Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen

Molecular Endocrinology

Volumn 11, Issue 6, 1997, Pages 657-666

  Smith, Carolyn L ^a   Nawaz, Zafar ^a   O'Malley, Bert W ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN; ANTIESTROGEN; ESTROGEN RECEPTOR;

ARTICLE; GENE EXPRESSION REGULATION; HELA CELL; HORMONAL REGULATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

EID: 0030946198     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.11.6.0009     Document Type: Article

References (60)

1. Evans RM 1988 The steroid and thyroid hormone receptor superfamily. Science 240:889-895
2. Tsai M-J, O'Malley BW 1994 Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem 63:451-486
3. Beekman JM, Allan GF, Tsai SY, Tsai M-J, O'Malley BW 1993 Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain. Mol Endocrinol 7:1266-1274
4. Tsai SY, Carlstedt-Duke J, Weigel NL, Dahlman K, Gustafsson J-A, Tsai M-J, O'Malley BW 1988 Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formation. Cell 55:361-369
5. Kumar V, Chambon P 1988 The estrogen receptor binds tightly to its response element as a ligand-induced homodimer. Cell 55:145-156
6. Tora L, White J, Brou C, Tasset D, Webster N, Scheer E, Chambon P 1989 The human estrogen receptor has two independent nonacidic transcriptional activation functions. Cell 59:477-487
7. Lees JA, Fawell SE, Parker MG 1989 Identification of two transactivation domain in the mouse oestrogen receptor. Nucleic Acids Res 17:5477-5487
8. Tzukerman MT, Esty A, Santiso-Mere D, Danielian P, Parker MG, Stein RB, Pike JW, McDonnell DP 1994 Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. Mol Endocrinol 8:21-30
9. Pham TA, Hwung Y-P, Santiso-Mere D, McDonnell DP, O'Malley BW 1992 Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast. Mol Endocrinol 6:1043-1050
10. Wakeling AE 1990 Novel pure antiestrogens: mode of action and therapeutic prospects. Ann NY Acad Sci 595:348-356
11. Wakeling AE, Dukes M, Bowler J 1991 A potent specific pure antiestrogen with clinical potential. Cancer Res 51:3867-3873
12. Katzenellenbogen JA, O'Malley BW, Katzenellenbogen BS 1996 Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones. Mol Endocrinol 10:119-131
13. Webster NJG, Green S, Jin JR, Chambon P 1988 The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell 54:199-207
14. Berry M, Metzger D, Chambon P 1990 Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen. EMBO J 9:2811-2818
15. Osborne CK, Coronado E, Allred DC, Wiebe V, DeGregorio M 1991 Acquired tamoxifen resistance: correlation with reduced breast tumor levels of tamoxifen and isomerization of trans-4-hydroxytamoxifen. J Natl Cancer Inst 83:1477-1482
16. Gottardis MM, Jiang SY, Jeng MH, Jordan VC 1989 Inhibition of tamoxifen-stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens. Cancer Res 49:4090-4093
17. Gottardis MM, Robinson SP, Satyaswaroop PG, Jordan VC 1988 Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse. Cancer Res 48:812-815
18. Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L 1996 Nuclear receptor coactivators and corepressors. Mol Endocrinol 10:1167-1177
19. Shibata H, Spencer TE, Oñate SA, Jenster G, Tsai SY, Tsai M-J, O'Malley BW 1997 Role of coactivators and corepressors in the mechanism of steroid/thyroid receptor action. Recent Prog Horm Res, in press
20. Ogryzko W, Schiltz RL, Russanova V, Howard BH, Nakatani Y 1996 The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87:953-959
21. Halachmi S, Marden E, Martin G, MacKay H, Abbondanza C, Brown M 1994 Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription. Science 264:1455-1458
22. Oñate SA, Tsai SY, Tsai M-J, O'Malley BW 1995 Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270:1354-1357
23. Chen JD, Evans RM 1995 A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377:454-457
24. Norris JD, Fan D, Wagner BL, McDonnell DP 1996 Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity. Mol Endocrinol 10:1605-1616
25. Webb P, Lopez GN, Uht RM, Kushner PJ 1995 Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens. Mol Endocrinol 9:443-456
26. Vik DP, Amiguet P, Moffat GJ, Fey M, Amiguet-Barras F, Wetsel RA, Tack BF 1991 Structural features of the human C3 gene: intron/exon organization, transcriptional start site, and promoter region sequence. Biochemistry 30:1080-1085
27. Juan TS, Wilson DR, Wilde MD, Darlington GJ 1993 Participation of the transcription factor C/EBP delta in the acute-phase regulation of the human gene for complement component C3. Proc Natl Acad Sci USA 90:2584-2588
28. Danielian PS, White R, Lees JA, Parker MG 1992 Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J 11:1025-1033
29. Smith CL, Conneely OM, O'Malley BW 1993 Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone. Proc Natl Acad Sci USA 90:6120-6124
30. Power RF, Mani SK, Codina J, Conneely OM, O'Malley BW 1991 Dopaminergic and ligand-independent activation of steroid hormone receptors. Science 254:1636-1639
