Brain Aβ amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau

Journal of Pathology

Volumn 194, Issue 4, 2001, Pages 500-506

  Tomidokoro, Yasushi ^a   Harigaya, Yasuo ^b   Matsubara, Etsuro ^a   Ikeda, Masaki ^c   Kawarabayashi, Takeshi ^a   Shirao, Tomoaki ^a   Ishiguro, Koichi ^b   Okamoto, Koichi ^c   Younkin, Steven G ^a   Shoji, Mikio ^b  

^a GUNMA UNIVERSITY   (Japan)

^b MAYO CLINIC   (United States)

^c MITSUBISHI KASEI INST OF LIFE SCI   (Japan)

Author keywords

Alzheimer's disease; Brain A amyloidosis; Drebrin; Hyperphosphorylated tau; Presenilin 1; Transgenic mice; synuclein; APP

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID; AMYLOID PRECURSOR PROTEIN; CELL PROTEIN; CONGO RED; MUTANT PROTEIN; PRESENILIN 1; TAU PROTEIN; MEMBRANE PROTEIN;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN DISEASE; CELL COUNT; CELL LOSS; CONTROLLED STUDY; DYSTROPHY; MENTAL DISEASE; MOUSE; NERVE CELL; NEURITE; NISSL STAINING; NONHUMAN; PATHOLOGY; POSTSYNAPTIC MEMBRANE; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SENILE PLAQUE; SYNAPSE; TRANSGENIC MOUSE; AMYLOID NEUROPATHY; ANIMAL; DISEASE MODEL; GENETICS; METABOLIC ENCEPHALOPATHY; METABOLISM; MUTATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID NEUROPATHIES; ANIMALS; BRAIN DISEASES, METABOLIC, INBORN; DISEASE MODELS, ANIMAL; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; NEURITES; PRESENILIN-1; SENILE PLAQUES; TAU PROTEINS;

EID: 0034741928     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.897     Document Type: Article

References (27)

1. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and βAPP mutations linked to familial Alzheimer's disease
2. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
3. APPsw transgenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1
4. Accumulation of β-amyloid fibrils in pancreas of transgenic mice
5. Modified amyloid β protein ending at 42 or 40 with different solubility accumulates in the brain of Alzheimer's disease
6. Carboxyl-terminal fragments of presenilin-1 are closely related to cytoskeletal abnormalities in Alzheimer's brains
7. Analysis of phosphorylation of tau with antibodies specific for phosphorylation sites
8. Phosphorylated tau in human cerebrospinal fluid is a diagnostic marker for Alzheimer's disease
9. Accumulation of NACP/α-synuclein in Lewy body disease and multiple system atrophy
10. Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease
11. Distinctive, rapid, and easy labeling of diffuse plaques in the Alzheimer brains by a new methenamine silver stain
12. Neurodegeneration and gliosis in transgenic mice overexpressing a carboxy-terminal fragment of Alzheimer amyloid-β protein precursor
13. Microglial response to amyloid plaques in APPsw transgenic mice
14. Amyloid β-protein precursor accumulates in dystrophic neurites of senile plaques in Alzheimer-type dementia
15. The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
16. Lewy bodies contain altered α-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes
17. Alzheimer patients and Down patients: Cerebral preamyloid deposits differ ultrastructually and histochemically from the amyloid of senile plaques
18. Water-soluble Aβ (N-40, N-42) oligomers in normal and Alzheimer disease brains
19. Morphology and toxicity of Aβ-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease
20. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
21. Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells
22. Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles
23. Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
24. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
25. Neurodegenerative Alzheimer-like pathology in PDAPP 717V→F transgenic mice
26. Neuron loss in APP transgenic mice
27. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology