-
1
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing
-
(2000)
Nature (London)
, vol.407
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arawaka, S.3
Levitan, D.4
Zhang, L.5
Tandon, A.6
Song, Y.-Q.7
Rogaeva, E.8
Chem, F.9
Kawaral, T.10
Supara, A.11
Levesque, L.12
Yu, H.13
Yang, D.-S.14
Holmes, E.15
Milman, P.16
Zhang, D.M.17
Xu, D.H.18
Sato, C.19
Rogaev, E.20
Smith, M.21
Janus, C.22
Zhang, Y.23
Aebersold, R.24
Farrer, L.25
Sorbi, S.26
Bruni, A.27
Fraser, P.28
St. George-Hyslop, P.29
more..
-
2
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familiar Alzheimer's disease
-
(1991)
Nature (London)
, vol.349
, pp. 704-706
-
-
Goate, A.M.1
Chartier-Harlin, M.C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
Giuffra, L.7
Haynes, A.8
Irving, N.9
James, L.10
Mant, R.11
Newton, P.12
Rooke, K.13
Roques, P.14
Taebot, C.15
Pericak-Vance, M.16
Roses, A.17
Williamson, R.18
Rossor, M.19
Owen, M.20
Hardy, J.21
more..
-
3
-
-
0029004341
-
Cloning of a gene bearing missense mutation in early onset familial Alzheimer's disease
-
(1995)
Nature (London)
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, C.8
Li, G.9
Holman, K.10
Tsuda, T.11
Mar, L.12
Foncin, J.F.13
Bruni, A.C.14
Montesi, M.P.15
Sorbi, S.16
Rainero, I.17
Pinessi, L.18
Nee, L.19
Chumacov, I.20
Pollen, D.21
Brookes, A.22
Sanseau, P.23
Polinski, R.J.24
Wasco, W.25
Da Silva, H.A.R.26
Haines, J.L.27
Pericak-Vance, M.A.28
Tanzi, R.E.29
Roses, A.D.30
Fraser, P.E.31
Rommans, J.M.32
St. George-Hyslop, P.H.33
more..
-
5
-
-
0027194791
-
Gene dose apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
-
(1993)
Science
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
Sounders, A.M.2
Strittmatter, W.J.3
Schmechel, D.E.4
Gaskell, P.C.5
Small, G.W.6
Roses, A.D.7
Haines, J.L.8
Pericak-Vance, M.A.9
-
7
-
-
0029052710
-
Familial Alzheimer's chromosome 14 mutations
-
(1995)
Nat. Med.
, vol.1
, pp. 848
-
-
Wasco, W.1
Pettingell, W.P.2
Jondro, P.D.3
Schmidt, S.D.4
Gurubhagavatula, S.5
Rodes, L.6
DiBlasi, T.7
Romano, D.M.8
Guenette, S.Y.9
Kovacs, D.M.10
Growdon, J.H.11
Tanzi, R.E.12
-
8
-
-
0029554875
-
A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene
-
(1995)
NeuroReport
, vol.7
, pp. 297-301
-
-
Peret-Tur, J.1
Froelich, S.2
Prihar, G.3
Crook, R.4
Baker, M.5
Duff, K.6
Wragg, M.7
Busfield, F.8
Lendon, C.9
Clark, R.F.10
Roques, P.11
Fuldner, R.A.12
Johnson, J.13
Cowburn, R.14
Forcell, C.15
Axelman, K.16
Lilius, L.17
Houlden, H.18
Karran, E.19
Robert, G.W.20
Rossor, M.21
Adams, M.D.22
Hardy, J.23
Goate, A.24
Lannfelt, L.25
Hutton, M.26
more..
-
9
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
Romano, D.M.4
Oshima, J.5
Pettingell, W.H.6
Yu, C.-E.7
Jondro, P.D.8
Schmidt, S.D.9
Wang, K.10
Crowley, A.C.11
Wu, Y.-H.12
Guenette, S.Y.13
Galas, D.14
Nemens, E.15
Wijsman, E.M.16
Bird, T.D.17
Schellenberg, G.D.18
Tanzi, R.E.19
-
10
-
-
13344282063
-
Alzheimer-associated presenilin 1 and 2: Neuronal expression in brain and localization to intracellular membrane in mammalian cells
-
(1996)
Nat. Med.
, vol.2
, pp. 224-229
-
-
Kovacs, D.M.1
Fausett, H.J.2
Page, K.J.3
Kim, T.W.4
Moir, R.D.5
Merriam, D.E.6
Hollister, R.D.7
Hallmark, O.G.8
Mancini, R.9
Felsentein, K.M.10
Hyman, B.T.11
Tanzi, R.E.12
Wasco, W.13
-
11
-
-
0029812077
-
Expression and analysis of presenilin 1 in a human neuronal system: Localization in cell bodies and dendrites
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 9223-9228
-
-
Cook, D.S.1
Sung, J.C.2
Golde, T.E.3
Felsenstein, K.M.4
Wojczyk, B.S.5
Tanzi, R.E.6
Trojanoski, J.Q.7
Lee, V.M.Y.8
Dorns, R.W.9
-
12
-
-
8044231311
-
The Alzheimer's disease-associated presenilins are differentially within the endoplasmic reticulum
-
(1996)
Mol. Med.
