-
1
-
-
0029794132
-
A decade of molecular biology of retinoic acid receptors
-
Chambon P. 1996. A decade of molecular biology of retinoic acid receptors. FASEB J. 10:940-54
-
(1996)
FASEB J.
, vol.10
, pp. 940-954
-
-
Chambon, P.1
-
2
-
-
0029562554
-
The RXR heterodimers and orphan receptors
-
Mangelsdorf DJ, Evans RM. 1995. The RXR heterodimers and orphan receptors. Cell 83:841-50
-
(1995)
Cell
, vol.83
, pp. 841-850
-
-
Mangelsdorf, D.J.1
Evans, R.M.2
-
4
-
-
0035976638
-
Nuclear receptors and lipid physiology: Opening the X-files
-
Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ. 2001. Nuclear receptors and lipid physiology: opening the X-files. Science 294:1866-70
-
(2001)
Science
, vol.294
, pp. 1866-1870
-
-
Chawla, A.1
Repa, J.J.2
Evans, R.M.3
Mangelsdorf, D.J.4
-
5
-
-
0037014409
-
Elucidation of the molecular mechanism of action of selective estrogen receptor modulators
-
McDonnell DP, Wijayaratne A, Chang CY, Morris JD. 2002. Elucidation of the molecular mechanism of action of selective estrogen receptor modulators. Am. J. Cardiol. 90:35F-43F
-
(2002)
Am. J. Cardiol.
, vol.90
-
-
McDonnell, D.P.1
Wijayaratne, A.2
Chang, C.Y.3
Morris, J.D.4
-
6
-
-
0037154974
-
Combinatorial control of gene expression by nuclear receptors and coregulators
-
McKenna NJ, O'Malley BW. 2002. Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 108:465-74
-
(2002)
Cell
, vol.108
, pp. 465-474
-
-
McKenna, N.J.1
O'Malley, B.W.2
-
7
-
-
0032213219
-
Structure and specificity of nuclear receptor-coactivator interactions
-
Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, et al. 1998. Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev. 12:3343-56
-
(1998)
Genes Dev.
, vol.12
, pp. 3343-3356
-
-
Darimont, B.D.1
Wagner, R.L.2
Apriletti, J.W.3
Stallcup, M.R.4
Kushner, P.J.5
-
8
-
-
0032446607
-
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
-
Shiau AK, Barstad D, Loria PM, Cheng L, Kushner PJ, et al. 1998. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell 95:927-37
-
(1998)
Cell
, vol.95
, pp. 927-937
-
-
Shiau, A.K.1
Barstad, D.2
Loria, P.M.3
Cheng, L.4
Kushner, P.J.5
-
9
-
-
0029938795
-
Activation and repression by nuclear hormone receptors: Hormone modulates an equilibrium between active and repressive states
-
Schulman IG, Juguilon H, Evans RM. 1996. Activation and repression by nuclear hormone receptors: hormone modulates an equilibrium between active and repressive states. Mol. Cell. Biol. 16:3807-13
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 3807-3813
-
-
Schulman, I.G.1
Juguilon, H.2
Evans, R.M.3
-
10
-
-
0029643780
-
Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid
-
Renaud JP, Rochel N, Ruff M, Vivat V, Chambon P, et al. 1995. Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid. Nature 378:681-89
-
(1995)
Nature
, vol.378
, pp. 681-689
-
-
Renaud, J.P.1
Rochel, N.2
Ruff, M.3
Vivat, V.4
Chambon, P.5
-
11
-
-
0033868825
-
Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains
-
Bourguet W, Vivat V, Wurtz JM, Chambon P, Gronemeyer H, Moras D. 2000. Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains. Mol. Cell. 5:289-98
-
(2000)
Mol. Cell
, vol.5
, pp. 289-298
-
-
Bourguet, W.1
Vivat, V.2
Wurtz, J.M.3
Chambon, P.4
Gronemeyer, H.5
Moras, D.6
-
12
-
-
0034991013
-
Ligands specify coactivator nuclear receptor (NR) box affinity for estrogen receptor subtypes
-
Bramlett KS, Wu Y, Burris TP. 2001. Ligands specify coactivator nuclear receptor (NR) box affinity for estrogen receptor subtypes. Mol. Endocrinol. 15:909-22
-
(2001)
Mol. Endocrinol.
, vol.15
, pp. 909-922
-
-
Bramlett, K.S.1
Wu, Y.2
Burris, T.P.3
-
13
-
-
0035849586
-
Structure-function evaluation of ER alpha and beta interplay with SRC family coactivators. ER selective ligands
-
Wong CW, Komm B, Cheskis BJ. 2001. Structure-function evaluation of ER alpha and beta interplay with SRC family coactivators. ER selective ligands. Biochemistry 40:6756-65
-
(2001)
Biochemistry
, vol.40
, pp. 6756-6765
-
-
Wong, C.W.1
Komm, B.2
Cheskis, B.J.3
-
14
-
-
0035968333
-
Differential recruitment of the mammalian mediator subunit TRAP220 by estrogen receptors ERalpha and ERbeta
-
Warnmark A, Almlof T, Leers J, Gustafsson JA, Treuter E. 2001. Differential recruitment of the mammalian mediator subunit TRAP220 by estrogen receptors ERalpha and ERbeta. J. Biol. Chem. 276:23397-404
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 23397-23404
-
-
Warnmark, A.1
Almlof, T.2
Leers, J.3
Gustafsson, J.A.4
Treuter, E.5
-
15
-
-
0037736575
-
Retinoic acid-induced developmental defects are mediated by RARbeta/RXR heterodimers in the pharyngeal endoderm
-
Matt N, Ghyselinck NB, Wendling O, Chambon P, Mark M. 2003. Retinoic acid-induced developmental defects are mediated by RARbeta/RXR heterodimers in the pharyngeal endoderm. Development 130:2083-93
-
(2003)
Development
, vol.130
, pp. 2083-2093
-
-
Matt, N.1
Ghyselinck, N.B.2
Wendling, O.3
Chambon, P.4
Mark, M.5
-
16
-
-
0037453718
-
Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity
-
Wang YX, Lee CH, Tiep S, Yu RT, Ham J, et al. 2003. Peroxisome- proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell 113:159-70
-
(2003)
Cell
, vol.113
, pp. 159-170
-
-
Wang, Y.X.1
Lee, C.H.2
Tiep, S.3
Yu, R.T.4
Ham, J.5
-
17
-
-
0035654437
-
Estrogen receptors and endocrine diseases: Lessons from estrogen receptor knockout mice
-
Mueller SO, Korach KS. 2001. Estrogen receptors and endocrine diseases: lessons from estrogen receptor knockout mice. Curr. Opin. Pharmacol. 1:613-19
-
(2001)
Curr. Opin. Pharmacol.
, vol.1
, pp. 613-619
-
-
Mueller, S.O.1
Korach, K.S.2
-
18
-
-
0029115655
-
9-cis retinoic acid signaling: Changing partners causes some excitement
-
Leblanc BP, Stunnenberg HG. 1995. 9-cis retinoic acid signaling: changing partners causes some excitement. Genes Dev. 9:1811-16
-
(1995)
Genes Dev.
