Coactivator peptides have a differential stabilizing effect on the binding of Estrogens and Antiestrogens with the estrogen receptor

Molecular Endocrinology

Volumn 13, Issue 11, 1999, Pages 1912-1923

  Gee, Arvin C ^a   Carlson, Kathryn E ^a   Martini, Paolo G V ^b   Katzenellenbogen, Benita S ^b   Katzenellenbogen, John A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIESTROGEN; DIETHYLSTILBESTROL; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; FULVESTRANT; STEROID RECEPTOR COACTIVATOR 1;

ARTICLE; BINDING KINETICS; CONTROLLED STUDY; DISSOCIATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; GENETIC TRANSCRIPTION; PRIORITY JOURNAL; STOICHIOMETRY;

EID: 0033305430     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.11.0373     Document Type: Article

References (51)

1. Comparative QSAR analysis of estrogen receptor ligands
2. ERβ: Identification and characterization of a novel human estrogen receptor
3. The novel estrogen receptor-β subtype: Potential role in the cell- and promoter-specific actions of estrogens and anti-estrogens
4. Selective estrogen receptor modulators (SERMS)
5. The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors
6. GRIP1, A transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors
7. Co-activators and co-repressors in the integration of transcriptional responses
8. Coactivators and corepressors as mediators of nuclear receptor function - An update
9. Nuclear receptor coactivators and corepressors
10. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
11. Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): Multiple motifs with different binding specificities
12. A possible involvement of TIF1-α and TIF1-β In the epigenetic control of transcription by nuclear receptors
13. A signature motif in transcriptional co-activators mediates binding to nuclear receptors
14. Structure and specificity of nuclear receptor-coactivator interactions
15. Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors
16. Molecular determinants of the estrogen receptor-coactivator interface
17. Molecular basis of agonism and antagonism in the oestrogen receptor
18. X-ray crystallographic and functional studies of thyroid hormone receptor
19. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
20. 5,6,11,12-Tetrahydrochrysenes: Synthesis of rigid stilbene systems designed to be fluorescent ligands for the estrogen receptor
21. Donor-acceptor tetrahydrochrysenes, inherently fluorescent, high-affinity ligands for the estrogen receptor: Binding and fluorescence characteristics and fluorometric assay of receptor
22. Studies using fluorescent tetrahydrochrysene estrogens for in situ visualization of the estrogen receptor in living cells
23. Photoaffinity labels for estrogen binding proteins of rat uterus
24. Altered ligand binding properties and enhanced stability of a constitutively active estrogen receptor: Evidence that an open pocket conformation is required for ligand interaction
25. Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein
26. Determination of tamoxifen and metabolites in human serum by high-performance liquid chromatography with post-column fluorescence activation
27. The Binding of Small Molecules to Proteins
28. Strength in numbers - Non-natural polyvalent carbohydrate derivatives
29. β-Adrenoceptor antagonist activity of bivalent Ligands. 1. Diiamide analogues of practolol
30. The role of concepts in structure activity relationship studies of opioid ligands
31. Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors
32. Dimeric enkephalins display enhanced affinity and selectivity for the δ opiate receptor
33. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
34. Application of fluorescence resonance energy transfer in the clinical laboratory: Routine and research
35. Ligand selectivity of the peroxisome proliferator-activated receptor α
36. Pure and functionally homogeneous recombinant retinoid X receptor
37. On the role of ligand in retinoid signaling - Positive cooperativity in the interactions of 9-cis-retinoic acid with tetramers of the retinoid X receptor
38. Role of ligand in retinoid signaling - 9-cis-retinoic acid modulates the oligomeric state of the retinoid X receptor
39. Retinoid X receptor α forms tetramers in solution
40. Equilibrium binding of estrogen receptor with DNA using fluorescence anisotropy
41. Nuclear receptors have distinct affinities for coactivators - Characterization by fluorescence resonance energy transfer
42. Rapid screening of environmental chemicals for estrogen receptor binding capacity
43. The tetramerization region of the retinoid X receptor is important for transcriptional activation by the receptor
44. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
45. Proteasome-dependent degradation of the human estrogen receptor
46. Composite co-activator ARC mediates chromatin-directed transcriptional activation
47. A new actor in the estrogen receptor drama-enter ER-β
48. Tripartite steroid hormone receptor pharmacology: Interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones
49. Analysis of mechanisms that determine dominant negative estrogen receptor effectiveness
50. Examination of the DNA binding abilities of estrogen receptor in whole cells: Implications for hormone-independent transactivation and the action of the pure antiestrogen ICI164,384
51. The quinone reductase gene: A unique estrogen receptor-regulated gene that is activated by antiestrogens