Activation and repression by nuclear hormone receptors: Hormone modulates an equilibrium between active and repressive states

Molecular and Cellular Biology

Volumn 16, Issue 7, 1996, Pages 3807-3813

  Schulman, Ira G ^a   Juguilon, Henry ^a,b   Evans, Ronald M ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [(5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 NAPHTHYL)CARBOXAMIDO]BENZOIC ACID; ALITRETINOIN; COLECALCIFEROL; HORMONE RECEPTOR; LIOTHYRONINE; RETINOID X RECEPTOR; THYROID HORMONE RECEPTOR;

ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; DNA BINDING; ELECTROPHORETIC MOBILITY; HORMONAL REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; RECEPTOR BINDING; TRANSACTIVATION; TRANSCRIPTION REGULATION;

EID: 0029938795     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.7.3807     Document Type: Article

References (46)

1. Baniahmad, A., I. Ha, D. Reinberg, S. Tsai, M.-J. Tsai, and B. W. O'Malley. 1993. Interaction of human thyroid hormone receptor β with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone. Proc. Natl. Acad. Sci. USA 90:8832-8836.
2. Baniahmad, A., A. C. Kohne, and R. Renkawitz. 1992. A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and the retinoic acid receptor. EMBO J. 11:1015-1023.
3. Baniahmad, A., X. Leng, T. P. Burris, S. V. Tsai, M.-J. Tsai, and B. W. O'Malley. 1995. The 74 activation domain of the thyroid hormone receptor is required for the release of a putative corepressor(s) necessary for transcriptional silencing. Mol. Cell. Biol. 15:76-86.
4. Barettino, D., M. del Mar Vivanco Ruiz, and H. G. Stunnenberg. 1994. Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor. EMBO J. 13:3039-3049.
5. Bourguet, W., M. Ruff, P. Chambon, H. Gronemeyer, and D. Muras. 1995. Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha. Nature (London) 375:377-382.
6. Casanova, J., E. Helmer, S. Selmi-Ruby, J.-S. Qi, M. Au-Fliegner, V. Desai-Yajnik, N. Koudinova, F. Yarm, B. M. Raaka, and H. H. Samuels. 1994. Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoic acid receptors from an inhibitory cellular factor. Mol. Cell. Biol. 14:5756-5765.
7. Chen, J. D., and R. M. Evans. 1995. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature (London) 377:454-457.
8. Chen, J. D., K. Umesono, and R. M. Evans. SMRT isoforms mediate repression and antirepression of nuclear heterodimers. Proc. Natl. Acad. Sci. USA, in press.
9. Damm, K., R. A. Heyman, K. Umesono, and R. A. Evans. 1993. Functional inhibition of retinoic acid response by dominant negative retinoic receptor mutants. Proc. Natl. Acad. Sci. USA 90:2989-2993.
10. Damm, K., C. C. Thompson, and R. M. Evans. 1989. Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist. Nature (London) 339:593-597.
11. Durand, B., M. Saunders, C. Gaudon, B. Roy, R. Losson, and P. Chambon. 1994. Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity. EMBO J. 13:5370-5382.
12. Elble, R. 1992. A simple and efficient procedure for transformation of yeasts. BioTechniques 13:18-20.
13. Flynn, T. R., A. N. Hollenberg, O. Cohen, J. B. Menke, S. J. Usala, S. Tollin, M. K. Hegarty, and F. E. Wondisford. 1994. A novel C-terminal domain in the thyroid hormone receptor selectively mediates thyroid hormone induction. J. Biol. Chem. 269:32713-32716.
14. Fondell, J. D., F. Brunel, K. Hisatake, and R. G. Roeder. 1996. Unliganded thyroid hormone receptor α can target TATA-binding protein for transcriptional repression. Mol. Cell. Biol. 16:281-287.
15. Fondell, J. D., A. L. Roy, and R. G. Roeder. 1993. Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression. Genes Dev. 7:1400-1410.
16. Forman, B. M., K. Umesono, J. Chen, and R. M. Evans. 1995. Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell 81:541-550.
17. Hall, B. L., Z. Smit-McBride, and M. Privalsky. 1993. Reconstitution of retinoid X receptor function and combinatorial regulation of other nuclear hormone receptors in the yeast Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 90:6929-6933.
18. Harding, H. P., and M. A. Lazar. 1995. The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat. Mol. Cell. Biol. 15:4791-4802.
19. Herry, D. M., B. Pierrat, H. Gronemeyer, P. Chambon, and R. Losson. 1994. Homo- and heterodimers of the retinoid X receptor (RXR) activate transcription in yeast. Nucleic Acids Res. 22:726-731.
20. Hollenberg, A. N., T. Monden, and K. E. Wondisford. 1995. Ligand-independent and -dependent functions of thyroid hormone receptor isoforms depend upon their distinct amino termini. J. Biol. Chem. 270:14274-14280.