, vol.9
, pp. 1811-1816
-
-
Leblanc, B.P.1
Stunnenberg, H.G.2
-
19
-
-
1842295133
-
Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepressors
-
DiRenzo J, Soderstrom M, Kurokawa R, Ogliastro MH, Ricote M, et al. 1997. Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepressors. Mol. Cell. Biol. 17:2166-76
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 2166-2176
-
-
DiRenzo, J.1
Soderstrom, M.2
Kurokawa, R.3
Ogliastro, M.H.4
Ricote, M.5
-
20
-
-
0026705751
-
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
-
Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM. 1992. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 358:771-74
-
(1992)
Nature
, vol.358
, pp. 771-774
-
-
Kliewer, S.A.1
Umesono, K.2
Noonan, D.J.3
Heyman, R.A.4
Evans, R.M.5
-
21
-
-
0035933797
-
Role of retinoid receptor coactivator pockets in cofactor recruitment and transcriptional regulation
-
Leo C, Yang X, Liu J, Li H, Chen JD. 2001. Role of retinoid receptor coactivator pockets in cofactor recruitment and transcriptional regulation. J. Biol. Chem. 276:23127-34
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 23127-23134
-
-
Leo, C.1
Yang, X.2
Liu, J.3
Li, H.4
Chen, J.D.5
-
22
-
-
0028811341
-
Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand
-
Roy B, Taneja R, Chambon P. 1995. Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand. Mol. Cell Biol. 15:6481-87
-
(1995)
Mol. Cell Biol.
, vol.15
, pp. 6481-6487
-
-
Roy, B.1
Taneja, R.2
Chambon, P.3
-
23
-
-
0029740183
-
Activation of specific RXR heterodimers by an antagonist of RXR homodimers
-
Lala DS, Mukherjee R, Schulman IG, Koch SS, Dardashti LJ, et al. 1996. Activation of specific RXR heterodimers by an antagonist of RXR homodimers. Nature 383:450-53
-
(1996)
Nature
, vol.383
, pp. 450-453
-
-
Lala, D.S.1
Mukherjee, R.2
Schulman, I.G.3
Koch, S.S.4
Dardashti, L.J.5
-
24
-
-
0031043055
-
The phantom ligand effect: Allosteric control of transcription by the retinoid X receptor
-
Schulman IG, Li C, Schwabe JW, Evans RM. 1997. The phantom ligand effect: allosteric control of transcription by the retinoid X receptor. Genes Dev. 11:299-308
-
(1997)
Genes Dev.
, vol.11
, pp. 299-308
-
-
Schulman, I.G.1
Li, C.2
Schwabe, J.W.3
Evans, R.M.4
-
25
-
-
1442351143
-
Coregulator function: A key to understanding tissue specificity of selective receptor modulators
-
Smith CL, O'Malley BW. 2004. Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocr. Rev. 25:45-71
-
(2004)
Endocr. Rev.
, vol.25
, pp. 45-71
-
-
Smith, C.L.1
O'Malley, B.W.2
-
26
-
-
0026685685
-
The strategic use of antiestrogens to control the development and growth of breast cancer
-
Jordan VC. 1992. The strategic use of antiestrogens to control the development and growth of breast cancer. Cancer 70:977-82
-
(1992)
Cancer
, vol.70
, pp. 977-982
-
-
Jordan, V.C.1
-
27
-
-
0026766517
-
Gynecologic complications associated with long-term adjuvant tamoxifen therapy for breast cancer
-
Wolf DM, Jordan VC. 1992. Gynecologic complications associated with long-term adjuvant tamoxifen therapy for breast cancer. Gynecol. Oncol. 45:118-28
-
(1992)
Gynecol. Oncol.
, vol.45
, pp. 118-128
-
-
Wolf, D.M.1
Jordan, V.C.2
-
28
-
-
0026585852
-
Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer
-
Love RR, Mazess RB, Barden HS, Epstein S, Newcomb PA, et al. 1992. Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer. N. Engl. J. Med. 326:852-56
-
(1992)
N. Engl. J. Med.
, vol.326
, pp. 852-856
-
-
Love, R.R.1
Mazess, R.B.2
Barden, H.S.3
Epstein, S.4
Newcomb, P.A.5
-
29
-
-
0025062215
-
Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen
-
Berry M, Metzger D, Chambon P. 1990. Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen. EMBO J. 9:2811-18
-
(1990)
EMBO J.
, vol.9
, pp. 2811-2818
-
-
Berry, M.1
Metzger, D.2
Chambon, P.3
-
30
-
-
0029796605
-
Different regions in activation function-1 of the human estrogen receptor required for antiestrogen- and estradiol-dependent transcription activation
-
McInerney EM, Katzenellenbogen BS. 1996. Different regions in activation function-1 of the human estrogen receptor required for antiestrogen- and estradiol-dependent transcription activation. J. Biol. Chem. 271:24172-78
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 24172-24178
-
-
McInerney, E.M.1
Katzenellenbogen, B.S.2
-
31
-
-
84995870933
-
Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions
-
Tzukerman MT, Esty A, Santiso-Mere D, Danielian P, Parker MG, et al. 1994. Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. Mol. Endocrinol. 8:21-30
-
(1994)
Mol. Endocrinol.
, vol.8
, pp. 21-30
-
-
Tzukerman, M.T.1
Esty, A.2
Santiso-Mere, D.3
Danielian, P.4
Parker, M.G.5
-
32
-
-
0030664688
-
Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women
-
Delmas PD, Bjarnason NH, Mitlak BH, Ravoux AC, Shah AS, et al. 1997. Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women. N. Engl. J. Med. 337:1641-47
-
(1997)
N. Engl. J. Med.
, vol.337
, pp. 1641-1647
-
-
Delmas, P.D.1
Bjarnason, N.H.2
Mitlak, B.H.3
Ravoux, A.C.4
Shah, A.S.5
-
33
-
-
0030946198
-
Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen 4-hydroxytamoxifen
-
Smith CL, Nawaz Z, O'Malley BW. 1997. Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen 4-hydroxytamoxifen. Mol. Endocrinol. 11:657-66
-
(1997)
Mol. Endocrinol.
