Basolateral localization and export activity of the human multidrug resistance - associated protein in polarized pig kidney cells

Journal of Clinical Investigation

Volumn 97, Issue 5, 1996, Pages 1211-1218

  Evers, Raymond ^a   Zaman, Guido J R ^a,b   Van Deemter, Liesbeth ^a   Jansen, Hans ^a   Calafat, Jero ^a   Oomen, Lauran C J M ^a   Oude Elferink, Ronald P J ^c   Borst, Piet ^a   Schinkel, Alfred H ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Glutathione S conjugate; GS X pump; Multidrug resistance; Reversal agents; Sorting

Indexed keywords

CARRIER PROTEIN; COMPLEMENTARY DNA; CYTOTOXIC AGENT; DAUNORUBICIN; GLUTATHIONE; GLUTATHIONE DERIVATIVE; GLYCOPROTEIN P; PROBENECID; SULFINPYRAZONE;

ANIMAL CELL; ARTICLE; BASOLATERAL MEMBRANE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; DRUG ACCUMULATION; KIDNEY CELL; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TARGETING;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CELL LINE; DAUNORUBICIN; DRUG RESISTANCE, MULTIPLE; GLUTATHIONE; HUMANS; KIDNEY; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; SWINE;

EID: 0029995238     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118535     Document Type: Article

References (35)

