A role for helix 3 of the TRβ ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone

EMBO Journal

Volumn 17, Issue 16, 1998, Pages 4760-4770

  Collingwood, Trevor N ^a   Wagner, Richard ^b   Matthews, Clare H ^a   Clifton Bligh, Rory J ^a   Gurnell, Mark ^a   Rajanayagam, Odelia ^a   Agostini, Maura ^a   Fletterick, Robert J ^b   Beck Peccoz, Paolo ^c   Reinhardt, Walter ^k   Binder, Gerhard ^k   Ranke, Michael B ^k   Hermus, Ad ^d   Hesch, Rolf D ^e   Lazarus, John ^f   Newrick, Paul ^g   Parfitt, Vernon ^h   Raggatt, Peter ⁱ   De Zegher, Francis ^j   Chatterjee, V Krishna K ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^e Seestrassel   (Germany)

^f CARDIFF UNIVERSITY   (United Kingdom)

^g Kidderminster General Hospital   (United Kingdom)

^h ROYAL SOUTH HANTS HOSPITAL   (United Kingdom)

ⁱ ADDENBROOKE S HOSPITAL   (United Kingdom)

^j UNIVERSITY OF LEUVEN   (Belgium)

^k NONE

more..

Author keywords

Coactivator; Dominant negative; Resistance to thyroid hormone; Thyroid receptors; Transactivation

Indexed keywords

HORMONE BINDING PROTEIN; MUTANT PROTEIN; THYROID HORMONE RECEPTOR;

ADOLESCENT; ADULT; AGED; ARTICLE; BINDING AFFINITY; BINDING SITE; CLINICAL ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA BINDING; FEMALE; GENE CLUSTER; GENE MUTATION; GENOTYPE; HUMAN; HUMAN CELL; LIGAND BINDING; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DNA BINDING; SCHOOL CHILD; THYROID HORMONE RESISTANCE; TRANSACTIVATION;

AMINO ACID SEQUENCE; CELL LINE; DIMERIZATION; GENES, DOMINANT; GENOTYPE; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; REPRESSOR PROTEINS; RETINOID X RECEPTORS; THYROID HORMONE RESISTANCE SYNDROME; THYROID HORMONES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 0032541336     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.16.4760     Document Type: Article

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