, vol.11
, pp. 657-666
-
-
Smith, C.L.1
Nawaz, Z.2
O'Malley, B.W.3
-
34
-
-
0037470031
-
Differential SERM effects on corepressor binding dictate ERalpha activity in vivo
-
Webb P, Nguyen P, Kushner PJ. 2003. Differential SERM effects on corepressor binding dictate ERalpha activity in vivo. J. Biol. Chem. 278:6912-20
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 6912-6920
-
-
Webb, P.1
Nguyen, P.2
Kushner, P.J.3
-
35
-
-
0037062484
-
Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486
-
Liu Z, Auboeuf D, Wong J, Chen JD, Tsai SY, et al. 2002. Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486. Proc. Natl. Acad. Sci. USA 99:7940-44
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 7940-7944
-
-
Liu, Z.1
Auboeuf, D.2
Wong, J.3
Chen, J.D.4
Tsai, S.Y.5
-
36
-
-
0037192501
-
Molecular determinants for the tissue specificity of SERMs
-
Shang Y, Brown M. 2002. Molecular determinants for the tissue specificity of SERMs. Science 295:2465-68
-
(2002)
Science
, vol.295
, pp. 2465-2468
-
-
Shang, Y.1
Brown, M.2
-
37
-
-
11744282298
-
Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes
-
Lavinsky RM, Jepsen K, Heinzel T, Torchia J, Mullen TM, et al. 1998. Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes. Proc. Natl. Acad. Sci. USA 95:2920-25
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 2920-2925
-
-
Lavinsky, R.M.1
Jepsen, K.2
Heinzel, T.3
Torchia, J.4
Mullen, T.M.5
-
38
-
-
0038265311
-
The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism
-
Kauppi B, Jakob C, Farnegardh M, Yang J, Ahola H, et al. 2003. The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism. J. Biol. Chem. 278:22748-54
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 22748-22754
-
-
Kauppi, B.1
Jakob, C.2
Farnegardh, M.3
Yang, J.4
Ahola, H.5
-
39
-
-
0037028042
-
A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta
-
Henke BR, Consler TG, Go N, Hale RL, Hohman DR, et al. 2002. A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta. J. Med. Chem. 45:5492-505
-
(2002)
J. Med. Chem.
, vol.45
, pp. 5492-5505
-
-
Henke, B.R.1
Consler, T.G.2
Go, N.3
Hale, R.L.4
Hohman, D.R.5
-
40
-
-
17544398986
-
Mechanism of corepressor binding and release from nuclear hormone receptors
-
Nagy L, Kao HY, Love JD, Li C, Banayo E, et al. 1999. Mechanism of corepressor binding and release from nuclear hormone receptors. Genes Dev. 13:3209-16
-
(1999)
Genes Dev.
, vol.13
, pp. 3209-3216
-
-
Nagy, L.1
Kao, H.Y.2
Love, J.D.3
Li, C.4
Banayo, E.5
-
41
-
-
0036159939
-
TR surfaces and conformations required to bind nuclear receptor corepressor
-
Marimuthu A, Feng W, Tagami T, Nguyen H, Jameson JL, et al. 2002. TR surfaces and conformations required to bind nuclear receptor corepressor. Mol. Endocrinol. 16:271-86
-
(2002)
Mol. Endocrinol.
, vol.16
, pp. 271-286
-
-
Marimuthu, A.1
Feng, W.2
Tagami, T.3
Nguyen, H.4
Jameson, J.L.5
-
42
-
-
0033572656
-
Molecular determinants of nuclear receptor-corepressor interaction
-
Perissi V, Staszewski LM, McInerney EM, Kurokawa R, Krones A, et al. 1999. Molecular determinants of nuclear receptor-corepressor interaction. Genes Dev. 13:3198-208
-
(1999)
Genes Dev.
, vol.13
, pp. 3198-3208
-
-
Perissi, V.1
Staszewski, L.M.2
McInerney, E.M.3
Kurokawa, R.4
Krones, A.5
-
43
-
-
0033523917
-
The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
-
Hu X, Lazar MA. 1999. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors. Nature 402:93-96
-
(1999)
Nature
, vol.402
, pp. 93-96
-
-
Hu, X.1
Lazar, M.A.2
-
44
-
-
0032807750
-
A novel role for helix 12 of retinoid X receptor in regulating repression
-
Zhang J, Hu X, Lazar MA. 1999. A novel role for helix 12 of retinoid X receptor in regulating repression. Mol. Cell. Biol. 19:6448-57
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 6448-6457
-
-
Zhang, J.1
Hu, X.2
Lazar, M.A.3
-
45
-
-
0035813142
-
Agonist-dependent repression mediated by mutant estrogen receptor alpha that lacks the activation function 2 core domain
-
Jung DJ, Lee SK, Lee JW. 2001. Agonist-dependent repression mediated by mutant estrogen receptor alpha that lacks the activation function 2 core domain. J. Biol. Chem. 276:37280-83
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37280-37283
-
-
Jung, D.J.1
Lee, S.K.2
Lee, J.W.3
-
46
-
-
0030988565
-
Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors
-
Yoh SM, Chatterjee VK, Privalsky ML. 1997. Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors. Mol. Endocrinol. 11:470-80
-
(1997)
Mol. Endocrinol.
, vol.11
, pp. 470-480
-
-
Yoh, S.M.1
Chatterjee, V.K.2
Privalsky, M.L.3
-
47
-
-
0034007387
-
A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesis
-
Gurnell M, Wentworth JM, Agostini M, Adams M, Collingwood TN, et al. 2000. A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesis. J. Biol. Chem. 275:5754-59
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 5754-5759
-
-
Gurnell, M.1
Wentworth, J.M.2
Agostini, M.3
Adams, M.4
Collingwood, T.N.5
-
48
-
-
18244393501
-
Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha
-
Xu HE, Stanley TB, Montana VG, Lambert MH, Shearer BG, et al. 2002. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature 415:813-17
-
(2002)
Nature
, vol.415
, pp. 813-817
-
-
Xu, H.E.1
Stanley, T.B.2
Montana, V.G.3
Lambert, M.H.4
Shearer, B.G.5
-
49
-
-
0038752647
-
Structural basis for bile acid binding and activation of the nuclear receptor FXR
-
Mi LZ, Devarakonda S, Harp JM, Han Q, Pellicciari R, et al. 2003. Structural basis for bile acid binding and activation of the nuclear receptor FXR. Mol. Cell 11:1093-100
-
(2003)
Mol. Cell
, vol.11
, pp. 1093-1100
-
-
Mi, L.Z.1
Devarakonda, S.2
Harp, J.M.3
Han, Q.4
Pellicciari, R.5
-
50
-
-
0038298927
-
Nuclear receptor ligands and cofactor recruitment: Is there a coactivator "on deck"?
-
Nettles KW, Greene GL. 2003. Nuclear receptor ligands and cofactor recruitment: is there a coactivator "on deck"? Mol. Cell. 11:850-51
-
(2003)
Mol. Cell
, vol.11
, pp. 850-851
-
-
Nettles, K.W.1
Greene, G.L.2
-
51
-
-
0030667676
-
Molecular basis of agonism and antagonism in the oestrogen receptor
-
Brzozowski AM, Pike AC, Dauter Z, Hubbard RE, Bonn T, et al. 1997. Molecular basis of agonism and antagonism in the oestrogen receptor. Nature 389:753-58
-
(1997)
Nature
, vol.389
, pp. 753-758
-
-
Brzozowski, A.M.1
Pike, A.C.2
Dauter, Z.3
Hubbard, R.E.4
Bonn, T.5
-
52
-
-
0035099225
-
Structural insights into the mode of action of a pure antiestrogen
-
Pike AC, Brzozowski AM, Walton J, Hubhard RE, Thorsell AG, et al. 2001. Structural insights into the mode of action of a pure antiestrogen. Structure 9:145-53
-
(2001)
Structure
, vol.9
, pp. 145-153
-
-
Pike, A.C.1
Brzozowski, A.M.2
Walton, J.3
Hubhard, R.E.4
Thorsell, A.G.5
-
53
-
-
2642593030
-
The key to the antiestrogenic mechanism of raloxifene is amino acid 351 (aspartate) in the estrogen receptor
-
Levenson AS, Jordan VC. 1998. The key to the antiestrogenic mechanism of raloxifene is amino acid 351 (aspartate) in the estrogen receptor. Cancer Res. 58:1872-75
-
(1998)
Cancer Res.
