-
1
-
-
0040761368
-
cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
-
Büchler M, König J, Brom M, Kartenbeck J, Spring H, Horie T, and Keppler D (1996) cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J Biol Chem 271:15091-15098.
-
(1996)
J Biol Chem
, vol.271
, pp. 15091-15098
-
-
Büchler, M.1
König, J.2
Brom, M.3
Kartenbeck, J.4
Spring, H.5
Horie, T.6
Keppler, D.7
-
2
-
-
0030906434
-
Multiplicity of biliary excretion mechanisms for irinotecan CPT-11, and its metabolites in rats
-
Chu XY, Kato Y, and Sugiyama Y (1997) Multiplicity of biliary excretion mechanisms for irinotecan CPT-11, and its metabolites in rats. Cancer Res 57:1934-1938.
-
(1997)
Cancer Res
, vol.57
, pp. 1934-1938
-
-
Chu, X.Y.1
Kato, Y.2
Sugiyama, Y.3
-
3
-
-
0026650170
-
Polarized efflux of 2′,7′-bis(2-carboxyethyl)-5(6)-carboxyfluorescein from cultured epithelial cell monolayers
-
Collington GK, Hunter J, Allen CN, Simmons NL, and Hirst BH (1992) Polarized efflux of 2′,7′-bis(2-carboxyethyl)-5(6)-carboxyfluorescein from cultured epithelial cell monolayers. Biochem Pharmacol 44:417-424.
-
(1992)
Biochem Pharmacol
, vol.44
, pp. 417-424
-
-
Collington, G.K.1
Hunter, J.2
Allen, C.N.3
Simmons, N.L.4
Hirst, B.H.5
-
4
-
-
0024346546
-
Absorption and presystemic glucuronidation of 1-naphthol in the vascularly fluorocarbon emulsion perfused rat small intestine. the influence of 1-naphthol concentration, perfusate flow and noradrenaline
-
de Vries MH, Hofman GA, Koster AS, and Noordhoek J (1989a) Absorption and presystemic glucuronidation of 1-naphthol in the vascularly fluorocarbon emulsion perfused rat small intestine. The influence of 1-naphthol concentration, perfusate flow and noradrenaline. Naunyn-Schmiedeberg's Arch Pharmacol 340:239-245.
-
(1989)
Naunyn-Schmiedeberg's Arch Pharmacol
, vol.340
, pp. 239-245
-
-
De Vries, M.H.1
Hofman, G.A.2
Koster, A.S.3
Noordhoek, J.4
-
5
-
-
0024418887
-
Hepatic, intestinal and renal transport of 1-naphthol-beta-D-glucuronide in mutant rats with hereditary-conjugated hyperbilirubinemia
-
de Vries MH, Redegeld FA, Koster AS, Noordhoek J, de Haan JG, Oude Elferink RP, and Jansen PL (1989b) Hepatic, intestinal and renal transport of 1-naphthol-beta-D-glucuronide in mutant rats with hereditary-conjugated hyperbilirubinemia. Naunyn-Schmiedeberg's Arch Pharmacol 340:588-592.
-
(1989)
Naunyn-Schmiedeberg's Arch Pharmacol
, vol.340
, pp. 588-592
-
-
De Vries, M.H.1
Redegeld, F.A.2
Koster, A.S.3
Noordhoek, J.4
De Haan, J.G.5
Oude Elferink, R.P.6
Jansen, P.L.7
-
7
-
-
0027345980
-
Structure and function of P-glycoprotein in normal liver and small intestine
-
Gatmaitan ZC and Arias IM (1993) Structure and function of P-glycoprotein in normal liver and small intestine. Adv Pharmacol 24:77-97.
-
(1993)
Adv Pharmacol
, vol.24
, pp. 77-97
-
-
Gatmaitan, Z.C.1
Arias, I.M.2
-
8
-
-
0025374695
-
Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport
-
Hyde SC Emsley P, Hartshorn MJ, Mimmack MM, Gileadi U, Pearce SR, Gallagher MP, Gill DR, Hubbard RE, and Higgins CF (1990) Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature (Lond) 346:362-365.
-
(1990)
Nature (Lond)
, vol.346
, pp. 362-365
-
-
Hyde, S.C.1
Emsley, P.2
Hartshorn, M.J.3
Mimmack, M.M.4
Gileadi, U.5
Pearce, S.R.6
Gallagher, M.P.7
Gill, D.R.8
Hubbard, R.E.9
Higgins, C.F.10
-
9
-
-
0024472768
-
2+-dependent cardiac transport system for glutathione S-conjugates. A study using rat heart sarcolemma vesicles
-
2+-dependent cardiac transport system for glutathione S-conjugates. A study using rat heart sarcolemma vesicles. J Biol Chem 264: 17343-17348.
-
(1989)
J Biol Chem
, vol.264
, pp. 17343-17348
-
-
Ishikawa, T.1
-
10
-
-
0025132673
-
ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates
-
Ishikawa T, Müller M, Klünemann C, Schaub T, and Keppler D (1990) ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates. J Biol Chem 265:19279-19286.
-
(1990)
J Biol Chem
, vol.265
, pp. 19279-19286
-
-
Ishikawa, T.1
Müller, M.2
Klünemann, C.3
Schaub, T.4
Keppler, D.5
-
11
-
-
15844416284
-
Coordinated induction of MRP/GS-X pump and γ-glutamylcysteine synthetase by heavy metals in human leukemia cells
-
Ishikawa T, Bao JJ, Yamane Y, Akimaru K, Frindrich K, Wright CD, and Kuo MT (1996) Coordinated induction of MRP/GS-X pump and γ-glutamylcysteine synthetase by heavy metals in human leukemia cells. J Biol Chem 271:14981-14988.
