메뉴 건너뛰기




Volumn 59, Issue 17, 1999, Pages 4308-4313

The interaction of raloxifene and the active metabolite of the antiestrogen EM-800 (SC 5705) with the human estrogen receptor

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 METHYL 2 [4 [2 (1 PIPERIDINYL)ETHOXY]PHENYL] 7 PIVALOYLOXY 2H 1 BENZOPYRAN 3 YLPHENYL] PIVALATE; ACOLBIFENE; ANTIESTROGEN; DRUG METABOLITE; ESTRADIOL; ESTROGEN RECEPTOR; FULVESTRANT; MESSENGER RNA; RALOXIFENE; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 0344931629     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (62)

References (38)
  • 1
    • 0031778177 scopus 로고    scopus 로고
    • Basic guide to the mechanisms of antiestrogen action
    • MacGregor, J. I., and Jordan, V. C. Basic guide to the mechanisms of antiestrogen action. Pharmacol. Rev., 50: 151-196, 1998.
    • (1998) Pharmacol. Rev. , vol.50 , pp. 151-196
    • MacGregor, J.I.1    Jordan, V.C.2
  • 2
    • 0032537396 scopus 로고    scopus 로고
    • Tamoxifen for early breast cancer: An overview of the randomized trials
    • Early Breast Cancer Trialists' Collaborative Group. Tamoxifen for early breast cancer: an overview of the randomized trials. Lancet, 351: 1451-1467, 1998.
    • (1998) Lancet , vol.351 , pp. 1451-1467
  • 4
    • 0031026744 scopus 로고    scopus 로고
    • The clinical potential of new antiestrogens
    • Gradishar, W. J., and Jordan, V. C. The clinical potential of new antiestrogens. J. Clin. Oncol., 15: 480-489, 1997.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 480-489
    • Gradishar, W.J.1    Jordan, V.C.2
  • 6
    • 0020694796 scopus 로고
    • Antagonism of estrogen action with a new benzothiophene-derived antiestrogen
    • Black, L. J., Jones, C. D., and Falcone, J. F. Antagonism of estrogen action with a new benzothiophene-derived antiestrogen. Life Sci., 32: 1031-1036, 1983.
    • (1983) Life Sci. , vol.32 , pp. 1031-1036
    • Black, L.J.1    Jones, C.D.2    Falcone, J.F.3
  • 7
    • 0030664688 scopus 로고    scopus 로고
    • Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women
    • Delmas, P. D., Bjamason, N. H., Mitlak, B. H., Ravoux, A-C., Shah, A. S., Huster, W. J., Draper, M., and Christiansen, C. Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women. N. Engl. J. Med., 337: 1641-1647, 1997.
    • (1997) N. Engl. J. Med. , vol.337 , pp. 1641-1647
    • Delmas, P.D.1    Bjamason, N.H.2    Mitlak, B.H.3    Ravoux, A.-C.4    Shah, A.S.5    Huster, W.J.6    Draper, M.7    Christiansen, C.8
  • 8
    • 0032126882 scopus 로고    scopus 로고
    • Molecular mechanism of action of raloxifene and tamoxifen: Today and tomorrow
    • Jordan, V. C. Molecular mechanism of action of raloxifene and tamoxifen: today and tomorrow. J. Natl. Cancer Inst., 90: 967-971, 1998.
    • (1998) J. Natl. Cancer Inst. , vol.90 , pp. 967-971
    • Jordan, V.C.1
  • 11
    • 0028144926 scopus 로고
    • Characterization of tamoxifen stimulated MCF-7 tumor variants grown in athymic mice
    • Wolf, D. M., and Jordan, V. C. Characterization of tamoxifen stimulated MCF-7 tumor variants grown in athymic mice. Breast Cancer Res. Treat., 31: 117-127, 1994.
    • (1994) Breast Cancer Res. Treat. , vol.31 , pp. 117-127
    • Wolf, D.M.1    Jordan, V.C.2
  • 12
    • 0028093565 scopus 로고
    • The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain
    • Wolf, D. M., and Jordan, V. C. The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain. Breast Cancer Res. Treat., 31: 129-138, 1994.
    • (1994) Breast Cancer Res. Treat. , vol.31 , pp. 129-138
    • Wolf, D.M.1    Jordan, V.C.2
  • 13
    • 0029154750 scopus 로고
    • A naturally occurring estrogen receptor mutation results in increased estrogenicity for a tamoxifen analog
    • Catherino, W. H., Wolf, D. M., and Jordan, V. C. A naturally occurring estrogen receptor mutation results in increased estrogenicity for a tamoxifen analog. Mol. Endocrinol., 9: 1053-1063, 1995.