1. Gottesman, M M., and I. Pastan. 1993 Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62 385-427.
2. Cole, S.P.C., G. Bhardwaj, J H. Gerlach, J.E. Mackie, C.E. Grant, K.C. Almquist, A.J Stewart, E.U. Kurz, A.M.V. Duncan, and RG. Deeley 1992. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line Science (Wash DC). 258:1650-1654.
3. Cole, S.P.C., K E. Sparks, K., Fraser, D.W. Loe, C.E. Grant, G.M. Wilson, and R.G. Deeley. 1994. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res. 54:5902-5910.
4. Zaman, G.J.R., C.H.M. Versantvoort, J.J.M. Smit, E.W.H.M. Eijdems, M. de Haas, A.J. Smith, H.J. Broxterman, N.H. Mulder, E.G.E, de Vries, F. Baas, and P. Borst. 1994. The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc. Natl Acad. Sci. USA. 91: 8822-8826.
5. Flens, M.J., M.A Izquierdo, G.L. Scheffer, J.M. Fritz, C.J.L.M. Meijer, R.J. Scheper, and G.J.R Zaman. 1994. Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies. Cancer Res. 54:4557-4563.
6. Almquist, K.C., D.W. Loe, D.R. Hipfner, J.E. Mackie, S.P.C. Cole, and R.G. Deeley. 1995. Characterization of the Mr 190,000 multidrug resistance protein (MRP) in drug-selected and transfected human tumor cells. Cancer Res. 55:102-110.
7. Jedlitschky, G., I. Leier, U. Buchholz, M. Center, and D. Keppler. 1994. ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. Cancer Res. 54:4833-4836.
8. Müller, M., C. Meijer, G.J.R. Zaman, P. Borst, R.J. Scheper, N.H. Mulder, E.G.E, de Vries, and P.L.M. Jansen. 1994. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc Natl. Acad. Sci. USA. 91: 13033-13037.
9. Ishikawa, T. 1992. The ATP-dependent glutathione S-conjugate export pump. Trends Biochem. Sci. 17:463-468.
10. - rats. In Hepatic Transport and Bile Secretion: Physiology and Pathophysiology, N. Tavoloni, and P.D. Beik, editors. Raven Press, New York. 721-731.
11. 4 and structurally related conjugates. J. Biol. Chem. 269:27807-27810.
12. Gekeler, V., W. Ise, K.H. Sanders, W.R. Ulrich, and J. Beck. 1995. The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance. Biochem. Biophys. Res. Commun. 208:345-352.
13. Versantvoort, C.H.M., H.J. Broxterman, T. Bagrij, R.J. Scheper, and P.R. Twentyman. 1995. Regulation by glutathione of drug transport in multidrug resistant human lung tumour cell lines overexpressing MRP. Br. J. Cancer. 72:82-89.
14. Zaman, G.J.R , J. Lankelma, O. van Tellingen, J. Beijnen, H. Dekker, C. Paulusma, R.P.J. Oude Elferink, F. Baas, and P. Borst. 1995. Role of glutathione in the export of compounds by the multidrug resistance-associated protein. Proc. Natl. Acad. Sci. USA 92:7690-7694.
15. Zaman, G.J.R., C.H.M. Versantvoort, J.J M. Smit, E.W.H.M. Eijdems, M. de Haas, A.J. Smith, H.J. Broxterman, N.H. Mulder, E.G.E. de Vries, F. Baas, and P. Borst. 1993. Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines. Cancer Res. 53:1747-1750.
16. Burger, H., K. Nooter, G.J.R. Zaman, P. Sonneveld, K.E. van Wingerden, R.G. Oostrum, and G Stoter. 1994. Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias. Leukemia. 8: 990-997.
17. Cordon-Cardo, C., J.P. O'Brien, D. Casals, L. Rittman-Grauer, J.L. Biedler, M.R. Melamed, and J.R. Bertino. 1989. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Biochem. J 256:959-963.
18. Thiebaut, F., T. Tsuruo, H. Hamada, M.M. Gottesman, I. Pastan, and M.C Willingham. 1987. Cellular localization of the multidrug resistance gene product in normal human tissues. Proc. Natl. Acad. Sci. USA. 84:7735-7738.
19. Schinkel, A.H , J.J.M. Smit, O. van Tellingen, J H. Beijnen, E. Wagenaar, L. van Deemter, C.A.A.M. Mol, M A. van der Valk, E.C. RobanusMaandag, H.P.J. te Riele, et al. 1994. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77:491-502.
20. Ueda, K., N. Okamura, M. Hirai, Y. Tanigawara, T. Saeki, N. Kioka, T. Komano, and R Hori. 1992. Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J Biol Chem. 267:24248-24252.
21. Schinkel, A.H., E. Wagenaar, L. van Deemter, C.A.A.M. Mol, and P. Borst. 1995. Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J. Clin. Invest. 96:1698-1705.
22. Graham, F.L., and A.J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology. 52:456-467.
23. Schinkel, A.H., M.E.M. Roelofs, and P. Borst. 1991. Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies. Cancer Res. 51:2628-2635.
24. Schinkel, A.H., S. Kemp, M. Dollé, G. Rudenko, and E. Wagenaar. 1993. N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein. J. Biol. Chem. 268:7474-7481.
25. Oude Elferink, R.P.J., C.T.M. Bakker, and P.L.M. Jansen. 1993. Glutathione-conjugate transport by human colon adenocarcinoma cells (Caco-2 cells). Biochem. J. 290.759-764.
26. Di Virgilio, F., C. Fasolato, and H. Steinberg. 1988. Inhibitors of membrane transport system for organic anions block fura-2 excretion from PC12 and N2A cells. Biochem J. 256:959-963.
27. Cunningham, R.F., Z.H. Israili, and P G. Dayton. 1981. Clinical pharmacokinetics of probenecid. Clin Pharmacokinet. 6:135-151.
28. Gilman, A.G., A.S. Rall, A.S. Nies, and P. Taylor. 1991. The Pharmacological Basis of Therapeutics. McGraw-Hill Book Co , Singapore. 1811 pp.
29. Gottardi, C.J., and M.J. Caplan. 1993. An ion-transporting ATPase encodes multiple apical localization signals. J. Cell Biol. 121:283-293.
30. Rodriguez-Boulan, E , and S. Powell. 1992. Polarity of epithelial and neuronal cells. Annu Rev. Cell Biol. 8:395-427.
31. Matter, K., and I. Mellman. 1994. Mechanisms of cell polarity, sorting and transport in epithelial cells Curr. Opin. Cell Biol. 6:545-554.
32. Saxena, M., and G.B. Henderson. 1995. ATP-dependent efflux of 2,4-dinitrophenyl-S-glutathione. J. Biol. Chem. 270:5312-5319.
33. Oude Elferink, R.P.J., R. Ottenhof, W. Liefting, J. de Haan, and P.L.M. Jansen. 1989. Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia. J. Clin. Invest. 84:476-483.
34. Sepulveda, F.V., and J.D. Pearson. 1985. Polarity of epithelial and neuronal cells. In Tissue Culture of Epithelial Cells. M. Taub, editor. Plenum Press, New York. 87-88.
35. Ullrich, K.J. (1994). Specificity of transporters for "organic anions" and "organic cations" in the kidney. Biochim. Biophys. Acta. 1197:45-62.