Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells

Journal of Biological Chemistry

Volumn 278, Issue 9, 2003, Pages 6680-6686

  Assaraf, Yehuda G ^a   Rothem, Lilah ^a   Hooijberg, Jan Hendrik ^b   Stark, Michal ^a   Ifergan, Ilan ^a   Kathmann, Ietje ^b   Dijkmans, Ben A C ^b   Peters, Godefridus J ^b   Jansen, Gerrit ^b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; FLUORESCENCE; NEGATIVE IONS; PROTEINS; TUMORS;

HOMEOSTASIS;

BIOCHEMISTRY;

EDATREXATE; FOLIC ACID; FOLINIC ACID; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; PROBENECID; VERLUKAST; CALCEIN; FLUORESCEIN DERIVATIVE; GLYCOPROTEIN P;

ANION EXCHANGE; ARTICLE; CELL METABOLISM; DRUG ACTIVITY; DRUG HYPERSENSITIVITY; DRUG TRANSPORT; GENE OVEREXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; CELL LINE; CELL MEMBRANE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; METABOLISM; MUTATION; TIME; TRANSPORT AT THE CELLULAR LEVEL; WESTERN BLOTTING;

BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CELL DIVISION; CELL LINE; CELL MEMBRANE; FLOW CYTOMETRY; FLUORESCEINS; FOLIC ACID; HUMANS; LEUCOVORIN; METHOTREXATE; MICROSCOPY, FLUORESCENCE; MUTATION; P-GLYCOPROTEIN; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0037470032     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209186200     Document Type: Article

References (38)

