Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis

Neuroscience

Volumn 91, Issue 3, 1999, Pages 819-830

  Moechars, D ^a   Lorent, K ^a   Van Leuven, F ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Apoptosis; Neurodegeneration; Transgenic mice

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CATHEPSIN D; GLIAL FIBRILLARY ACIDIC PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; RECEPTOR PROTEIN; SYNAPTOPHYSIN; UBIQUITIN;

AGGRESSION; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; ASTROCYTOSIS; BRAIN CORTEX; GENE OVEREXPRESSION; HIPPOCAMPUS; HISTOPATHOLOGY; HYPERSENSITIVITY; LETHAL MUTANT; MOUSE; NEOPHOBIA; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEIZURE; TRANSGENIC MOUSE;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; APOPTOSIS; BRAIN; CATHEPSIN D; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LDL-RECEPTOR RELATED PROTEINS; LONGEVITY; MICE; MICE, TRANSGENIC; MUTATION; NERVE DEGENERATION; NERVE TISSUE PROTEINS; RECEPTORS, GLUTAMATE; RECEPTORS, LDL; RNA, MESSENGER; TISSUE DISTRIBUTION; UBIQUITINS;

EID: 0032953541     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00599-5     Document Type: Article

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