, vol.58
, pp. 1872-1875
-
-
Levenson, A.S.1
Jordan, V.C.2
-
54
-
-
0035929585
-
The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators
-
Wijayaratne AL, McDonnell DP. 2001. The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. J. Biol. Chem. 276:35684-92
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 35684-35692
-
-
Wijayaratne, A.L.1
McDonnell, D.P.2
-
55
-
-
0037317303
-
A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease
-
Kallenberger BC, Love JD, Chatterjee VK, Schwabe JW. 2003. A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease. Nat. Struct. Biol. 10:136-40
-
(2003)
Nat. Struct. Biol.
, vol.10
, pp. 136-140
-
-
Kallenberger, B.C.1
Love, J.D.2
Chatterjee, V.K.3
Schwabe, J.W.4
-
56
-
-
0036234964
-
Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism
-
Shiau AK, Barstad D, Radek JT, Meyers MJ, Nettles KW, et al. 2002. Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism. Nat. Struct. Biol. 9:359-64
-
(2002)
Nat. Struct. Biol.
, vol.9
, pp. 359-364
-
-
Shiau, A.K.1
Barstad, D.2
Radek, J.T.3
Meyers, M.J.4
Nettles, K.W.5
-
57
-
-
1242294391
-
Allosteric control of ligand selectivity between estrogen receptors alpha and beta: Implications for other nuclear receptors
-
Nettles KW, Sun J, Radek JT, Sheng S, Rodriguez AL, et al. 2004. Allosteric control of ligand selectivity between estrogen receptors alpha and beta: implications for other nuclear receptors. Mol. Cell. 13:317-27
-
(2004)
Mol. Cell
, vol.13
, pp. 317-327
-
-
Nettles, K.W.1
Sun, J.2
Radek, J.T.3
Sheng, S.4
Rodriguez, A.L.5
-
58
-
-
4043176291
-
Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity
-
Greschik H, Flaig R, Renaud JP, Moras D. 2004. Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity. J. Biol. Chem. 279:33639-46
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 33639-33646
-
-
Greschik, H.1
Flaig, R.2
Renaud, J.P.3
Moras, D.4
-
59
-
-
0035431321
-
Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family
-
Cronet P, Petersen JF, Folmer R, Blomberg N, Sjoblom K, et al. 2001. Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family. Structure 9:699-706
-
(2001)
Structure
, vol.9
, pp. 699-706
-
-
Cronet, P.1
Petersen, J.F.2
Folmer, R.3
Blomberg, N.4
Sjoblom, K.5
-
60
-
-
0033105510
-
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
-
Xu HE, Lambert MH, Montana VG, Parks DJ, Blanchard SG, et al. 1999. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol. Cell 3:397-403
-
(1999)
Mol. Cell
, vol.3
, pp. 397-403
-
-
Xu, H.E.1
Lambert, M.H.2
Montana, V.G.3
Parks, D.J.4
Blanchard, S.G.5
-
61
-
-
13044286786
-
A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation
-
Oberfield JL, Collins JL, Holmes CP, Goreham DM, Cooper JP, et al. 1999. A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation. Proc. Natl. Acad. Sci. USA 96:6102-6
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 6102-6106
-
-
Oberfield, J.L.1
Collins, J.L.2
Holmes, C.P.3
Goreham, D.M.4
Cooper, J.P.5
-
62
-
-
0347364651
-
Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor
-
Borngraeber S, Budny MJ, Chiellini G, Cunha-Lima ST, Togashi M, et al. 2003. Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. Proc. Natl. Acad. Sci. USA 100:15358-63
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 15358-15363
-
-
Borngraeber, S.1
Budny, M.J.2
Chiellini, G.3
Cunha-Lima, S.T.4
Togashi, M.5
-
63
-
-
0031813879
-
Transactivation by retinoid X receptor-peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimers: Intermolecular synergy requires only the PPARgamma hormone-dependent activation function
-
Schulman IG, Shao G, Heyman RA. 1998. Transactivation by retinoid X receptor-peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimers: intermolecular synergy requires only the PPARgamma hormone-dependent activation function. Mol. Cell. Biol. 18:3483-94
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 3483-3494
-
-
Schulman, I.G.1
Shao, G.2
Heyman, R.A.3
-
64
-
-
1642304065
-
Structural determinants of allosteric ligand activation in RXR heterodimers
-
Shulman AI, Larson C, Mangelsdorf DJ, Ranganathan R. 2004. Structural determinants of allosteric ligand activation in RXR heterodimers. Cell 116:417-29
-
(2004)
Cell
, vol.116
, pp. 417-429
-
-
Shulman, A.I.1
Larson, C.2
Mangelsdorf, D.J.3
Ranganathan, R.4
-
65
-
-
0030960780
-
Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation
-
Boiling J, Castro DS, Oberg F, Nilsson K, Perlmann T. 1997. Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation. J. Biol. Chem. 272:9443-49
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 9443-9449
-
-
Boiling, J.1
Castro, D.S.2
Oberg, F.3
Nilsson, K.4
Perlmann, T.5
-
66
-
-
0029002298
-
Unique response pathways are established by allosteric interactions among nuclear hormone receptors
-
Forman BM, Umesono K, Chen J, Evans RM. 1995. Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell 81:541-50
-
(1995)
Cell
, vol.81
, pp. 541-550
-
-
Forman, B.M.1
Umesono, K.2
Chen, J.3
Evans, R.M.4
-
67
-
-
0037050017
-
Co-regulator recruitment and the mechanism of retinoic acid receptor synergy
-
Germain P, Iyer J, Zechel C, Gronemeyer H. 2002. Co-regulator recruitment and the mechanism of retinoic acid receptor synergy. Nature 415:187-92
-
(2002)
Nature
, vol.415
, pp. 187-192
-
-
Germain, P.1
Iyer, J.2
Zechel, C.3
Gronemeyer, H.4
-
69
-
-
0030027490
-
3 receptor- and retinoid X receptor-mediated gene activation in vivo
-
3 receptor- and retinoid X receptor-mediated gene activation in vivo. Mol. Cell Biol. 16:1006-16
-
(1996)
Mol. Cell Biol.
