The Human Estrogen Receptor-α is a Ubiquitinated Protein Whose Stability is Affected Differentially by Agonists, Antagonists, and Selective Estrogen Receptor Modulators

Journal of Biological Chemistry

Volumn 276, Issue 38, 2001, Pages 35684-35692

  Wijayaratne, Ashini L ^b   McDonnell, Donald P ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; DEGRADATION; HORMONES; HUMAN ENGINEERING;

TRANSCRIPTIONAL ACTIVITY;

PROTEINS;

ANTIESTROGEN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FULVESTRANT; GE 7604; GW 7604; PROTEASOME; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; UNCLASSIFIED DRUG; ESTROGEN RECEPTOR; LIGAND; UBIQUITIN;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VIVO STUDY; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN STABILITY; RECEPTOR INTRINSIC ACTIVITY; TRANSCRIPTION REGULATION; CELL CULTURE; DRUG EFFECT; DRUG POTENTIATION; METABOLISM;

ESTROGEN ANTAGONISTS; ESTROGEN RECEPTOR ALPHA; HUMANS; LIGANDS; RECEPTORS, ESTROGEN; TUMOR CELLS, CULTURED; UBIQUITINS;

EID: 0035929585     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M101097200     Document Type: Article

References (56)

1. Beekman, J. M., Allan, G. F., Tsai, S. Y., Tsai, M.-J., and O'Malley, B. W. (1993) Mol. Endocrinol. 7, 1266-1274
2. Horwitz, K. B., Jackson, T. A., Bain, D. L., Richer, J. K., Takimoto, G. S., and Tung, L. (1996) Mol. Endocrinol. 10, 1167-1177
3. Paige, L. A., Christensen, D. J., Gron, H., Norris, J. D., Gottlin, E. B., Padilla, K. M., Chang, C., Ballas, L. M., Hamilton, P. T., McDonnell, D. P., and Fowlkes, D. M. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3999-4004
4. McDonnell, D. P., Clemm, D. L., Herman, T., Goldman, M. E., and Pike, J. W. (1995) Mol. Endocrinol. 9, 659-669
5. Wijayaratne, A. L., Nagel, S. C., Paige, L. A., Christensen, D. J., Norris, J. D., Fowlkes, D. M., and McDonnell, D. P. (1999) Endocrinology 140, 5828-5840
6. Xiaodong, L., and Huebner, V. (2000) Curr. Opin. Drug Discovery Dev. 3, 383-398
7. Brzozowski, A. M., Pike, A. C., Dauter, Z., Hubbard, R. E., Bonn, T., Engstrom, O., Ohman, L., Greene, G. L., Gustafsson, J. A., and Carlquist, M. (1997) Nature 389, 753-758
8. Shiau, A. K., Barstad, D., Loria, P. M., Cheng, L., Kushner, P. J., Agard, D. A., and Greene, G. L. (1998) Cell 95, 927-937
9. Onate, S. A., Tsai, S., Tsai, M.-J., and O'Malley, B. W. (1995) Science 270, 1354-1357
10. Smith, C. L., Nawaz, Z., and O'Malley, B. W. (1997) Mol. Endocrinol. 11, 657-666
11. Jackson, T. A., Richer, J. K., Bain, D. L., Takimoto, G. S., Tung, L., and Horwitz, K. B. (1997) Mol. Endocrinol. 11, 693-705
12. Lavinsky, R. M., Jepsen, K., Heinzel, T., Torchia, J., Mullen, T. M., Schiff, R., Del-Rio, A. L., Ricote, M., Ngo, S., Gemsch, J., Hilsenbeck, S. G., Osborne, C. K., Glass, C. K., Rosenfeld, M. G., and Rose, D. W. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 2920-2925
13. Eckert, R. L., Mullick, A., Rorke, E. A., and Katzenellenbogen, B. S. (1984) Endocrinology 114, 629-637
14. Monsma, F. J., Katzenellenbogen, B. S., Miller, M. A., Ziegler, Y. S., and Katzenellenbogen, J. A. (1984) Endocrinology 115, 143-153
15. Scholl, S., and Lippman, M. E. (1984) Endocrinology 115, 1295-1301
16. Nardulli, A. M., and Katzenellenbogen, B. S. (1986) Endocrinology 119, 2038-2046
17. Dauvois, S., Danielian, P. S., White, R., and Parker, M. G. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 4037-4041
18. Ciechanover, A. (1994) Cell 79, 13-21
19. Molinari, E., Gilman, M., and Natesan, S. (1999) EMBO J. 18, 6439-6447
20. Salghetti, S. E., Muratani, M., Wijnen, H., Futcher, B., and Tansey, W. P. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 3118-3123
21. Lonard, D. M., Nawaz, Z., Smith, C. L., and O'Malley, B. W. (2000) Mol. Cell 5, 939-948