    • (1995) Mol. Endocrinol. , vol.9 , pp. 1053-1063
    • Catherino, W.H.1    Wolf, D.M.2    Jordan, V.C.3
  • 14
    • 0031779534 scopus 로고    scopus 로고
    • The oestrogen-like effect of 4-hydroxytamoxifen on induction of transforming growth factor α mRNA in MDAMB-231 breast cancer cells stably expressing the oestrogen receptor
    • Levenson, A. S., Tonetti D. A., and Jordan, V. C. The oestrogen-like effect of 4-hydroxytamoxifen on induction of transforming growth factor α mRNA in MDAMB-231 breast cancer cells stably expressing the oestrogen receptor. Br. J. Cancer, 77: 1812-1819, 1998.
    • (1998) Br. J. Cancer , vol.77 , pp. 1812-1819
    • Levenson, A.S.1    Tonetti, D.A.2    Jordan, V.C.3
  • 15
    • 0031008040 scopus 로고    scopus 로고
    • Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor
    • Levenson, A. S., Catherino, W. H., and Jordan, V. C. Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor. J. Steroid Biochem. Mol. Biol., 60: 261-268, 1997.
    • (1997) J. Steroid Biochem. Mol. Biol. , vol.60 , pp. 261-268
    • Levenson, A.S.1    Catherino, W.H.2    Jordan, V.C.3
  • 16
    • 2642593030 scopus 로고    scopus 로고
    • The key to the antiestrogenic mechanism of raloxifene is amino acid 351 (Asp) in the estrogen receptor
    • Levenson, A. S., and Jordan, V. C. The key to the antiestrogenic mechanism of raloxifene is amino acid 351 (Asp) in the estrogen receptor. Cancer Res., 58: 1872-1875, 1998.
    • (1998) Cancer Res. , vol.58 , pp. 1872-1875
    • Levenson, A.S.1    Jordan, V.C.2
  • 19
    • 0015027149 scopus 로고
    • Structure-activity relationships of antioestrogens with regard to interaction with 17β-oestradiol in the mouse uterus and vagina
    • Terenius, L. Structure-activity relationships of antioestrogens with regard to interaction with 17β-oestradiol in the mouse uterus and vagina. Acta Endocrinol., 66 (Suppl.): 431-447, 1971.
    • (1971) Acta Endocrinol. , vol.66 , Issue.SUPPL. , pp. 431-447
    • Terenius, L.1
  • 20
    • 0018138311 scopus 로고
    • Non-steroidal antioestrogens: Their biological effects and potential mechanisms of action
    • Jordan, V. C., Dix, C. J., Naylor, K. E., Prestwich, G., and Rowsby, L. Non-steroidal antioestrogens: their biological effects and potential mechanisms of action. J. Toxicol. Environ. Health, 4: 364-390, 1978.
    • (1978) J. Toxicol. Environ. Health , vol.4 , pp. 364-390
    • Jordan, V.C.1    Dix, C.J.2    Naylor, K.E.3    Prestwich, G.4    Rowsby, L.5
  • 21
    • 0014053604 scopus 로고
    • A new derivative of triphenylethylene: Effect on implantation and mode of action in rats
    • Harper, M. J. K., and Walpole, A. L. A new derivative of triphenylethylene: effect on implantation and mode of action in rats. J. Reprod. Fertil., 13: 101-119, 1967.
    • (1967) J. Reprod. Fertil. , vol.13 , pp. 101-119
    • Harper, M.J.K.1    Walpole, A.L.2
  • 22
    • 0017665570 scopus 로고
    • A monohydroxylated metabolite of tamoxifen with potent anti-oestrogenic activity
    • Jordan, V. C., Collins, M. M., Rowsby, L., and Prestwich, G. A monohydroxylated metabolite of tamoxifen with potent anti-oestrogenic activity. J. Endocrinol., 75: 305-316, 1977.
    • (1977) J. Endocrinol. , vol.75 , pp. 305-316
    • Jordan, V.C.1    Collins, M.M.2    Rowsby, L.3    Prestwich, G.4
  • 24
    • 0026395885 scopus 로고
    • A potent specific pure antiestrogen with clinical potential
    • Wakeling, A. E., Dukes, M., and Bowler, J. A potent specific pure antiestrogen with clinical potential. Cancer Res., 51: 3867-3873, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 3867-3873
    • Wakeling, A.E.1    Dukes, M.2    Bowler, J.3
  • 26
    • 0030016280 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacological and anti-tumour effects of the specific anti-oestrogen ICI 182,780 in women with breast cancer
    • Howell, A., DeFriend, D. J., Robertson, J. F. R., Blarney, R. W., Anderson, L., Anderson, E., Sutcliffe, F. A., and Walton, P. Pharmacokinetics, pharmacological and anti-tumour effects of the specific anti-oestrogen ICI 182,780 in women with breast cancer. Br. J. Cancer, 74: 300-308, 1996.
    • (1996) Br. J. Cancer , vol.74 , pp. 300-308
    • Howell, A.1    DeFriend, D.J.2    Robertson, J.F.R.3    Blarney, R.W.4    Anderson, L.5    Anderson, E.6    Sutcliffe, F.A.7    Walton, P.8
  • 27
    • 0026040217 scopus 로고
    • The mechanism of ICI 164,384 antiestrogenicity involves rapid loss of estrogen receptor in uterine tissue
    • Gibson, M. K., Nemmers, L. A., Beckman, W. C., Davis, V. L., Curtis, S. W., and Korach, K. S. The mechanism of ICI 164,384 antiestrogenicity involves rapid loss of estrogen receptor in uterine tissue. Endocrinology, 129: 2000-2010, 1991.
