Estrogen response elements function as allosteric modulators of estrogen receptor conformation

Molecular and Cellular Biology

Volumn 18, Issue 4, 1998, Pages 1927-1934

  Wood, Jennifer R ^a   Greene, Geoffrey L ^b   Nardulli, Ann M ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; TRANSCRIPTION FACTOR; VITELLOGENIN;

AMINO ACID SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; DNA BINDING; GENE CONTROL; GENE EXPRESSION REGULATION; HORMONAL REGULATION; HORMONE RECEPTOR INTERACTION; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; XENOPUS LAEVIS;

AMPHIBIA; REPTILIA; XENOPUS LAEVIS;

EID: 0031900850     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.4.1927     Document Type: Article

References (51)

1. Alber, T. 1993. How GCN4 binds DNA. Curr. Biol. 3:182-184.
2. Beekman, J. M., G. F. Allan, S. Y. Tsai, M.-J. Tsai, and B. O'Malley. 1993. Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain. Mol. Endocrinol. 7:1266-1274.
3. Berry, M., D. Metzger, and P. Chambon. 1990. Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen. EMBO J. 9:2811-2818.
4. Blaustein, J. 1993. Estrogen receptor immunoreactivity in rat brain: rapid effects of estradiol injection. Endocrinology 132:1218-1224.
5. Bourguet, W., M. Ruff, P. Chambon, H. Gronemeyer, and D. Moras. 1995. Crystal structural of the ligand-binding domain of the human nuclear receptor RXR-alpha. Nature 375:377-382.
6. Chang, T.-C., A. M. Nardulli, D. Lew, and D. J. Shapiro. 1992. The role of estrogen response elements in expression of the Xenopus laevis vitellogenin B1 gene. Mol. Endocrinol. 6:346-354.
7. Fawell, S., R. White, S. Hoare, M. Sydenham, M. Page, and M. Parker. 1990. Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization. Proc. Natl. Acad. Sci. USA 17:6883-6887.
8. Fawell, S. E., J. A. Lees, R. White, and M. G. Parker. 1990. Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor. Cell 60:953-962.
9. Frankel, A. D., and P. S. Kim. 1991. Modular structure of transcription factors: implications tor gene regulation. Cell 65:717-719.
10. Fujita, T., G. P. Nolan, S. Ghosh, and D. Baltimore. 1992. Independent modes of transcriptional activation by the p50 and p65 subunits of NF-KB. Genes Dev. 6:775-787.
11. Furlow, J. D., F. E. Murdoch, and J. Gorski. 1993. High affinity binding of the estrogen receptor to a DNA response element does not require homodimer formation or estrogen. J. Biol. Chem. 268:12519-12525.
12. Green, S., and P. Chambon. 1987. Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor. Nature 325:75-78.
13. Greene, G., N. Sobel, W. King, and E. Jensen. 1984. Immunochemical studies of estrogen receptors. J. Steroid Biochem. 20:51-56.
14. Hansen, J. C., and J. Gorski. 1986. Conformational transitions of the estrogen receptor monomer. J. Biol. Chem. 261:13990-13996.
15. Hard, T., E. Kellenbach, R. Boelens, B. A. Naler, K. Dahlman, L. P. Freedman, J. Carlstedt-Duke, K. R. Yamamoto, J.-A. Gustafsson, and R. Kaptein. 1990. Solution structure of the glucocorticoid receptor DNA-binding domain. Science 249:157-160.
16. Klein-Hitpass, L., G. U. Ryffel, E. Heitlinger, and A. C. B. Cato. 1988. A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor. Nucleic Acids Res. 16:647-663.
17. Klein-Hitpass, L., S. Y. Tsai, G. L. Greene, J. H. Clark, M.-J. Tsai, and B. W. O'Malley. 1989. Specific binding of estrogen receptor to the estrogen response element. Mol. Cell. Biol. 9:43-49.
18. Kuiper, G. G. J. M., E. Enmark, M. Pelto-Huikko, S. Nilsson, and J.-A. Gustafsson. 1996. Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc. Natl. Acad. Sci. USA 93:5925-5930.
19. Lefstin, J. A., J. R. Thomas, and K. R. Yamamoto. 1994. Influence of a steroid receptor DNA-binding domain on transcriptional regulatory functions. Genes Dev. 8:2842-2856.
20. Littlewood, T. D., D. C. Hancock, P. S. Danielian, M. G. Parker, and G. I. Evan. 1995. A modified oestrogen receptor ligand binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res. 23:1686-1690.
21. Luisi, B. F., W. X. Xu, Z. Otwinowski, L. P. Freedman, K. R. Yamamoto, and P. B. Sigler. 1991. Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature 352:497-505.
22. Martinez, E., and W. Wahli. 1989. Cooperative binding of estrogen receptor to imperfect estrogen-responsive DNA elements correlates with their synergistic hormone-dependent enhancer activity. EMBO J. 8:3781-3791.
23. Metzger, D., S. Ali, J.-M. Bornert, and P. Chambon. 1995. Characterization of the amino-terminal transcriptional activation function of the human estrogen receptor in animal and yeast cells. J. Biol. Chem. 270:9535-9542.
24. Montano, M. M., K. Ekena, K. D. Krueger, A. L. Keller, and B. S. Katzenellenbogen. 1996. Human estrogen receptor ligand activity inversion mutants: receptors that interpret antiestrogens as estrogens and estrogens as antiestrogens and discriminate among different antiestrogens. Mol. Endocrinol. 10:230-242.
25. Nardulli, A. M., G. L. Greene, and D. J. Shapiro. 1993. Human estrogen receptor bound to an estrogen response element bends DNA. Mol. Endocrinol. 7:331-340.
