Altered ligand binding properties and enhanced stability of a constitutively active estrogen receptor: Evidence that an open pocket conformation is required for ligand interaction

Biochemistry

Volumn 36, Issue 48, 1997, Pages 14897-14905

  Carlson, Kathryn E ^a   Choi, Inho ^b   Gee, Arvin ^a   Katzenellenbogen, Benita S ^b   Katzenellenbogen, John A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; LIGAND; UREA;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING KINETICS; DISSOCIATION; IMMUNOBLOTTING; LIGAND BINDING; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR BINDING;

BINDING SITES; ESTRADIOL; GUANIDINE; HUMANS; LIGANDS; MODELS, CHEMICAL; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN DENATURATION; RECEPTORS, ESTROGEN; RECOMBINANT PROTEINS; TYROSINE; UREA;

ANIMALIA;

EID: 0030734795     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi971746l     Document Type: Article

References (42)

1. Parker, M. G. (1991) Nuclear Hormone Receptors, Academic Press, London.
2. Tsai, M.-J., and O'Malley, B. W. (1994) Annu. Rev. Biochem. 63, 451-486.
3. Wahli, W., and Martinez, E. (1991) FASEB J. 5, 2243-2249.
4. Beato, M., Herrlich, P., and Schutz, G. (1995) Cell 83, 851-857.
5. Katzenellenbogen, J. A., O'Malley, B. W., and Katzenellenbogen, B. S. (1996) Mol. Endocrinol. 10, 119-131.
6. Katzenellenbogen, B. S., Fang, H., Ince, B. A., Pakdel, F., Reese, J. C., Wooge, C. H., and Wrenn, C. K. (1993) Breast Cancer Res. Treat. 27, 17-26.
7. Weis, K. E., Ekena, K., Thomas, J. A., Lazennec, G., and Katzenellenbogen, B. S. (1996) Mol. Endocrinol. 10, 1388-1398.
8. Thole, H. H., Maschler, I., and Jungblut, P. W. (1995) Eur. J. Biochem. 231, 510-516.
9. Trapp, T., and Holsboer, F. (1995) Biochem. Biophys. Res. Commun. 215, 286-291.
10. Leid, M. (1994) J. Biol. Chem. 269, 14175-14181.
11. Halachmi, S., Marden, E.. Martin, G., MacKay, H., Abbondanza, C., and Brown, M. (1994) Science 264, 1455-1458.
12. Hansen, J. C., and Gorski, J. (1985) Biochemistry 24, 6078-6085.
13. Oñate, S. A., Tsai, S. Y., Tsai, M. J., and O'Malley, B. W. (1995) Science 270, 1354-1357.
14. Horwitz, K. B., Jackson, T. A., Rain, D. L., Richer, J. K., Takimoto, G. S., and Tung, L. (1996) Mol. Endocrinol. 10, 1167-1177.
15. Allan, G. F., Leng, X., Tsai, S. Y., Weigel, N. L., Edwards, D. P., Tsai, M.-J., and O'Malley, B. W. (1992) J. Biol. Chem. 267, 19513-19520.
16. Renaud, J.-P., Rochel, N., Ruff, M., Vivat, V., Chambon, P., Gronemeyer, H., and Moras, D. (1995) Nature 378, 681-689.
17. Wagner, R. L., Apriletti, J. W., McGrath, M. E., West, B. L., Baxter, J. D., and Fletterick, R. J. (1995) Nature 378, 690-697.
18. Bourguet, W., Ruff, M., Chambon, P., Gronemeyer, H., and Moras, D. (1995) Nature 375, 377-382.
19. White, R., Sjöberg, M., Kalkhoven, E., and Parker, M. G. (1997) EMBO J. 16, 1427-1435.
20. Zhang, Q.-X., Borg, Å., Wolf, D. M., Oesterreich, S., and Fuqua, S. A. W. (1997) Cancer Res. 57, 1244-1249.
21. Pakdel, F., Reese, J. C., and Katzenellenbogen, B. S. (1993) Mol. Endocrinol. 7, 1408-1417.
22. Lazennec, G., Ediger, T. R., Petz, L. N., Nardulli, A. M., and Katzenellenbogen, B. S. (1997) Mol. Endocrinol. 11, 1375-1386.
23. Williams, D., and Gorski, J. (1974) Biochemistry 13, 5537-5542.
24. Pakdel, F., and Katzenellenbogen, B. S. (1992) J. Biol. Chem. 267, 3429-3437.
25. Seielstad, D. A., Carlson, K. E., Katzenellenbogen, J. A., Kushner, P. J., and Greene, G. L. (1995) Mol. Endocrinol. 9, 647-658.
26. Schagger, H., and von Jagow, G. (1987) Anal. Biochem. 166, 368-379.
27. Salomonsson, M., Carlsson, B., and Häggblad, J. (1994) J. Steroid Biochem. Mol. Biol. 50, 368-379.
28. Scatchard, G. (1949) Ann. N.Y. Acad. Sci. 51, 660-672.
29. Wrenn, C. K., and Katzenellenbogen, B. S. (1993) J. Biol. Chem. 268, 24089-24098.
30. Zhou, Z.-X., Lane, M. V., Kemppainen, J. A., French, F. S., and Wilson, E. M. (1995) Mol. Endocrinol. 9, 208-218.
31. Kuiper, G. G., Enmark, E., Pelto-Huikko, M., Nilsson, S., and Gustafsson, J. A. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 5925-5930.
32. Mosselman, S., Polman, J., and Dijkema, R. (1996) FEBS Lett. 392, 49-53.
33. Auricchio, F., Migliaccio, A., Di Domenico, M., and Nola, E. (1987) EMBO J. 6, 2923-2929.
34. Ignar-Trowbridge, D. M., Nelson, K. G., Bidwell, M. C., Curtis, S. W., Washburn, T. F., McLachlan, J. A., and Korach, K. S. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 4658-4662.
35. Ignar-Trowbridge, D. M., Pimentel, M., Parker, M. G., McLachlan, J. A., and Korach, K. S. (1996) Endocrinology 137, 1735-1744.
36. Aronica, S. M., and Katzenellenbogen, B. S. (1993) Mol. Endocrinol. 7, 743-752.
37. Arnold, S. F., Obourn, J. D., Jaffe, H., and Notides, A. C. (1995) Mol. Endocrinol. 9, 24-33.
38. Arnold, S. F., Vorojeikina, D. P., and Notides, A. C. (1995) J. Biol. Chem. 270, 30205-30212.
39. Arnold, S. F., Melamed, M., Vorojeikina, D. P., Notides, A. C., and Sasson, S. (1997) Mol. Endocrinol. 11, 48-53.
40. Boone, C., Davis, N. G., and Sprague, G. F., Jr. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 9921-9925.
41. Ren, Q., Hitoshi, K., Lefkowitz, R. J., and Cotecchia, S. (1993) J. Biol. Chem. 268, 16483-16487.
42. Samama, P., Cotecchia, S., Costa, T., and Lefkowitz, R. J. (1993) J. Biol. Chem. 268, 4625-4636.