Response element and coactivator-mediated conformational change of the vitamin D3 receptor permits sensitive interaction with agonists

Molecular Pharmacology

Volumn 57, Issue 6, 2000, Pages 1206-1217

  Herdick, Michaela ^b   Bury, Yvonne ^b   Quack, Marcus ^b   Uskokovic, Milan R ^b   Polly, Patsie ^b   Carlberg, Carsten ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

20 METHYL 1,25 DIHYDROXYVITAMIN D3; 20 METHYLCALCITRIOL; CALCITRIOL DERIVATIVE; DNA; GLUTATHIONE TRANSFERASE; LEXACALCITOL; LIGAND; PROTEINASE; RETINOID X RECEPTOR; RO 27 2310; STEROID RECEPTOR COACTIVATOR 1; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ANIMAL CELL; ARTICLE; CERCOPITHECIDAE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CALCITRIOL; COS CELLS; HUMANS; PROTEIN CONFORMATION; RABBITS; RECEPTORS, CALCITRIOL;

EID: 0034081880     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. 3 analogues: A novel class of potent regulators of cell growth and immune responses. Biochem Pharmacol 42:1569-1575.
2. Bouillon R, Okamura WH and Norman AW (1995) Structure-junction relationships in the vitamin D endocrine system. Endocr Rev 16:200-257.
3. 3: Interplay with retinoid and thyroid hormone signalling. Eur J Biochem 231:517-527.
4. Carlberg C, Bendik I, Wyss A, Meier E, Sturzenbecker LJ, Grippo JF and Hunziker W (1993) Two nuclear signalling pathways for vitamin D. Nature (Lond) 361:657-660.
5. Carlberg C and Polly P (1998) Gene regulation by vitamin D3. Crit Rev Eukaryot Gene Expr 8:19-42.
6. Chen JD and Li H (1998) Coactivation and corepression in transcriptional regulation by steroid/nuclear hormone receptors. Crit Rev Eukaryotic Gene Expr 8:169-190.
7. DeLuca HF, Krisinger J and Darwish H (1990) The vitamin D system. Kidney Int 38:S2-S8.
8. Feng W, Ribeiro RCJ, Wagner RL, Nguyen H, Apriletti JA, Fletterick RJ, Baxter JD, Kushner PJ and West BL (1998) Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors. Science (Wash DC) 280:1747-1749.
9. Freedman LP (1992) Anatomy of the steroid receptor zinc finger region. Endocr Rev 13:129-145.
10. Freedman LP (1999) Increasing the complexity of coactivation in nuclear receptor signaling. Cell 97:5-8.
11. Gill RK, Atkins LM, Hollis BW and Bell NH (1998) Mapping the domains of the interaction of the vitamin D receptor and steroid receptor coactivator-1. Mol Endocrinol 12:57-65.
12. Hörlein AJ, Näär AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Söderström M, Glass CK and Rosenfeld MG (1995) Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature (Lond) 377:397-404.
13. Jimenez-Lara AM and Aranda A (1999) Lysine 246 of the vitamin D receptor is crucial for ligand-dependent interaction with coactivators and transcriptional activity. J Biol Chem 274:13503-13510.
14. 3 receptor identifying C-terminal amino acids required for transcriptional activation that are functionally dissociated from hormone binding, heterodimeric DNA binding, and interaction with transcription factor IIB, in vitro. J Biol Chem 272:14592-14599.
15. 3 receptor binding site found in the rat atrial natriuretic factor promoter. Biochem Biophys Res Commun 218:882-886.
16. Kraichely DM, Collins JJ, DeLisle RK and MacDonald PN (1999) The autonomous transactivation domain in helix H3 of the vitamin D receptor is required for transactivation and coactivator interaction. J Biol Chem 274:14352-14358.
17. Leng X, Tsai S, O'Malley BW and Tsai M-J (1993) Ligand-dependent conformational changes in thyroid hormone and retinoic acid receptors are potentially enhanced by heterodimerization with retinoid X receptor. J Steroid Biochem Mol Biol 46: 643-661.
18. Levin AA, Sturzenbecker LJ, Kazmer S, Bosakowski T, Huselton C, Allenby G, Speck J, Kratzeisen C, Rosenberger M, Lovey A and Grippo JF (1992) 9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXHα. Nature (Lond) 355: 359-361.