26. Nardulli, A. M., C. Grobner, and D. Cotter. 1995. Estrogen receptor-induced DNA bending: orientation of the bend and replacement of an estrogen response element with an intrinsic DNA bending sequence. Mol. Endocrinol. 9:1064-1076.
27. Nardulli, A. M., D. Lew, L. Erijman, and D. J. Shapiro. 1991. Purified estrogen receptor DNA binding domain expressed in Escherichia coli activates transcription of an estrogen-responsive promoter in cultured cells. J. Biol. Chem. 266:24070-24076.
28. Nardulli, A. M., L. E. Romine, C. Carpo, G. L. Greene, and B. Rainish. 1996. Estrogen receptor affinity and location of consensus and imperfect estrogen response elements influence transcription activation of simplified promoters Mol. Endocrinol. 10:694-704.
29. Nardulli, A. M., and D. J. Shapiro. 1992. Binding of the estrogen receptor DNA-binding domain to the estrogen response element induces DNA bending. Mol. Cell. Biol. 12:2037-2042.
30. Nunez, A.-M., M. Berry, J.-L. Imler, and P. Chambon. 1989. The 5′ flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Haras oncoprotein and the c-jun protein. EMBO J. 8:823-829.
31. Pabo, C. O., and R. T. Sauer. 1992. Transcription factors: structural families and principles of DNA recognition. Annu. Rev. Biochem. 61:1053-1095.
32. Punglikitmongkol, M., S. Green, and P. Chambon. 1988. Genomic organization of the human oestrogen receptor gene. EMBO J. 7:3385-3388.
33. Potthoff, S. J., L. E. Romine, and A. M. Nardulli. 1996. Effects of wild type and mutant estrogen receptors on DNA flexibility, DNA bending, and transcription activation. Mol. Endocrinol. 10:1095-1106.
34. Renaud, J.-P., N. Rochel, M. Ruff, V. Vivat, P. Chambon, H. Gronemeyer, and D. Moras. 1995. Crystal structure of the RAR-gamma ligand-binding domain hound to all-trans retinoic acid. Nature 378:681-689.
35. Schreiber, E., P. Matthias, M. Müller, and W. Schaffner. 1988. Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA). EMBO J. 7:4221-4229.
36. Schwabe, J. W. R., L. Chapman, J. T. Finch, and D. Rhodes. 1993. The crystal structure of the estrogen receptor DNA-binding domain hound to DNA: how receptors discriminate between their response elements. Cell 75: 567-578.
37. Schwabe, J. W. R., L. Chapman, J. T. Finch, D. Rhodes, and D. Neuhaus. 1993. DNA recognition by the oestrogen receptor: From solution to the crystal. Structure 1:187-204.
38. Schwabe, J. W. R., L. Chapman, and D. Rhodes. 1995. The oestrogen receptor recognizes an imperfectly palindromic response element through an alternative side-chain conformation. Structure 3:201-213.
39. Spolar, R. S., and M. T. Record. 1994. Coupling of local folding to sitespecific binding of proteins to DNA. Science 263:777-784.
40. Staal, A., A. J. van Wijnen, J. C. Birkenhäger, H. A. P. Pols, J. Prahl, H. DeLuca, M.-P. Gaub, J. B. Lian, G. S. Stein, J. P. T. M. van Leeuwen, and J. L. Stein. 1996. Distinct conformations of vitamin D receptor/retinoid X receptor-α heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes. Mol. Endocrinol. 10:1444-1456.
41. Starr, D. B., W. Matsui, J. R. Thomas, and K. R. Yamamoto. 1996. Intracellular receptors use a common mechanism to interpret signaling information at response elements. Genes Dev. 10:1271-1283.
42. Steitz, T. A. 1990. Structural studies of protein-nucleic acid interaction: the sources of sequence-specific binding. Q. Rev. Biophys. 23:205-280.
43. Talanian, R. V., C. J. McKnight, and P. S. Kim. 1990. Sequence-specific DNA binding by a short peptide dimer. Science 249:769-771.
44. Tan, S., and T. J. Richmond. 1990. DNA binding-induced conformational change of the yeast transcriptional activator PRTF. Cell 62:367-377.
45. Tasset, D., L. Tora, C. Fromental, E. Scheer, and P. Chambon. 1990. Distinct classes of transcriptional activating domains function by different mechanisms. Cell 62:1177-1187.
46. Tora, L., J. White, C. Brou, D. Tasset, N. Webster, E. Scheer, and P. Chambon. 1989. The human estrogen receptor has two independent non-acidic transcriptional activation functions. Cell 59:477-487.
47. Tzukerman, M. T., A. Esty, D. Santiso-Mere, P. Danielian, M. G. Parker, R. B. Stein, J. W. Pike, and D. P. McDonnell. 1994. Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. Mol. Endocrinol. 8:21-30.
48. von Hippel, P. H. 1994. Protein-DNA recognition: new perspectives and underlying themes. Science 263:769-770.
49. Wagner, R., J. Apriletti, M. McGrath, B. West, J. Baxter, and R. Fletterick. 1995. A structural role for hormone in the thyroid hormone receptor. Nature 378:690-697.
50. Walker, P., J.-E. Germond, M. Brown-Luedi, F. Givel, and W. Wahli. 1984. Sequence homologies in the region preceding the transcription initiation site of the liver estrogen-responsive vitellogenin and apo-VLDLII genes. Nucleic Acids Res. 12:8611-8626.
51. Webster, N. J. G., S. Green, J. R. Jin, and P. Chambon. 1988. The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell 54:199-207.