, vol.2
, pp. 673-691
-
-
Walter, J.1
Capel, A.2
Grunberg, J.3
Pesold, B.4
Svlrindzielorz, A.5
Prioe, R.6
Podlisny, M.B.7
Fraser, P.S.8
George-Hslop, P.9
Selkeo, D.J.10
Haass, C.11
-
13
-
-
0030771534
-
Increase apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N14II)
-
(1997)
J. Cell Biol.
, vol.139
, pp. 485-495
-
-
Janicki, S.1
Monteiro, M.J.2
-
16
-
-
0030873546
-
Presenilins are processed by caspase-type proteases
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 20655-20659
-
-
Letscher, H.1
Deuschle, U.2
Brockhaus, M.3
Reinhardt, D.4
Nelboeck, P.5
Mous, J.6
Grunberg, J.7
Haass, C.8
Jacobson, H.9
-
19
-
-
0034621824
-
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
-
(2000)
Nature (London)
, vol.405
, pp. 685-694
-
-
Li, Y.M.1
Xu, M.2
Lai, M.T.3
Huang, Q.4
Castro, J.L.5
DiMuzioMower, J.6
Harrison, T.7
Lellis, C.8
Nadin, A.9
Neduvelil, J.G.10
Register, R.B.11
Sardana, M.K.12
Shearman, M.S.13
Smith, A.L.14
Shi, X.P.15
Yin, K.C.16
Shafer, J.A.17
Gardell, S.J.18
-
21
-
-
0013615899
-
RAGE and amyloid-β-peptide neurotoxicity in Alzheimer's disease
-
(1996)
Nature (London)
, vol.382
, pp. 685-691
-
-
Yan, S.D.1
Chen, X.2
Fu, J.3
Chen, M.4
Zhu, H.5
Roher, A.6
Slattery, T.7
Zhao, L.8
Nagashima, M.9
Morser, J.10
Migheli, A.11
Nawroth, P.12
Stern, D.13
Schmidt, A.M.14
-
24
-
-
0033064547
-
Identification of caspases that cleave presenilin-1 and presenilin-2-five presenilin-1 mutation do not alter the sensitivity of PS1 to caspases
-
(1999)
FEBS Lett.
, vol.445
, pp. 149-154
-
-
Van de Craen, M.1
De Jonghe, C.2
Van den Brande, I.3
Declercq, W.4
Van Gassen, G.5
Van Criekinge, W.6
Vanderhoeven, I.7
Fiers, W.8
Van Broeckhoeven, C.9
Hendriks, L.10
Vandenabeele, P.11
-
25
-
-
18544411933
-
Mutant preselin 2 transgenic mouse: Effect on an age-dependent increase of amyloid β-protein 42 in the brain
-
(1999)
J. Neurochem.
, vol.71
, pp. 313-322
-
-
Oyana, F.1
Sawamura, N.2
Kobayashi, K.3
Morishima-Kawashima, M.4
Kuramuchi, T.5
Ito, M.6
Tomita, T.7
Maruyama, K.8
Saido, T.C.9
Iwatsubo, T.10
Capell, A.11
Walter, J.12
Grunberg, J.13
Ueyama, Y.14
Haass, C.15
Ihara, Y.16
-
26
-
-
0034623284
-
Mutant presenilin 2 transgenic mice. A large increase in the levels of Aβ-42 presumably associated with the low density membrane domain that contains decreased levels of glycero-phospholipids and sphingomyelin
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 27901-27908
-
-
Sawamura, N.1
Morishima-Kawashima, M.2
Waki, H.3
Kobayashi, K.4
Kuramochi, T.5
Frosch, M.P.6
Ding, K.7
Ito, M.8
Kim, T.W.9
Tanzi, R.E.10
Oyama, F.11
Tabita, T.12
Ando, S.13
Ihara, Y.14
-
28
-
-
0009404201
-
Differences in the pattern of hippocampal neuron loss in normal ageing and Alzheimer's disease
-
(1994)
Lancet
, vol.344
, pp. 526-535
-
-
West, M.J.1
-
30
-
-
0033617402
-
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-β precursor protein and amyloidogenic Aβ peptide formation
-
(1999)
Cell
, vol.97
, pp. 395-406
-
-
Gervais, F.G.1
Xu, D.2
Robertson, G.S.3
Vaillancourt, J.P.4
Zhu, Y.5
Huang, J.Q.6
Leblanc, A.7
Smith, D.8
Rigby, M.9
Shearman, M.S.10
Clarke, E.E.11
Zheng, H.12
Van Der Ploeg, L.H.T.13
Ruffolo, S.C.14
Thomberry, N.A.15
Xanthoudakis, S.16
Zamboni, R.J.17
Roy, S.18
Nicolson, D.W.19
-
33
-
-
0030951257
-
Induction of cyclooxygenase-2 in brains of patients with Down's syndrome and dementia of Alzheimer type: Specific localization in affected neurons and axons
-
(1997)
NeuroReport
, vol.8
, pp. 1161-1164
-
-
Oka, A.1
Takashima, S.2
-
34
-
-
12644258498
-
The preselin 2 mutation (N141I) linked to familiar Alzheimer disease (Volga German Families) increases the secretion of amyloid β-protein ending at the 42nd (or 43rd) residue
-
2030
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 2025
-
-
Tomita, T.1
Maruyama, K.2
Saito, T.C.3
Kume, H.4
Shinozaki, K.5
Tokuriro, S.6
Capell, A.7
Walter, J.8
Grunberg, J.9
Haass, C.10
Iwatsubo, T.11
Obata, K.12
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