Structural insights into the mode of action of a pure antiestrogen

Structure

Volumn 9, Issue 2, 2001, Pages 145-153

  Pike, Ashley C W ^a   Brzozowski, A Marek ^a   Walton, Julia ^a   Hubbard, Roderick E ^a   Thorsell, Ann Gerd ^b   Li, Yi Lin ^b   Gustafsson, Jan Åke ^c   Carlquist, Mats ^b  

^a UNIVERSITY OF YORK   (United Kingdom)

^b Karo Bio   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Estrogen receptor; ICI 164,384; Pure antiestrogen; Receptor antagonism; Transactivation

Indexed keywords

ANTIESTROGEN; ESTROGEN RECEPTOR; N BUTYL 11 (3,17BETA DIHYDROXYESTRA 1,3,5(10) TRIEN 7ALPHA YL) N METHYLUNDECANAMIDE;

ARTICLE; BINDING SITE; DRUG MECHANISM; DRUG PROTEIN BINDING; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ESTRADIOL; ESTROGEN ANTAGONISTS; ESTROGEN RECEPTOR BETA; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; POLYUNSATURATED ALKAMIDES; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, ESTROGEN;

EID: 0035099225     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(01)00568-8     Document Type: Article

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