Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes

Brain Research

Volumn 891, Issue 1-2, 2001, Pages 42-53

  Arendash, Gary W ^a   King, David L ^a   Gordon, Marcia N ^a   Morgan, Dave ^a   Hatcher, Jaime M ^a   Hope, Caroline E ^a   Diamond, David M ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Alzheimer's desease; Cognitive performance; Presenillin 1; Sensorimotor function; Transgenic mice, Amyloid precursor protein

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; GENE MUTATION; HIPPOCAMPUS; MAZE TEST; NEOCORTEX; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION; TASK PERFORMANCE; TRANSGENIC MOUSE;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BEHAVIOR, ANIMAL; COGNITION DISORDERS; FEMALE; MALE; MAZE LEARNING; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MOVEMENT DISORDERS; MUSCULOSKELETAL EQUILIBRIUM; MUTATION; PRESENILIN-1; PSYCHOMOTOR PERFORMANCE;

EID: 0035830686     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)03186-3     Document Type: Article

References (32)

1. Dissociation of disinhibitory effects of scopolamine: Stain and task factors
2. Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat
3. Spatial memory deficit in senescent rats
4. Acetyl-1-carnitine: Effects on learning and memory performance of aged rats in simple and complex mazes
5. Familial Alzheimer's disease-linked presenilin 1 variants elevate A-beta 1-42/1-40 ratio in vitro and in vivo
6. Release of excess amyloid beta protein from a mutant amyloid beta protein precursor
7. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
8. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
9. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
10. A behavioural analysis of rats with damage to the medial prefrontal cortex using the Morris water maze: Evidence for behavioral flexibility, but not for impaired spatial navigation
11. Exposing rats to a predator impairs spatial working memory in the radial arm water maze
12. Behavioral disturbances in transgenic mice overexpressing the V717F β-amyloid precursor protein
13. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
14. Microglial response to amyloid plaques in APPsw transgenic mice
15. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
16. Progression of neuropathology in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations
17. Amyloid pathology in 16-month-old mAPP/mPS1 doubly transgenic mice is correlated with deficits in spatial learning and memory
18. Amyloid, the presenilins and Alzheimer's disease
19. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precurson protein and presenilin 1 transgenes
20. Behavioral changes in transgenic mice expressing both amyloid precurson protein and presenilin-1 mutations: Lack of association with amyloid deposits
21. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
22. Water version of the radial-arm maze: Learning in three inbred strains of mice
23. APPsw transgenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1
24. Progressive and gender-dependent cognitive impairment in the APPsw transgenic mouse model for Alzheimer's disease
25. Blind rats are not profoundly impaired in the reference memory Morris water maze and cannot be clearly discriminated from rats with cognitive deficits in the cued platform task
26. Lack of β-amyloidosis in transgenic mice expressing low levels of familial Alzheimer's disease missense mutations
27. Effects of scopolamine, D-amphetamine, and apomorphine on alternation and position biases
28. The radial arm maze as a tool in behavioral pharmacology
29. Adaptation of the circular platform spatial memory task for mice: Use in detecting cognitive impairment in the APPsw transgenic mouse model for Alzheimer's disease
30. Mutant genes in familial Alzheimer's disease and transgenic models
31. Levels and alternative splicing of amyloid β protein precurson (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease
32. The PDAPP transgenic mouse as an animal model for Aβ-induced amyloidosis and neuropathology