Crystal Structure of the Human RORα Ligand Binding Domain in Complex with Cholesterol Sulfate at 2.2 Å

Journal of Biological Chemistry

Volumn 279, Issue 14, 2004, Pages 14033-14038

  Kallen, Joerg ^a   Schlaeppi, Jean Marc ^a   Bitsch, Francis ^a   Delhon, Isabelle ^a   Fournier, Brigitte ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CRYSTAL STRUCTURE; HORMONES; HYDROPHILICITY; MUTAGENS;

LIGAND BINDING DOMAIN;

BIOCHEMISTRY;

ARGININE; CHOLESTEROL; CHOLESTEROL DERIVATIVE; CHOLESTEROL SULFATE; GLUTAMINE; HORMONE RECEPTOR; RETINOIC ACID RECEPTOR; RETINOIC ACID RELATED ORPHAN RECEPTOR ALPHA; TYROSINE; UNCLASSIFIED DRUG; WATER;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; HUMAN; HYDROGEN BOND; HYDROPHILICITY; LIGAND BINDING; MASS SPECTROMETRY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR INTRINSIC ACTIVITY;

ANIMALS; BINDING SITES; CALORIMETRY, DIFFERENTIAL SCANNING; CHOLESTEROL; CHOLESTEROL ESTERS; COS CELLS; CRYSTALLOGRAPHY; HUMANS; LIGANDS; MUTAGENESIS; POINT MUTATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TEMPERATURE; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS;

ANIMALIA;

EID: 1842639533     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400302200     Document Type: Article

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