, vol.16
, pp. 1006-1016
-
-
Lemon, B.D.1
Freedman, L.P.2
-
70
-
-
0032505066
-
Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators
-
Westin S, Kurokawa R, Nolle RT, Wisely GB, McInerney EM, et al. 1998. Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators. Nature 395:199-202
-
(1998)
Nature
, vol.395
, pp. 199-202
-
-
Westin, S.1
Kurokawa, R.2
Nolle, R.T.3
Wisely, G.B.4
McInerney, E.M.5
-
71
-
-
0029947425
-
Individual subunits of heterodimers comprised of retinoic acid and retinoid X receptors interact with their ligands independently
-
Kersten S, Dawson MI, Lewis BA, Noy N. 1996. Individual subunits of heterodimers comprised of retinoic acid and retinoid X receptors interact with their ligands independently. Biochemistry 35:3816-24
-
(1996)
Biochemistry
, vol.35
, pp. 3816-3824
-
-
Kersten, S.1
Dawson, M.I.2
Lewis, B.A.3
Noy, N.4
-
72
-
-
0034213831
-
Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid
-
Egea PF, Mitschler A, Rochel N, Ruff M, Chambon P, Moras D. 2000. Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid. EMBO J. 19:2592-601
-
(2000)
EMBO J.
, vol.19
, pp. 2592-2601
-
-
Egea, P.F.1
Mitschler, A.2
Rochel, N.3
Ruff, M.4
Chambon, P.5
Moras, D.6
-
73
-
-
0033681001
-
Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors
-
Gampe RT Jr, Montana VG, Lambert MH, Miller AB, Bledsoe RK, et al. 2000. Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. Mol. Cell 5:545-55
-
(2000)
Mol. Cell
, vol.5
, pp. 545-555
-
-
Gampe Jr., R.T.1
Montana, V.G.2
Lambert, M.H.3
Miller, A.B.4
Bledsoe, R.K.5
-
74
-
-
0034612290
-
Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma
-
Klaholz BP, Mitschler A, Belema M, Zusi C, Moras D. 2000. Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma. Proc. Natl. Acad. Sci. USA 97:6322-27
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6322-6327
-
-
Klaholz, B.P.1
Mitschler, A.2
Belema, M.3
Zusi, C.4
Moras, D.5
-
75
-
-
0034622982
-
Structural basis for isotype selectivity of the human retinoic acid nuclear receptor
-
Klaholz BP, Mitschler A, Moras D. 2000. Structural basis for isotype selectivity of the human retinoic acid nuclear receptor. J. Mol. Biol. 302:155-70
-
(2000)
J. Mol. Biol.
, vol.302
, pp. 155-170
-
-
Klaholz, B.P.1
Mitschler, A.2
Moras, D.3
-
76
-
-
0031892525
-
Conformational adaptation of agonists to the human nuclear receptor RAR gamma
-
Klaholz BP, Renaud JP, Mitschler A, Zusi C, Chambon P, et al. 1998. Conformational adaptation of agonists to the human nuclear receptor RAR gamma. Nat. Struct. Biol. 5:199-202
-
(1998)
Nat. Struct. Biol.
, vol.5
, pp. 199-202
-
-
Klaholz, B.P.1
Renaud, J.P.2
Mitschler, A.3
Zusi, C.4
Chambon, P.5
-
77
-
-
0037192817
-
The structural basis for the specificity of retinoid-X receptor-selective agonists: New insights into the role of helix H12
-
Love JD, Gooch JT, Benko S, Li C, Nagy L, et al. 2002. The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12. J. Biol. Chem. 277:11385-91
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 11385-11391
-
-
Love, J.D.1
Gooch, J.T.2
Benko, S.3
Li, C.4
Nagy, L.5
-
78
-
-
0032505096
-
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma
-
Nolle RT, Wisely GB, Westin S, Cobb JE, Lambert MH, et al. 1998. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature 395:137-43
-
(1998)
Nature
, vol.395
, pp. 137-143
-
-
Nolle, R.T.1
Wisely, G.B.2
Westin, S.3
Cobb, J.E.4
Lambert, M.H.5
-
79
-
-
0035923672
-
Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors
-
Xu HE, Lambert MH, Montana VG, Plunket KD, Moore LB, et al. 2001. Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. USA 98:13919-24
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 13919-13924
-
-
Xu, H.E.1
Lambert, M.H.2
Montana, V.G.3
Plunket, K.D.4
Moore, L.B.5
-
80
-
-
0141737105
-
Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation
-
Svensson S, Ostberg T, Jacobsson M, Norstrom C, Stefansson K, et al. 2003. Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation. EMBO J. 22:4625-33
-
(2003)
EMBO J.
, vol.22
, pp. 4625-4633
-
-
Svensson, S.1
Ostberg, T.2
Jacobsson, M.3
Norstrom, C.4
Stefansson, K.5
-
81
-
-
0033777133
-
Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivators
-
Yang W, Rachez C, Freedman LP. 2000. Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivators. Mol. Cell Biol. 20:8008-17
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 8008-8017
-
-
Yang, W.1
Rachez, C.2
Freedman, L.P.3
-
82
-
-
0031038518
-
Retinoid X receptor (RXR) within the RXR-retinoic acid receptor heterodimer binds its ligand and enhances retinoid-dependent gene expression
-
Minucci S, Leid M, Toyama R, Saint-Jeannet JP, Peterson VJ, et al. 1997. Retinoid X receptor (RXR) within the RXR-retinoic acid receptor heterodimer binds its ligand and enhances retinoid-dependent gene expression. Mol. Cell. Biol. 17:644-55
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 644-655
-
-
Minucci, S.1
Leid, M.2
Toyama, R.3
Saint-Jeannet, J.P.4
Peterson, V.J.5
-
83
-
-
0030056997
-
A canonical structure for the ligand-binding domain of nuclear receptors
-
Wurtz JM, Bourguet W, Renaud JP, Vivat V, Chambon P, et al. 1996. A canonical structure for the ligand-binding domain of nuclear receptors. Nat. Struct. Biol. 3:206
-
(1996)
Nat. Struct. Biol.
, vol.3
, pp. 206
-
-
Wurtz, J.M.1
Bourguet, W.2
Renaud, J.P.3
Vivat, V.4
Chambon, P.5
-
85
-
-
0036088602
-
The linkage between protein folding and functional cooperativity: Two sides of the same coin?
-
Luque I, Leavitt SA, Freire E. 2002. The linkage between protein folding and functional cooperativity: two sides of the same coin? Annu. Rev. Biophys. Biomol. Struct. 31:235-56
-
(2002)
Annu. Rev. Biophys. Biomol. Struct.
, vol.31
, pp. 235-256
-
-
Luque, I.1
Leavitt, S.A.2
Freire, E.3
-
86
-
-
0034724560
-
Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: Implications for nuclear receptor activation
-
Johnson BA, Wilson EM, Li Y, Moller DE, Smith RG, Zhou G. 2000. Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation. J. Mol. Biol. 298:187-94
-
(2000)
J. Mol. Biol.
, vol.298
, pp. 187-194
-
-
Johnson, B.A.1
Wilson, E.M.2
Li, Y.3
Moller, D.E.4
Smith, R.G.5
Zhou, G.6
-
88
-
-
0027521287
-
Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain
-
Beekman JM, Allan GF, Tsai SY, Tsai MJ, O'Malley BW. 1993. Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain. Mol. Endocrinol. 7:1266-74
-
(1993)
Mol. Endocrinol.