21. Hörlein, A. J., A. M. Naar, T. Heinzel, J. Torchia, B. Gloss, R. Kurokawa, A. Ryan, Y. Kamai, M. Soderstrom, C. K. Glass, and M. G. Rosenfeld. 1995. Hormone-independent repression by the thyroid hormone receptor is mediated by a nuclear receptor co-repressor N-COR. Nature (London) 377:397-404.
22. Kastner, P., M. Mark, and P. Chambon. 1995. Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell 83:859-869.
23. Kurokawa, R., M. Soderstrom, A. Horlein, S. Halachmi, M. Brown, M. G. Rosenfeld, and C. K. Glass. 1995. A co-repressor specifics polarity-specific activities of retinoic acid receptors. Nature (London) 377:451-457.
24. Leblanc, B. P., and H. G. Stunnenberg. 1995. 9-cis retinoic acid signaling: changing partners causes some excitement. Genes Dev. 9:1811-1816.
25. Lee, J. W., D. D. Moore, and R. A. Heyman 1994. A chimeric thyroid hormone receptor constitutively bound In DNA requires retinoid X receptor for hormone-dependent transcriptional activation in yeast. Mol. Endocrinol. 8:1245-1252.
26. Lefebvre, P., M. P. Gaub, A. Tahayato, C. Rochette-Egly, and P. Formstecher. 1995. Protein phosphatases 1 and 2A regulate the transcriptional and DNA binding activities of retinoic acid receptors. J. Biol. Chem. 270:10806-10816.
27. Leng, X., J. Blanco, S. Y. Tsai, K. Ozato, B. W. O'Malley, and M.-J. Tsai. 1995. Mouse retinoid X receptor contains a separable ligand-binding and transactivation domain in its E region. Mol. Cell. Biol. 15:255-263.
28. MacDonald, P. N., D. R. Sherman, D. R. Dowd, S. C. Jefcoat, Jr., and R. K. DeLisle. 1995. The vitamin D receptor interacts with general transcription factor IIB. J. Biol. Chem. 270:4748-4752.
29. Mak, P., H. A. Fuernkranz, R. Ge, and S. K. Karathanasis. 1994 Retinoid X receptor homodimers function as transcriptional activators in yeast. Gene 145:129-133.
30. Mangelsdorf, D. J., and R. M. Evans. 1995. The RXR heterodimers and orphan receptors. Cell 83:841-850.
31. Mangelsdorf, D. J., C. Thummel, M. Brain, P. Herrlich, G. Schutz, K. Umesono, P. Kastner, M. Mark, P. Chambon, and R. M. Evans. 1995. The nuclear receptor superfamily: the second decade. Cell 83:835-839.
32. Matkovits, T., and S. Christakos. 1995. Ligand occupancy is not required for vitamin D receptor and retinoid receptor-mediated transcriptional activation. Mol. Endocrinol. 9:232-242.
33. Privalsky, M. L., M. Sharif, and K. R. Yamamoto. 1990. The viral erbA oncogene protein, a constitutive repressor in animal cells, is a hormone-regulated activator in yeast. Cell 63:1277-1286.
34. Qi, J.-S., V. Desai-Yajnik, M. E. Greene, B. M. Raaka, and H. H. Samuels. 1995. The ligand-binding domains of the thyroid hormone/retinoid receptor gene subfamily function in vivo to mediate heterodimerization, gene silencing, and transactivation. Mol. Cell. Biol. 15:1817-1825.
35. Renaud, J.-P., N. Rochel, M. Ruff, V. Vivat, P. Chambon, H. Gronemeyer, and D. Moras. 1995. Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid. Nature (London) 378:681-689.
36. Saatcioglu, F., P. Bartunek, T. Deng, M. Zenke, and M. Karin. 1993. A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor). Mol. Cell. Biol. 13:3675-3685.
37. 36a.Schulman, I. G. Unpublished data.
38. Schulman, I. G., D. Chakravarti, H. Juguilon, A. Romo, and R. M. Evans. 1995. Interactions between the retinoid X receptor and a conserved region of the TATA-binding protein mediate hormone-dependent transactivation. Proc. Natl. Acad. Sci. USA 92:8288-8292.
39. Sucov, H. M., K. Murakami, and R. M. Evans. 1990. Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene. Proc. Natl. Acad. Sci. USA 87:5392-5396.
40. Tumura, H., J. Lazar, M. Phyillaier, and V. M. Nikodem. 1995. The N-terminal region (A/B) of rat thyroid hormone receptor α1, β1, but not β2 contains a strong thyroid hormone-dependent transactivation function. Proc. Natl. Acad. Sci. USA 92:5600-5604.
41. Tong, G.-X., M. R. Tanen, and M. K. Bagchi. 1995. Ligand modulates the interaction of thyroid hormone receptor βwith the basal transcription machinery. J. Biol. Chem. 270:10601-10611.
42. 3 receptors. Cell 65:1255-1266.
43. Valcarcel, R., H. Holz, G. Jimenez, D. Barettino, and H. G. Stunnenberg. 1994. Retinoid-dependent in vitro transcription mediated by the RXR/RAR heterodimer. Genes Dev. 8:3068-3079.
44. Wagner, R. L., J. W. Apriletti, M. E. McGrath, B. L. West, J. D. Baxter, and R. J. Fletterick. 1995. A structural role for hormone in the thyroid hormone receptor. Nature (London) 378:6911-697.
45. Zenke, M., A. Munoz, J. Sap, B. Vennstrom, and H. Beug. 1990. v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA. Cell 61:1035-1049.
46. Zhang, X.-K., G. Salbert, M. O. Lee, and M. Pfahl. 1994. Mutations that alter ligand-induced switches and dimerization activities in the retinoid X receptor. Mol. Cell. Biol. 14:4311-4323.