Structure of the PPARα and -γ ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family

Structure

Volumn 9, Issue 8, 2001, Pages 699-706

  Cronet, Philippe ^a   Petersen, Jens F W ^a   Folmer, Rutger ^a   Blomberg, Niklas ^a   Sjöblom, Kristina ^a   Karlsson, Ulla ^a   Lindstedt, Eva Lotte ^a   Bamberg, Krister ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Activation; Agonist; Ligand binding domain; NMR; PPAR; Structure

Indexed keywords

CELL RECEPTOR; FATTY ACID; LIGAND; TRANSCRIPTION FACTOR; 2 ETHYOXY 3 [4 [2 (4 METHYLSULFONYLOXYPHENYL)ETHOXY]PHENYL]PROPANOIC ACID; CINNAMIC ACID DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; RECEPTOR SUBTYPE; TESAGLITAZAR; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; HYDROGEN BOND; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY; ADIPOCYTE; ANALYTIC METHOD; DRUG RECEPTOR BINDING; FATTY ACID OXIDATION; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DOMAIN;

BINDING SITES; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS; HUMANS; HYDROGEN BONDING; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

EID: 0035431321     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(01)00634-7     Document Type: Article

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