, vol.7
, pp. 1266-1274
-
-
Beekman, J.M.1
Allan, G.F.2
Tsai, S.Y.3
Tsai, M.J.4
O'Malley, B.W.5
-
89
-
-
0035937246
-
Effects of ligand binding on the association properties and conformation in solution of retinoic acid receptors RXR and RAR
-
Egea PF, Rochel N, Birck C, Vachette P, Timmins PA, Moras D. 2001. Effects of ligand binding on the association properties and conformation in solution of retinoic acid receptors RXR and RAR. J. Mol. Biol. 307:557-76
-
(2001)
J. Mol. Biol.
, vol.307
, pp. 557-576
-
-
Egea, P.F.1
Rochel, N.2
Birck, C.3
Vachette, P.4
Timmins, P.A.5
Moras, D.6
-
90
-
-
0942290634
-
Dynamics and ligand-induced solvent accessibility changes in human retinoid X receptor homodimer determined by hydrogen deuterium exchange and mass spectrometry
-
Yan X, Broderick D, Leid ME, Schimerlik MI, Deinzer ML. 2004. Dynamics and ligand-induced solvent accessibility changes in human retinoid X receptor homodimer determined by hydrogen deuterium exchange and mass spectrometry. Biochemistry 43:909-17
-
(2004)
Biochemistry
, vol.43
, pp. 909-917
-
-
Yan, X.1
Broderick, D.2
Leid, M.E.3
Schimerlik, M.I.4
Deinzer, M.L.5
-
91
-
-
0033305430
-
Coactivator peptides have a differential stabilizing effect on the binding of estrogens and antiestrogens with the estrogen receptor
-
Gee AC, Carlson KE, Martini PG, Katzenellenbogen BS, Katzenellenbogen JA. 1999. Coactivator peptides have a differential stabilizing effect on the binding of estrogens and antiestrogens with the estrogen receptor. Mol. Endocrinol. 13:1912-23
-
(1999)
Mol. Endocrinol.
, vol.13
, pp. 1912-1923
-
-
Gee, A.C.1
Carlson, K.E.2
Martini, P.G.3
Katzenellenbogen, B.S.4
Katzenellenbogen, J.A.5
-
92
-
-
0043168030
-
Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor
-
Watkins RE, Davis-Searles PR, Lambert MH, Redinbo MR. 2003. Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. J. Mol. Biol. 331:815-28
-
(2003)
J. Mol. Biol.
, vol.331
, pp. 815-828
-
-
Watkins, R.E.1
Davis-Searles, P.R.2
Lambert, M.H.3
Redinbo, M.R.4
-
93
-
-
1542329067
-
Molecular determinants of ER alpha and ER beta involved in selectivity of 16 alpha-iodo-7 beta estradiol
-
Bhat RA, Stauffer B, Unwalla RJ, Xu Z, Harris HA, Komm BS. 2004. Molecular determinants of ER alpha and ER beta involved in selectivity of 16 alpha-iodo-7 beta estradiol. J. Steroid. Biochem. Mol. Biol. 88:17-26
-
(2004)
J. Steroid. Biochem. Mol. Biol.
, vol.88
, pp. 17-26
-
-
Bhat, R.A.1
Stauffer, B.2
Unwalla, R.J.3
Xu, Z.4
Harris, H.A.5
Komm, B.S.6
-
94
-
-
0033304499
-
Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1, 1,1-trichloroethane with estrogen receptors alpha and beta
-
Gaido KW, Leonard LS, Maness SC, Hall JM, McDonnell DP, et al. 1999. Differential interaction of the methoxychlor metabolite 2,2-bis-(p- hydroxyphenyl)-1, 1,1-trichloroethane with estrogen receptors alpha and beta. Endocrinology 140:5746-53
-
(1999)
Endocrinology
, vol.140
, pp. 5746-5753
-
-
Gaido, K.W.1
Leonard, L.S.2
Maness, S.C.3
Hall, J.M.4
McDonnell, D.P.5
-
95
-
-
0037312834
-
Molecular basis for the subtype discrimination of the estrogen receptor-beta-selective ligand, diarylpropionitrile
-
Sun J, Baudry J, Katzenellenbogen JA, Katzenellenbogen BS. 2003. Molecular basis for the subtype discrimination of the estrogen receptor-beta-selective ligand, diarylpropionitrile. Mol. Endocrinol. 17:247-58
-
(2003)
Mol. Endocrinol.
, vol.17
, pp. 247-258
-
-
Sun, J.1
Baudry, J.2
Katzenellenbogen, J.A.3
Katzenellenbogen, B.S.4
-
96
-
-
0037379703
-
Mutation of the androgen receptor at amino acid 708 (Gly→Ala) abolishes partial agonist activity of steroidal antiandrogens
-
Terouanne B, Nirde P, Rabenoelina F, Bourguet W, Sultan C, Auzou G. 2003. Mutation of the androgen receptor at amino acid 708 (Gly→Ala) abolishes partial agonist activity of steroidal antiandrogens. Mol. Pharmacol. 63:791-98
-
(2003)
Mol. Pharmacol.
, vol.63
, pp. 791-798
-
-
Terouanne, B.1
Nirde, P.2
Rabenoelina, F.3
Bourguet, W.4
Sultan, C.5
Auzou, G.6
-
97
-
-
0042072797
-
Subtype specific effects of peroxisome proliferator-activated receptor ligands on corepressor affinity
-
Stanley TB, Leesnitzer LM, Montana VG, Galardi CM, Lambert MH, et al. 2003. Subtype specific effects of peroxisome proliferator-activated receptor ligands on corepressor affinity. Biochemistry 42:9278-87
-
(2003)
Biochemistry
, vol.42
, pp. 9278-9287
-
-
Stanley, T.B.1
Leesnitzer, L.M.2
Montana, V.G.3
Galardi, C.M.4
Lambert, M.H.5
-
98
-
-
0344931796
-
Retinoic acid receptor: A simulation analysis of retinoic acid binding and the resulting conformational changes
-
Blondel A, Renaud JP, Fischer S, Moras D, Karplus M. 1999. Retinoic acid receptor: a simulation analysis of retinoic acid binding and the resulting conformational changes. J. Mol. Biol. 291:101-15
-
(1999)
J. Mol. Biol.
, vol.291
, pp. 101-115
-
-
Blondel, A.1
Renaud, J.P.2
Fischer, S.3
Moras, D.4
Karplus, M.5
-
99
-
-
0037384560
-
Isotype-restricted corepressor recruitment: A constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression
-
Farboud B, Hauksdottir H, Wu Y, Privalsky ML. 2003. Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression. Mol. Cell Biol. 23:2844-58
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 2844-2858
-
-
Farboud, B.1
Hauksdottir, H.2
Wu, Y.3
Privalsky, M.L.4
-
100
-
-
0037341724
-
Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand
-
Hauksdottir H, Farboud B, Privalsky ML. 2003. Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand. Mol. Endocrinol. 17:373-85
-
(2003)
Mol. Endocrinol.
