Neuronal Deficiency of Presenilin 1 Inhibits Amyloid Plaque Formation and Corrects Hippocampal Long-Term Potentiation but Not a Cognitive Defect of Amyloid Precursor Protein [V7171] Transgenic Mice

Journal of Neuroscience

Volumn 22, Issue 9, 2002, Pages 3445-3453

  Dewachter, Ilse ^a   Reversé, Delphine ^b   Caluwaerts, Nathalie ^a   Ris, Laurence ^b   Kuipéri, Cuno ^a   Van Den Haute, Chris ^a   Spittaels, Kurt ^a   Umans, Lieve ^a   Serneels, Lutgarde ^a   Thiry, Els ^a   Moechars, Dieder ^c   Mercken, Mark ^c   Godaux, Emile ^b   Van Leuven, Fred ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF MONS   (Belgium)

^c JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

Alzheimer's disease; Amyloid pathology; Cognition; Mouse model; Neuronal plasticity; PS1

Indexed keywords

AMYLOID; AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN[V7171]; CRE RECOMBINASE; GAMMA SECRETASE; PRESENILIN 1; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; HES5 PROTEIN, MOUSE; MEMBRANE PROTEIN; MESSENGER RNA; PEPTIDE FRAGMENT; PROTEIN; PROTEINASE; REPRESSOR PROTEIN; SECRETASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CARBOXY TERMINAL SEQUENCE; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME ACTIVITY; GENE DELETION; HIPPOCAMPUS; LONG TERM POTENTIATION; MORPHOLOGY; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SENILE PLAQUE; TRANSGENIC MOUSE; ANIMAL; CROSS BREEDING; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; ELECTROSTIMULATION; GENETICS; HISTOLOGY; IN VITRO STUDY; METABOLISM; MOUSE MUTANT; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; PHYSIOLOGY; RECOGNITION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRAIN; COGNITION DISORDERS; CROSSES, GENETIC; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; ELECTRIC STIMULATION; ENDOPEPTIDASES; HIPPOCAMPUS; LONG-TERM POTENTIATION; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NEURONAL PLASTICITY; NEURONS; PEPTIDE FRAGMENTS; PHENOTYPE; PRESENILIN-1; RECOGNITION (PSYCHOLOGY); REPRESSOR PROTEINS; RNA, MESSENGER; SENILE PLAQUES;

EID: 0036582717     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-09-03445.2002     Document Type: Article

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