1. Stockstad, E. L. R. (1990) in Folic Acid Metabolism in Health and Disease (Piccianno, M. F., Stockstad, E. L. R., and Gregory, J. F., eds) pp. 1-21, Wiley-Liss, New York
2. Bertino, J. R. (1993) J. Clin. Oncol. 11, 5-14
3. Goldman, I. D. (2002) Clin. Cancer Res. 8, 4-6
4. Jansen, G. (1999) in Antifolate Drugs in Cancer Therapy (Jackman, A. L., ed) pp. 293-321, Humana Press, Totowa, NJ
5. Goldman, I. D. (1971) Ann. N. Y. Acad. Sci. 186, 400-422
6. Henderson, G. B., and Zevely, E. M. (1981) Biochem. Biophys. Res. Commun. 99, 163-169
7. Zhao, R., Gao, F., Wang, Y., Diaz, G. A., Gelb, B. D., and Goldman, I. D. (2001) J. Biol. Chem. 276, 1114-1118
8. Antony, A. C. (1992) Blood 79, 2807-2820
9. Henderson, G. B., and Strauss, B. P. (1990) Cancer Res. 50, 1709-1714
10. Sierra, E. E., Brigle, K. E., Spinella, M. J., and Goldman, I. D. (1997) Biochem. Pharmacol. 53, 223-231
11. Assaraf, Y. G., Babani, S., and Goldman, I. D. (1998) J. Biol. Chem. 273, 8106-8111
12. Dembo, M., Sirotnak, F. M., and Moccio, D. M. (1984) J. Membr. Biol. 78, 9-17
13. Henderson, G. B., Tsuji, J. M., and Kumar, H. P. (1986) Cancer Res. 46, 1633-1638
14. Borst, P., and Oude Elferink, R. (2002) Annu. Rev. Biochem. 71, 537-592
15. Renes, J., de Vries, E. G. E., Jansen, P. L. M., and Muller, M. (2000) Drug Resistance Updates 3, 287-300
16. Hooijberg, J.-H., Broxterman, H. J., Kool, M., Assaraf, Y. G., Peters, G. J., Noordhuis, P., Scheper, R. J., Borst, P., Pinedo, H. M., and Jansen, G. (1999) Cancer Res. 59, 2532-2535
17. Kool, M., van der Linden, de Haas, M., Scheffer, G. L., de Vree, J. M., Smith, A. J., Jansen, G., Peters, G. J., Ponne, N., Scheper, R. J., Elferink, R. P., Baas, F., and Borst, P. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 6914-6919
18. Zeng, H., Bain, I., J., Belinsky, M. G., and Kruh, G. D. (1999) Cancer Res. 59, 5964-5967
19. Lee, K., Klein-Szanto, A. J., and Kruh, G. D. (2000) J. Natl. Cancer Inst. 92, 1934-1940
20. Higgins, C. F. (1992) Annu. Rev. Cell Biol. 8, 67-113
21. Klein, I., Sarkadi, B., and Varadi, A. (1999) Biochim. Biophys. Acta 1461, 237-262
22. Zeng, H., Cheng, Z.-S., Belinsky, M. G., Rea, P. A., and Kruh, G. D. (2001) Cancer Res. 61, 7225-7232
23. Jansen, G., Westerhof, G. R., Jarmuszewski, M. J. A., Kathmann, I., Rijksen, G., and Schornagel, J. H. (1990) J. Biol. Chem. 265, 18272-18277
24. Drori, S., Sprecher, H., Shemer, G., Jansen, G., Goldman, I. D., and Assaraf, Y. G. (2000) Eur. J. Biochem. 267, 690-702
25. Zhao, R., Seither, R., Brigle, K. E., Sharina, I. G., Wang, P. J., and Goldman, I. D. (1997) J. Biol. Chem. 272, 21207-21212
26. Jansen, G., Mauritz, R., Drori, S., Sprecher, H., Kathmann, I., Bunni, M. A., Priest, D. G., Noordhuis, P., Schornagel, J. H., Pinedo, H. M., Peters, G. J., and Assaraf, Y. G. (1998) J. Biol. Chem. 273, 30189-30198
27. Assaraf, Y. G., and Goldman, I. D. (1997) J. Biol. Chem. 272, 17460-17466
28. Jansen, G., Kathmann, I., Rademaker, B. C., Braakhuis, B. J. M., Westerhof, G. R., Rijksen, G., and Schornagel, J. H. (1989) Cancer Res. 49, 1959-1963
29. Rosowsky, A., Lazarus, H., Yuan, G. C., Beltz, W. R., Mangini, L., Abelson, H. T., Modest, E. J., and Frei, E., III (1980) Biochem. Pharmacol. 29, 648-652
30. Drori, S., Jansen, G., Mauritz, R., Peters, G. J., and Assaraf, Y. G. (2000) J. Biol. Chem. 275, 30855-30863
31. Henderson, G. B., and Zevely, E. M. (1984) J. Biol. Chem. 259, 4558-4562
32. Versantvoort, C. H., Bagrij, T., Wright, K. A., and Twentymen, P. R. (1995) Int. J. Cancer 63, 855-862
33. Feller, N., Broxterman, H. J., Wahrer, D. C., and Pinedo, H. M. (1995) FEBS Lett. 368, 385-388
34. Gekeler, V., Ise, W., Sanders, K. H., Ulrich, W. R., and Beck, J. (1995) Biochem. Biophys. Res. Commun. 208, 345-352
35. Olson, D. P., Taylor, B. J., and Ivy, S. P. (2001) Cytometry 46, 105-113
36. Rothem, L., Ifergan, I., Kaufman, Y., Priest, D. G., Jansen, G., and Assaraf, Y. G. (2002) Biochem. J., 367, 741-750
37. Schuetz, J. D., Connely, M. C., Sun, D., Paibir, S. G., Flynn, P. M., Srinivas, R. V., Kumar, A., and Fridland, A. (1999) Nat. Med. 5, 1048-1051
38. Chen, Z.-S., Lee, K., Walther, S., Blanchard Raftogianis, R., Kuwanu, M., Zeng, H., and Kruh, G. D. (2002) Cancer Res. 62, 3144-3150