, vol.17
, pp. 373-385
-
-
Hauksdottir, H.1
Farboud, B.2
Privalsky, M.L.3
-
101
-
-
0038526314
-
Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors
-
Wang Z, Benoit G, Liu J, Prasad S, Aarnisalo P, et al. 2003. Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature 423:555-60
-
(2003)
Nature
, vol.423
, pp. 555-560
-
-
Wang, Z.1
Benoit, G.2
Liu, J.3
Prasad, S.4
Aarnisalo, P.5
-
102
-
-
0038508965
-
The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway
-
Baker KD, Shewchuk LM, Kozlova T, Makishima M, Hassell A, et al. 2003. The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway. Cell 113:731-42
-
(2003)
Cell
, vol.113
, pp. 731-742
-
-
Baker, K.D.1
Shewchuk, L.M.2
Kozlova, T.3
Makishima, M.4
Hassell, A.5
-
103
-
-
0038503976
-
Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1
-
Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA. 2003. Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1. Mol. Cell 11:1575-85
-
(2003)
Mol. Cell
, vol.11
, pp. 1575-1585
-
-
Sablin, E.P.1
Krylova, I.N.2
Fletterick, R.J.3
Ingraham, H.A.4
-
104
-
-
0036311095
-
A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity
-
Dussault I, Lin M, Hollister K, Fan M, Termini J, et al. 2002. A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity. Mol. Cell Biol. 22:5270-80
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 5270-5280
-
-
Dussault, I.1
Lin, M.2
Hollister, K.3
Fan, M.4
Termini, J.5
-
105
-
-
0032497544
-
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
-
Forman BM, Tzameli I, Choi HS, Chen J, Simha D, et al. 1998. Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. Nature 395:612-15
-
(1998)
Nature
, vol.395
, pp. 612-615
-
-
Forman, B.M.1
Tzameli, I.2
Choi, H.S.3
Chen, J.4
Simha, D.5
-
106
-
-
0344011490
-
Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors
-
Suetsugi M, Su L, Karlsberg K, Yuan YC, Chen S. 2003. Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol. Cancer Res. 1:981-91
-
(2003)
Mol. Cancer Res.
, vol.1
, pp. 981-991
-
-
Suetsugi, M.1
Su, L.2
Karlsberg, K.3
Yuan, Y.C.4
Chen, S.5
-
107
-
-
0033999734
-
The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR
-
Tzameli I, Pissios P, Schuetz EG, Moore DD. 2000. The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol. Cell Biol. 20:2951-58
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 2951-2958
-
-
Tzameli, I.1
Pissios, P.2
Schuetz, E.G.3
Moore, D.D.4
-
108
-
-
0037931737
-
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes
-
Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, et al. 2003. Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J. Biol. Chem. 278:17277-83
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 17277-17283
-
-
Maglich, J.M.1
Parks, D.J.2
Moore, L.B.3
Collins, J.L.4
Goodwin, B.5
-
109
-
-
0037063997
-
Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand
-
Dhe-Paganon S, Duda K, Iwamoto M, Chi YI, Shoelson SE. 2002. Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand. J. Biol. Chem. 277:37973-76
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 37973-37976
-
-
Dhe-Paganon, S.1
Duda, K.2
Iwamoto, M.3
Chi, Y.I.4
Shoelson, S.E.5
-
110
-
-
0036710140
-
Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids
-
Wisely GB, Miller AB, Davis RG, Thornquest AD Jr, Johnson R, et al. 2002. Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. Structure 10:1225-34
-
(2002)
Structure
, vol.10
, pp. 1225-1234
-
-
Wisely, G.B.1
Miller, A.B.2
Davis, R.G.3
Thornquest Jr., A.D.4
Johnson, R.5
-
111
-
-
1842639533
-
Crystal structure of the human RORalpha ligand binding domain in complex with cholesterol sulfate at 2.2 A
-
Kallen J, Schlaeppi JM, Bitsch F, Delhon I, Founder B. 2004. Crystal structure of the human RORalpha ligand binding domain in complex with cholesterol sulfate at 2.2 A. J. Biol. Chem. 279:14033-38
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 14033-14038
-
-
Kallen, J.1
Schlaeppi, J.M.2
Bitsch, F.3
Delhon, I.4
Founder, B.5
-
112
-
-
1842848068
-
X-ray structure of the hRORalpha LBD at 1.63 Å: Structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha
-
Kallen JA, Schlaeppi JM, Bitsch F, Geisse S, Geiser M, et al. 2002. X-ray structure of the hRORalpha LBD at 1.63 Å: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha. Structure 10:1697-707
-
(2002)
Structure
, vol.10
, pp. 1697-1707
-
-
Kallen, J.A.1
Schlaeppi, J.M.2
Bitsch, F.3
Geisse, S.4
Geiser, M.5
-
113
-
-
0037234105
-
In vivo imaging of transcriptionally active estrogen receptors
-
Ciana P, Raviscioni M, Mussi P, Vegeto E, Que I, et al. 2003. In vivo imaging of transcriptionally active estrogen receptors. Nat. Med. 9:82-86
-
(2003)
Nat. Med.
, vol.9
, pp. 82-86
-
-
Ciana, P.1
Raviscioni, M.2
Mussi, P.3
Vegeto, E.4
Que, I.5
-
114
-
-
9144256614
-
Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance
-
Schiff R, Massarweh SA, Shou J, Bharwani L, Mohsin SK, Osborne K. 2004. Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance. Clin. Cancer Res. 10:331S-36S
-
(2004)
Clin. Cancer Res.
, vol.10
-
-
Schiff, R.1
Massarweh, S.A.2
Shou, J.3
Bharwani, L.4
Mohsin, S.K.5
Osborne, K.6
-
115
-
-
0242290172
-
Molecular determinants of the balance between co-repressor and co-activator recruitment to the retinoic acid receptor
-
Benko S, Love JD, Beladi M, Schwabe JW, Nagy L. 2003. Molecular determinants of the balance between co-repressor and co-activator recruitment to the retinoic acid receptor. J. Biol. Chem. 278:43797-806
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 43797-43806
-
-
Benko, S.1
Love, J.D.2
Beladi, M.3
Schwabe, J.W.4
Nagy, L.5
-
116
-
-
0033599038
-
Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension
-
Barroso I, Gurnell M, Crowley VE, Agostini M, Schwabe JW, et al. 1999. Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 402:880-83
-
(1999)
Nature
, vol.402
, pp. 880-883
-
-
Barroso, I.1
Gurnell, M.2
Crowley, V.E.3
Agostini, M.4
Schwabe, J.W.5
-
117
-
-
0030445855
-
Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein
-
Weis KE, Ekena K, Thomas JA, Lazennec G, Katzenellenbogen BS. 1996. Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein. Mol. Endocrinol. 10:1388-98
-
(1996)
Mol. Endocrinol.
, vol.10
, pp. 1388-1398
-
-
Weis, K.E.1
Ekena, K.2
Thomas, J.A.3
Lazennec, G.4
Katzenellenbogen, B.S.5
-
118
-
-
0032541336
-
A role for helix 3 of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone
-
Collingwood TN, Wagner R, Matthews CH, Clifton-Bligh RJ, Gurnell M, et al. 1998. A role for helix 3 of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone. EMBO J. 17:4760-70
-
(1998)
EMBO J.