31. Aronica SM, Katzenellenbogen BS 1993 Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-1. Mol Endocrinol 7:743-752
32. Fujimoto N, Katzenellenbogen BS 1994 Alteration in the agonist/antagonist balance of antiestrogens by activation of protein kinase A signaling pathways in breast cancer cells: antiestrogen selectively and promoter dependence. Mol Endocrinol 8:296-304
33. McDonnell DP, Clemm DL, Hermann T, Goldman ME, Pike JW 1995 Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens. Mol Endocrinol 9:659-669
34. Mclnerney EM, Tsai M-J, O'Malley BW, Katzenellenbogen BS 1996 Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator. Proc Natl Acad Sci USA 93:10069-10073
35. Takeshita A, Yen PM, Misiti S, Cardona GR, Liu Y, Chin WW 1996 Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator. Endocrinology 137:3594-3597
36. Smith CL, Conneely OM, O'Malley BW 1995 Oestrogen receptor activation in the absence of ligand. Biochem Soc Trans 23:935-939
37. Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin S-C, Heyman RA, Rose DW, Glass CK, Rosenfeld MG 1996 A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85:403-414
38. Lundblad JR, Kwok RPS, Laurance ME, Harter ML, Goodman RH 1995 Adenoviral EIA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature 374:85-88
39. Janknecht R, Nordheim A 1996 MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP. Biochem Biophys Res Commun 228:831-837
40. Bannister AJ, Oehler T, Wilhelm D, Angel P, Kouzarides T 1995 Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene 11:2509-2514
41. Dai P, Akimaru H, Tanaka Y, Hou D-X, Yasukawa T, Kanei-lshii C, Takahashi T, Ishii S 1996 CBP as a transcriptional coactivator of c-Myb. Genes Dev 10:528-540
42. Bannister AJ, Kouzarides T 1995 CBP-induced stimulation of c-Fos activity is abrogated by EIA. EMBO J 14:4758-4762
43. Kurokawa R, Söderström M, Hörlein A, Halachmi S, Brown M, Rosenfeld MG, Glass CK 1995 Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature 377:451-454
44. 3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors. Mol Endocrinol 10:813-825
45. Zamir I, Harding HP, Atkins GB, Hörlein A, Glass CK, Rosenfeld MG, Lazar MA 1996 A nuclear hormone receptor corepressor mediates transcriptional silencing by receptors with distinct repression domains. Mol Cell Biol 16:5458-5465
46. Downes M, Burke LJ, Muscat GEO 1996 Transcriptional repression by Rev-erbAα is dependent on the signature motif and helix 5 in the ligand binding domain: silencing does not involve an interaction with N-CoR. Nucleic Acids Res 24:3490-3498
47. Shibata H, Nawaz Z, Tsai SY, O'Malley BW, Tsai M-J Gene silencing by COU P-TFI is mediated by transcriptional corepressors N-CoR and SMRT. Mol Endocrinol, in press
48. Smith DF, Toft DO 1993 Steroid receptors and their associated proteins. Mol Endocrinol 7:4-11
49. Reese JC, Katzenellenbogen BS 1992 Examination of the DNA-binding ability of estrogen receptor in whole cells: implications for hormone-independent transactivation and the actions of antiestrogens. Mol Cell Biol 12:4531-4538
50. Lee HS, Aumais J, White JH 1996 Hormone-dependent transactivation by estrogen receptor chimeras that do not interact with hsp90. J Biol Chem 271:25727-25730
51. Xu J, Nawaz Z, Tsai SY, Tsai M-J, O'Malley BW 1996 The extreme C terminus of progesterone receptor contains a transcriptional repressor domain that functions through a putative corepressor. Proc Natl Acad Sci USA 93: 12195-12199
52. Cavailles V, Dauvois S, L'Horset F, Lopez G, Hoare S, Kushner PJ, Parker MG 1995 Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J 14:3741-3751
53. Yao T-P, Ku G, Zhou N, Scully R, Livingston DM 1996 The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc Natl Acad Sci USA 93:10626-10631
54. Voegel JJ, Heine MJS, Zechel C, Chambon P, Gronemeyer H 1996 TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J 15:3667-3675
55. Chen JD, Umesono K, Evans RM 1996 SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers. Proc Natl Acad Sci USA 93:7567-7571
56. Hörlein AJ, Naar AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Söderström M, Glass CK, Rosenfeld MG 1995 Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377:397-404
57. Santen RJ 1996 Editorial: Long term tamoxifen therapy: can an antagonist become an agonist? J Clin Endocrinol Metab 81:2027-2029
58. Fisher B, Costantino JP, Redmond CK, Fisher ER, Wickerham DL, Cronin WM 1994 Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14. J Natl Cancer Inst 86:527-537
59. Allan GF, Leng XH, Tsai SY, Weigel NL, Edwards DP, Tsai M-J, O'Malley BW 1992 Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation. J Biol Chem 267: 19513-19520
60. Baniahmad C, Nawaz Z, Baniahmad A, Gleeson MAG, Tsai M-J, O'Malley BW 1995 Enhancement of human estrogen receptor activity by SPT6: a potential coactivator. Mol Endocrinol 9:34-43