19. Li H, Gomes PJ and Chen JD (1997) RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. Proc Natl Acad Sci USA 94:8479-8484.
20. 3 analogues and their 20-epi homologues with the vitamin D receptor. J Biol Chem 272:3336-3345.
21. II28 promotes transcriptional stimulation by activation function 2 of the retinoid X receptors. EMBO (Eur Mol Biol Organ) J 15:3093-3104.
22. Moras D and Gronemeyer H (1998) The nuclear receptor ligand-binding domain: Structure and function. Curr Opin Cell Biol 10:384-391
23. Mørk Hansen C, Mathiasen IS and Binderup L (1996) The anti-proliferative and differentiation-inducing effects of vitamin D analogues are not determined by the binding affinity for the vitamin D receptor alone. J Investig Dermatol Symp Proc 1:44-48.
24. Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W and Tjian R (1999) Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature (Lond) 398:828-832.
25. 3 receptor. Biochem J 235:561-568.
26. 3 analogues is not related to the AP-1 pathway, but related to promoter selectivity. Oncogene 11: 1853-1858.
27. 3 receptor is functionally linked to the transactivation domain 2 (AF-2). Nucleic Acids Res 24:4513-4519.
28. Neef G, Kirsch G, Schwarz K, Wiesinger H, Menrad A, Fähnrich M, Thieroff-Ekerdt R and Steinmeyer A (1995) 20-Methyl vitamin D analogues, in Proceedings of the 9th Workshop on Vitamin D, 1994, Orlando, FL (Norman AW, Bouillon R, Thomasset M eds) pp 97-98, Walter de Gruyter, Inc, Hawthorne, NY.
29. 3. J Cell Biochem 74:323-333.
30. Onate SA, Tsai SY, Tsai MJ and O'Malley BW (1995) Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science (Wash DC) 270:1354-1357.
31. 3 are associated with enhanced activation of the vitamin D receptor. J Biol Chem 270:10551-10558.
32. Quack M and Carlberg C (1999) Selective recognition of the vitamin D receptor conformations mediates promoter selectivity of vitamin D. Mol Pharmacol 55: 1077-1087.
33. Quack M, Szafranski K, Rouvinen J and Carlberg C (1998) The role of the T-box for the function of the vitamin D receptor on different types of response elements. Nucleic Acids Res 26:5372-5378.
34. Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P and Freedman LP (1999) Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature (Lond) 398: 824-828.
35. 3 response element identified in the mouse c-fos promoter. Biochem Biophys Res Commun 230:646-651.
36. Spencer TE, Jenster G, Burcin MM, Allis CD, Zhou J, Mizzen CA, McKenna NJ, Onate SA, Tsai SY, Tsai M-J and O'Malley BW (1997) Steroid receptor coactivator-1 is a histone acetyltransferase. Nature (Lond) 389:194-198.
37. Takeyama K-I, Masuhiro Y, Fuse H, Endoh H, Murayama A, Kitanaka S, Suzawa M, Yanagisawa J and Kato S (1999) Selective interaction of vitamin D receptor with transcriptional coactivators by a vitamin D analog. Mol Cell Biol 19:1049-1055.
38. Torchia J, Glass C and Rosenfeld MG (1998) Co-activators and co-repressors in the integration of transcriptional responses. Curr Opin Cell Biol 10:373-383.
39. 3 analog with two side-chains, in Proceedings of the 10th Workshop on Vitamin D 1997, Strasbourg, France (Norman AW, Bouillon R, Thomasset M eds) pp 19-21, Walter de Gruyter, Inc, Hawthorne, NY.
40. Voegel JJ, Heine MJS, Zechel C, Chambon P and Gronemeyer H (1996) TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO (Eur Mol Biol Organ) J 15:3667-3675.
41. Walters MR (1992) Newly identified actions of the vitamin D endocrine system. Endocr Rev 13:719-764.
42. Wurtz J-M, Bourguet W, Renaud J-P, Vivat V, Chambon P, Moras D and Gronemeyer H (1996) A canonical structure for the ligand-binding domain of nuclear receptors. Nat Struct Biol 3:87-94.
43. Xu J, Qiu Y, DeMayo FJ, Tsai SY, Tsai M-J and O'Malley BW (1998) Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene. Science (Wash DC) 279:1922-1925.