Structural basis for the deactivation of the estrogen-related receptor γ by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity

Journal of Biological Chemistry

Volumn 279, Issue 32, 2004, Pages 33639-33646

  Greschik, Holger ^a   Flaig, Ralf ^a   Renaud, Jean Paul ^a   Moras, Dino ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY;

ESTROGENS; LIGAND BINDING DOMAIN (LBD); RALOXIFENE;

BIOCHEMISTRY;

4 HYDROXYTAMOXIFEN; DIETHYLSTILBESTROL; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RELATED RECEPTOR GAMMA; HORMONE RECEPTOR STIMULATING AGENT; PHENYLALANINE; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG RECEPTOR BINDING; LIGAND BINDING; LIGAND BINDING DOMAIN; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR DOWN REGULATION; ROTATION;

ANIMALS; BINDING SITES; CRYSTALLIZATION; DIETHYLSTILBESTROL; DIMERIZATION; ESTROGEN ANTAGONISTS; ESTROGEN RECEPTOR ALPHA; ESTROGENS, NON-STEROIDAL; MICE; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RALOXIFENE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, ESTROGEN; RECOMBINANT PROTEINS; TAMOXIFEN;

EID: 4043176291     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M402195200     Document Type: Article

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