adaptation of the circular platform spatial memory task for mice: Use in detecting cognitive impairment in the APP (SW) transgenic mouse model for Alzheimer's disease
    • Pompl, P.N., Mullan, M.J., Bjugstad, K. & Arendash, G.W. (1999) Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APP (SW) transgenic mouse model for Alzheimer's disease. J Neurosci Methods 87, 87-95.
    • (1999) J Neurosci Methods , vol.87 , pp. 87-95
    • Pompl, P.N.1    Mullan, M.J.2    Bjugstad, K.3    Arendash, G.W.4
  • 90
    • 0024422765 scopus 로고
    • Hypothermia impairs performance in the Morris water maze
    • Rauch, T.M., Welch, D.I. & Gallego, L. (1989) Hypothermia impairs performance in the Morris water maze. Physiol Behav 46, 315-320.
    • (1989) Physiol Behav , vol.46 , pp. 315-320
    • Rauch, T.M.1    Welch, D.I.2    Gallego, L.3
  • 91
    • 17344388652 scopus 로고    scopus 로고
    • BACE knockout mice are healthy despite lacking the primary betα-secretase activity in brain: Implications for Alzheimer's disease therapeutics
    • Roberds, S.L., Anderson, J., Basi, G. et al. (2001) BACE knockout mice are healthy despite lacking the primary betα-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum Mol Genet 10, 1317-1324.
    • (2001) Hum Mol Genet , vol.10 , pp. 1317-1324
    • Roberds, S.L.1    Anderson, J.2    Basi, G.3
  • 92
    • 1842288033 scopus 로고    scopus 로고
    • Measuring memory in a mouse model of Alzheimer's disease
    • Routtenberg, A. (1997) Measuring memory in a mouse model of Alzheimer's disease. Science 277, 839-841.
    • (1997) Science , vol.277 , pp. 839-841
    • Routtenberg, A.1
  • 93
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk, D., Barbour, R., Dunn, W. et al. (1999) Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173-177.
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3
  • 95
    • 0025753852 scopus 로고
    • The molecular pathology of Alzheimer's disease
    • Selkoe, D.J. (1991) The molecular pathology of Alzheimer's disease. Neuron 6, 487-498.
    • (1991) Neuron , vol.6 , pp. 487-498
    • Selkoe, D.J.1
  • 96
    • 0033987298 scopus 로고    scopus 로고
    • Levels of alpha- and betα-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients
    • Sennvik, K., Fastbom, J., Blomberg, M., Wahlund, L.O., Winblad, B. & Benedikz, E. (2000) Levels of alpha- and betα-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients. Neurosci Lett 278, 169-172.
    • (2000) Neurosci Lett , vol.278 , pp. 169-172
    • Sennvik, K.1    Fastbom, J.2    Blomberg, M.3    Wahlund, L.O.4    Winblad, B.5    Benedikz, E.6
  • 98
    • 0033518251 scopus 로고    scopus 로고
    • Purification and cloning of amyloid precursor protein betα-secretase from human brain
    • Sinha, S., Anderson, J.P., Barbour, R. et al. (1999) Purification and cloning of amyloid precursor protein betα-secretase from human brain. Nature 402, 537-540.
    • (1999) Nature , vol.402 , pp. 537-540
    • Sinha, S.1    Anderson, J.P.2    Barbour, R.3
  • 103
    • 0033872024 scopus 로고    scopus 로고
    • Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss
    • Takeuchi, A., Irizarry, M.C., Duff, K., Saido, T.C., Hsiao Ashe, K., Hasegawa, M., Mann, D.M., Hyman, B.T. & Iwatsubo, T. (2000) Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. Am J Pathol 157, 331-339.
    • (2000) Am J Pathol , vol.157 , pp. 331-339
    • Takeuchi, A.1    Irizarry, M.C.2    Duff, K.3    Saido, T.C.4    Hsiao Ashe, K.5    Hasegawa, M.6    Mann, D.M.7    Hyman, B.T.8    Iwatsubo, T.9
  • 105
    • 0033529031 scopus 로고    scopus 로고
    • Neuronal over-expression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport
    • Torroja, L., Chu, H., Kotovsky, I. & White, K. (1999) Neuronal over-expression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport. Curr Biol 9, 489-492.
    • (1999) Curr Biol , vol.9 , pp. 489-492
    • Torroja, L.1    Chu, H.2    Kotovsky, I.3    White, K.4
  • 107
    • 0033595706 scopus 로고    scopus 로고
    • Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
    • Vassar, R., Bennett, B.D., Babu-Khan, S. et al. (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741.
    • (1999) Science , vol.286 , pp. 735-741
    • Vassar, R.1    Bennett, B.D.2    Babu-Khan, S.3
  • 108
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • Walsh, D.M., Klyubin, I., Fadeeva, J.V., Cullen, W.K., Anwyl, R., Wolfe, M.S., Rowan, M.J. & Selkoe, D.J. (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535-539.
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6    Rowan, M.J.7    Selkoe, D.J.8
  • 110
    • 0036707528 scopus 로고    scopus 로고
    • Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis
    • Wei, W., Norton, D.D., Wang, X. & Kusiak, J.W. (2002) Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis. Brain 125, 2036-2043.
    • (2002) Brain , vol.125 , pp. 2036-2043
    • Wei, W.1    Norton, D.D.2    Wang, X.3    Kusiak, J.W.4
  • 112
    • 0036170534 scopus 로고    scopus 로고
    • Mice lacking the metalloproteinase-disintegrin MDC9 (ADAM9) have no major abnormalities during development to adult life
    • Weskamp, G., Cai, H., Brodie, T.A., Higashiyama, S., Manova, K., Ludwig, T. & Blobel, C.P. (2002) Mice lacking the metalloproteinase-disintegrin MDC9 (ADAM9) have no major abnormalities during development to adult life. Mol Cell Biol 22, 1537-1544.
    • (2002) Mol Cell Biol , vol.22 , pp. 1537-1544
    • Weskamp, G.1    Cai, H.2    Brodie, T.A.3    Higashiyama, S.4    Manova, K.5    Ludwig, T.6    Blobel, C.P.7
  • 114
    • 0030952217 scopus 로고    scopus 로고
    • Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42
    • Wild-Bode, C., Yamazaki, T., Capell, A., Leimer, U., Steiner, H., Ihara, Y. & Haass, C. (1997) Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42. J Biol Chem 272, 16085-16088.
    • (1997) J Biol Chem , vol.272 , pp. 16085-16088
    • Wild-Bode, C.1    Yamazaki, T.2    Capell, A.3    Leimer, U.4    Steiner, H.5    Ihara, Y.6    Haass, C.7
  • 116
    • 0033675163 scopus 로고    scopus 로고
    • Dissecting the behaviour of transgenic mice: Is it the mutation, the genetic background, or the environment?
    • Wolfer, D.P. & Lipp, H.P. (2000) Dissecting the behaviour of transgenic mice: is it the mutation, the genetic background, or the environment? Exp Physiol 85, 627-634.
    • (2000) Exp Physiol , vol.85 , pp. 627-634
    • Wolfer, D.P.1    Lipp, H.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.