    • (1991) Endocrinology , vol.129 , pp. 2000-2010
    • Gibson, M.K.1    Nemmers, L.A.2    Beckman, W.C.3    Davis, V.L.4    Curtis, S.W.5    Korach, K.S.6
  • 28
    • 0026560435 scopus 로고
    • Antiestrogen ICI 164,384 reduces cellular estrogen receptor by increasing its turnover
    • Dauvois, S., Danielian, P. S., White, R., and Parker, M. G. Antiestrogen ICI 164,384 reduces cellular estrogen receptor by increasing its turnover. Proc. Natl. Acad. Sci. USA, 89: 4037-4041, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 4037-4041
    • Dauvois, S.1    Danielian, P.S.2    White, R.3    Parker, M.G.4
  • 29
    • 0026520381 scopus 로고
    • Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor
    • Jiang, S-Y., and Jordan, V. C. Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor. J. Natl. Cancer Inst., 84: 580-591, 1992.
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 580-591
    • Jiang, S.-Y.1    Jordan, V.C.2
  • 30
    • 0024283936 scopus 로고
    • A versatile in vivo and in vitro eukaryotic vector for protein engineering
    • Green, S., Issemann, I., and Sheer, E. A versatile in vivo and in vitro eukaryotic vector for protein engineering. Nucleic Acids Res., 16: 369, 1988.
    • (1988) Nucleic Acids Res. , vol.16 , pp. 369
    • Green, S.1    Issemann, I.2    Sheer, E.3
  • 31
    • 0018850985 scopus 로고
    • A simple, rapid, and sensitive DNA assay procedure
    • La Barca, C., and Paigen, K. A simple, rapid, and sensitive DNA assay procedure. Anal. Biochem., 102: 344-352, 1980.
    • (1980) Anal. Biochem. , vol.102 , pp. 344-352
    • La Barca, C.1    Paigen, K.2
  • 32
    • 0029883292 scopus 로고    scopus 로고
    • Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines
    • Pink, J. J., and Jordan, V. C. Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines. Cancer Res., 56: 2321-2330, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 2321-2330
    • Pink, J.J.1    Jordan, V.C.2
  • 33
    • 0030879732 scopus 로고    scopus 로고
    • Characterization of the effects of the novel non-steroidal antiestrogen EM-800 on basal and estrogen-induced proliferation of T47D, ZR-75-1 and MCF-7 human breast cancer cells in vitro
    • Simard, J., Labrie, C., Bélanger, A., Gauthier, S., Singh, S. M., Mérand, Y., and Labrie, F. Characterization of the effects of the novel non-steroidal antiestrogen EM-800 on basal and estrogen-induced proliferation of T47D, ZR-75-1 and MCF-7 human breast cancer cells in vitro. Int. J. Cancer, 73: 104-112, 1997.
    • (1997) Int. J. Cancer , vol.73 , pp. 104-112
    • Simard, J.1    Labrie, C.2    Bélanger, A.3    Gauthier, S.4    Singh, S.M.5    Mérand, Y.6    Labrie, F.7
  • 34
    • 0027768899 scopus 로고
    • The antiestrogen ICI 182,780 disrupts estrogen receptor nucleocytoplasmic shuttling
    • Dauvois, S., White, R., and Parker, M. G. The antiestrogen ICI 182,780 disrupts estrogen receptor nucleocytoplasmic shuttling. J. Cell Sci., 106: 1377-1388, 1993.
    • (1993) J. Cell Sci. , vol.106 , pp. 1377-1388
    • Dauvois, S.1    White, R.2    Parker, M.G.3
  • 35
    • 0032446607 scopus 로고    scopus 로고
    • The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
    • Shiau, A. K., Barstad, D., Loria, P. M., Cheng, L., Kushner, P. J., Agard, D. A., and Greene, G. L. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell, 95: 927-937, 1998.
    • (1998) Cell , vol.95 , pp. 927-937
    • Shiau, A.K.1    Barstad, D.2    Loria, P.M.3    Cheng, L.4    Kushner, P.J.5    Agard, D.A.6    Greene, G.L.7
  • 36
    • 0025062215 scopus 로고
    • Role of the two activating domains in the estrogen receptor in the cell type and promoter context dependent agonist activity of the antiestrogen 4-hydroxytamoxifen
    • Berry, M. M., Metzger, D., and Chambon, P. Role of the two activating domains in the estrogen receptor in the cell type and promoter context dependent agonist activity of the antiestrogen 4-hydroxytamoxifen. EMBO J., 9: 2811-2818, 1990.
    • (1990) EMBO J. , vol.9 , pp. 2811-2818
    • Berry, M.M.1    Metzger, D.2    Chambon, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.