, vol.17
, pp. 4760-4770
-
-
Collingwood, T.N.1
Wagner, R.2
Matthews, C.H.3
Clifton-Bligh, R.J.4
Gurnell, M.5
-
119
-
-
12144291700
-
Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma
-
Agostini M, Gurnell M, Savage DB, Wood EM, Smith AG, et al. 2004. Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma. Endocrinology 145:1527-38
-
(2004)
Endocrinology
, vol.145
, pp. 1527-1538
-
-
Agostini, M.1
Gurnell, M.2
Savage, D.B.3
Wood, E.M.4
Smith, A.G.5
-
120
-
-
0030734795
-
Altered ligand binding properties and enhanced stability of a constitutively active estrogen receptor: Evidence that an open pocket conformation is required for ligand interaction
-
Carlson KE, Choi I, Gee A, Katzenellenbogen BS, Katzenellenbogen JA. 1997. Altered ligand binding properties and enhanced stability of a constitutively active estrogen receptor: evidence that an open pocket conformation is required for ligand interaction. Biochemistry 36:14897-905
-
(1997)
Biochemistry
, vol.36
, pp. 14897-14905
-
-
Carlson, K.E.1
Choi, I.2
Gee, A.3
Katzenellenbogen, B.S.4
Katzenellenbogen, J.A.5
-
121
-
-
0036020499
-
Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists
-
Huang HJ, Norris JD, McDonnell DP. 2002. Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists. Mol. Endocrinol. 16:1778-92
-
(2002)
Mol. Endocrinol.
, vol.16
, pp. 1778-1792
-
-
Huang, H.J.1
Norris, J.D.2
McDonnell, D.P.3
-
122
-
-
0028093565
-
The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain
-
Wolf DM, Jordan VC. 1994. The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain. Breast Cancer Res. Treat. 31:129-38
-
(1994)
Breast Cancer Res. Treat.
, vol.31
, pp. 129-138
-
-
Wolf, D.M.1
Jordan, V.C.2
-
123
-
-
0035900785
-
The tamoxifen-responsive estrogen receptor alpha mutant D351Y shows reduced tamoxifen-dependent interaction with corepressor complexes
-
Yamamoto Y, Wada O, Suzawa M, Yogiashi Y, Yano T, et al. 2001. The tamoxifen-responsive estrogen receptor alpha mutant D351Y shows reduced tamoxifen-dependent interaction with corepressor complexes. J. Biol. Chem. 276:42684-91
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 42684-42691
-
-
Yamamoto, Y.1
Wada, O.2
Suzawa, M.3
Yogiashi, Y.4
Yano, T.5
-
124
-
-
0344931629
-
The interaction of raloxifene and the active metabolite of the antiestrogen EM-800 (SC 5705) with the human estrogen receptor
-
Schafer JI, Liu H, Tonetti DA, Jordan VC. 1999. The interaction of raloxifene and the active metabolite of the antiestrogen EM-800 (SC 5705) with the human estrogen receptor. Cancer Res. 59:4308-13
-
(1999)
Cancer Res.
, vol.59
, pp. 4308-4313
-
-
Schafer, J.I.1
Liu, H.2
Tonetti, D.A.3
Jordan, V.C.4
-
125
-
-
0031008040
-
Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor
-
Levenson AS, Catherine WH, Jordan VC. 1997. Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor. J. Steroid. Biochem. Mol. Biol. 60:261-68
-
(1997)
J. Steroid. Biochem. Mol. Biol.
, vol.60
, pp. 261-268
-
-
Levenson, A.S.1
Catherine, W.H.2
Jordan, V.C.3
-
126
-
-
0034532014
-
An antiestrogen-responsive estrogen receptor-alpha mutant (D351Y) shows weak AF-2 activity in the presence of tamoxifen
-
Webb P, Nguyen P, Valentine C, Weatherman RV, Scanlan TS, Kushner PJ. 2000. An antiestrogen-responsive estrogen receptor-alpha mutant (D351Y) shows weak AF-2 activity in the presence of tamoxifen. J. Biol. Chem. 275:37552-58
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 37552-37558
-
-
Webb, P.1
Nguyen, P.2
Valentine, C.3
Weatherman, R.V.4
Scanlan, T.S.5
Kushner, P.J.6
-
127
-
-
0034730644
-
Evidence for a common step in three different processes for modulating the kinetic properties of glucocorticoid receptor-induced gene transcription
-
Chen S, Sarlis NJ, Simons SS Jr. 2000. Evidence for a common step in three different processes for modulating the kinetic properties of glucocorticoid receptor-induced gene transcription. J. Biol. Chem. 275:30106-17
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 30106-30117
-
-
Chen, S.1
Sarlis, N.J.2
Simons Jr., S.S.3
-
128
-
-
0028122988
-
Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding
-
Kurokawa R, DiRenzo J, Boehm M, Sugarman J, Gloss B, et al. 1994. Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding. Nature 371:528-31
-
(1994)
Nature
, vol.371
, pp. 528-531
-
-
Kurokawa, R.1
DiRenzo, J.2
Boehm, M.3
Sugarman, J.4
Gloss, B.5
-
129
-
-
0031900850
-
Estrogen response elements function as allosteric modulators of estrogen receptor conformation
-
Wood JR, Greene GL, Nardulli AM. 1998. Estrogen response elements function as allosteric modulators of estrogen receptor conformation. Mol. Cell. Biol. 18:1927-34
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 1927-1934
-
-
Wood, J.R.1
Greene, G.L.2
Nardulli, A.M.3
-
130
-
-
0035976933
-
Estrogen response elements alter coactivator recruitment through allosteric modulation of estrogen receptor beta conformation
-
Loven MA, Likhite VS, Choi I, Nardulli AM. 2001. Estrogen response elements alter coactivator recruitment through allosteric modulation of estrogen receptor beta conformation. J. Biol. Chem. 276:45282-88
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 45282-45288
-
-
Loven, M.A.1
Likhite, V.S.2
Choi, I.3
Nardulli, A.M.4
-
131
-
-
0034680924
-
Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor (ER) alpha and ER beta
-
Routledge EJ, White R, Parker MG, Sumpter JP. 2000. Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor (ER) alpha and ER beta. J. Biol. Chem. 275:35986-93
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 35986-35993
-
-
Routledge, E.J.1
White, R.2
Parker, M.G.3
Sumpter, J.P.4
-
132
-
-
18544390636
-
Ligand and coactivator recruitment preferences of peroxisome proliferator activated receptor alpha
-
Mukherjee R, Sun S, Santomenna L, Miao B, Walton H, et al. 2002. Ligand and coactivator recruitment preferences of peroxisome proliferator activated receptor alpha. J. Steroid Biochem. Mol. Biol. 81:217-25
-
(2002)
J. Steroid Biochem. Mol. Biol.
, vol.81
, pp. 217-225
-
-
Mukherjee, R.1
Sun, S.2
Santomenna, L.3
Miao, B.4
Walton, H.5
|