22. Nawaz, Z., Lonard, D. M., Dennis, A. P., Smith, C. L., and O'Malley, B. W. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 1858-1862
23. El Khissiin, A., and Leclercq, G. (1999) FEBS Lett. 448, 160
24. Alarid, E. T., Bakopoulos, N., and Solodin, N. (1999) Mol. Endocrinol. 13, 1522
25. Norris, J., Fan, D., and McDonnell, D. P. (1996) Mol. Endocrinol. 10, 1605-1616
26. Schreiber, E., Matthias, P., Müller, M. M., and Schaffner, W. (1988) EMBO J. 7, 4221-4229
27. Dana, S. L., Hoener, P. A., Wheeler, D. L., Lawrence, C. L., and McDonnell, D. P. (1994) Mol. Endocrinol, 8, 1193-1207
28. Mak, H. Y., Hoare, S., Henttu, P. M. A., and Parker, M. G. (1999) Mol. Cell. Biol. 19, 3895-3903
29. Norris, J., Fan, D., Aleman, C., Marks, J. R., Futreal, A., Wiseman, R. W., Iglehart, J. D., Deininger, P. L., and McDonnell, D. P. (1995) J. Biol. Chem. 270, 22777-22782
30. Treier, M., Staszewski, L. M., and Bohmann, D. (1994) Cell 78, 787-798
31. Staub, O., Gautschi, I., Ishikawa, T., Breitschopf, K., Ciechanover, A., Schild, L., and Rotin, D. (1997) EMBO J. 16, 6325-6336
32. Norris, J. D., Fan, D., M. R., S., and McDonnell, D. P. (1998) J. Biol. Chem. 273, 6679-6688
33. Chang, C., Norris, J. D., Gron, H., Paige, L. A., Hamilton, P. T., Kenan, D. J., Fowlkes, D., and McDonnell, D. P. (1999) Mol. Cell. Biol. 19, 8226-8239
34. Sadowski, I., Ma, J., Triezenberg, S., and Ptashne, M. (1988) Nature 335, 563-564
35. Gaub, M. P., Bellard, M., Scheuer, I., Chambon, P., and Sassone-Corsi, P. (1990) Cell 63, 1267-1276
36. Phillips, A., Chalbos, D., and Rochefort, H. (1993) J. Biol. Chem. 268, 14103-14108
37. Dauvois, S., White, R., and Parker, M. G. (1993) J. Cell Sci. 106, 1377-1388
38. Fenteany, G., Standaert, R. F., Lane, W. S., Choi, S., Corey, E. J., and Schreiber, S. L. (1995) Science 268, 726-731
39. Ohkuma, S., and Poole, B. (1981) J. Cell Biol. 90, 665-669
40. Fenteany, G., Standaert, R. F., Reichard, G. A., Coerey, E. J., and Schreiber, S, L. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 3358-3362
41. Chau, V., Tobias, J. W., Bachmair, A., Marriott, D., Ecker, D. J., Gonda, D. K., and Varshavsky, A. (1989) Science 243, 1576-1583
42. Gregori, L., Poosch, M. S., Cousins, G., and Chau, V. (1990) J. Biol. Chem. 265, 8354-8357
43. Thrower, J. S., Hoffman, L., Rechsteiner, M., and Pickart, C. M. (2000) EMBO J. 19, 94-102
44. Norris, J. D., Paige, L. A., Christensen, D. J., Chang, C. Y., Huacani, M. R., Fan, D., Hamilton, P. T., Fowlkes, D. M., and McDonnell, D. P. (1999) Science 285, 744-746
45. Gottardis, M. M., and Jordan, V. C. (1988) Cancer Res. 48, 5183-5187
46. Katzenellenbogen, B. S., Montano, M. M., Le Goff, P., Schodin, D. J., Kraus, W. L., Bhardwaj, B., and Fujimoto, N. (1995) J. Steroid Biochem. Mol. Biol. 53, 387-393
47. Howell, A., DeFriend, D., Robertson, J., Blamey, R., and Walton, P. (1995) Lancet 345, 29-30
48. Connor, C. E., Norrisa, J. D., Broadwater, G., Willson, T. M., Gottardis, M. M., Dewhirst, M. W., and McDonnell, D. P. (2001) Cancer Res. 61, 2917-2922
49. Imhof, M. O., and McDonnell, D. P. (1996) Mol. Cell. Biol. 16, 2594-2605
50. Zhang, J., Guenther, M. G., Carthew, R. W., and Lazar, M. A. (1998) Genes Dev. 12, 1775-1780
51. Lee, J. W., Ryan, F., Swaffield, J. C., Johnston, S. A., and Moore, D. D. (1995) Nature 374, 91-94
52. vom Baur, E., Zechel, C., Heery, D., Heine, M. J. S., Garnier, J. M., Vivat, V., Le Douarin, B., Gronemeyer, H., Chambon, P., and Losson, R. (1995) EMBO J. 14, 110-124
53. Poukka, H., Aarnisalo, P., Karvonen, U., Palvimo, J. J., and Janne, O. A. (1999) J. Biol. Chem. 274, 19441-19446
54. Htun, H., Holth, L. T., Walker, D., Davie, J. R., and Hager, G. L. (1999) Mol. Biol. Cell 10, 471-486
55. Peters, J.-M., Franke, W. W., and Kleinschmid, J. A. (1994) J. Biol. Chem. 269, 7709-7718
56. Reits, E. A., Benham, A. M., Plougastel, B., Neefjes, J., and Trowsdale, J. (1997) EMBO J. 16, 6087-6094