-
(1996)
J Biol Chem
, vol.271
, pp. 14981-14988
-
-
Ishikawa, T.1
Bao, J.J.2
Yamane, Y.3
Akimaru, K.4
Frindrich, K.5
Wright, C.D.6
Kuo, M.T.7
-
12
-
-
0030951558
-
Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR)
-
Ishizuka H, Konno K, Naganuma H, Sasahara K, Kawahara Y, Niinuma K, Suzuki H, and Sugiyama Y (1997) Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR). J Pharmacol Exp Ther 280:1304-1311.
-
(1997)
J Pharmacol Exp Ther
, vol.280
, pp. 1304-1311
-
-
Ishizuka, H.1
Konno, K.2
Naganuma, H.3
Sasahara, K.4
Kawahara, Y.5
Niinuma, K.6
Suzuki, H.7
Sugiyama, Y.8
-
13
-
-
0029880973
-
Expression of a putative ATP-binding cassette region, homologous to that in multidrug resistance-associated protein (MRP), is hereditarily defective in Eisai hyperbilirubinemic rats (EHBR)
-
Ito K, Suzuki H, Hirohashi T, Kazuhiko K, Shimizu T, and Sugiyama Y (1996) Expression of a putative ATP-binding cassette region, homologous to that in multidrug resistance-associated protein (MRP), is hereditarily defective in Eisai hyperbilirubinemic rats (EHBR). Int Hepatol Commun 4:292-299.
-
(1996)
Int Hepatol Commun
, vol.4
, pp. 292-299
-
-
Ito, K.1
Suzuki, H.2
Hirohashi, T.3
Kazuhiko, K.4
Shimizu, T.5
Sugiyama, Y.6
-
14
-
-
0031031247
-
Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR
-
Ito K, Suzuki H, Hirohashi T, Kazuhiko K, Shimizu T, and Sugiyama Y (1997) Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am J Physiol 272:G16-G22.
-
(1997)
Am J Physiol
, vol.272
-
-
Ito, K.1
Suzuki, H.2
Hirohashi, T.3
Kazuhiko, K.4
Shimizu, T.5
Sugiyama, Y.6
-
15
-
-
0031916830
-
Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver
-
Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T, and Sugiyama Y (1998) Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. J Biol Chem 273:1684-1688.
-
(1998)
J Biol Chem
, vol.273
, pp. 1684-1688
-
-
Ito, K.1
Suzuki, H.2
Hirohashi, T.3
Kume, K.4
Shimizu, T.5
Sugiyama, Y.6
-
16
-
-
0029849789
-
The canalicular conjugate export pump encoded by the cmrp/cmoat gene
-
Keppler D and Kartenbeck J (1996) The canalicular conjugate export pump encoded by the cmrp/cmoat gene. Prog Liver Dis 14:55-67.
-
(1996)
Prog Liver Dis
, vol.14
, pp. 55-67
-
-
Keppler, D.1
Kartenbeck, J.2
-
17
-
-
0031160517
-
Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver
-
Keppler D and König J (1997) Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver. FASEB J 11:509-516.
-
(1997)
FASEB J
, vol.11
, pp. 509-516
-
-
Keppler, D.1
König, J.2
-
18
-
-
0025343017
-
Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes
-
Kobayashi K, Sogame Y, Kara H, and Hayashi K (1990) Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes. J Biol Chem 265:7737-7741.
-
(1990)
J Biol Chem
, vol.265
, pp. 7737-7741
-
-
Kobayashi, K.1
Sogame, Y.2
Kara, H.3
Hayashi, K.4
-
19
-
-
0039476506
-
Glutathione transport by inside-out vesicles from human erythrocytes
-
Kondo T, Dale GL and Beutler E (1980) Glutathione transport by inside-out vesicles from human erythrocytes. Proc Natl Acad Sci USA 77:6359-6362.
-
(1980)
Proc Natl Acad Sci USA
, vol.77
, pp. 6359-6362
-
-
Kondo, T.1
Dale, G.L.2
Beutler, E.3
-
20
-
-
0030841332
-
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
-
Kool M, de Haas M, Scheffer GL, Scheper RJ, van Eijk MJ, Juijn JA, Baas F, and Borst P (1997) Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res 57:3537-3547.
-
(1997)
Cancer Res
, vol.57
, pp. 3537-3547
-
-
Kool, M.1
De Haas, M.2
Scheffer, G.L.3
Scheper, R.J.4
Van Eijk, M.J.5
Juijn, J.A.6
Baas, F.7
Borst, P.8
-
21
-
-
0029954845
-
Biology of the multidrug resistance-associated protein, MRP
-
Loe DW, Deeley RG, and Cole SP (1996) Biology of the multidrug resistance-associated protein, MRP. Eur J Cancer 32:945-957.
-
(1996)
Eur J Cancer
, vol.32
, pp. 945-957
-
-
Loe, D.W.1
Deeley, R.G.2
Cole, S.P.3
-
22
-
-
0030978107
-
Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein
-
Madon J, Eckhardt U, Gerloff T, Stieger B, and Meier PJ (1997) Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein. FEBS Lett 406:75-78.
-
(1997)
FEBS Lett
, vol.406
, pp. 75-78
-
-
Madon, J.1
Eckhardt, U.2
Gerloff, T.3
Stieger, B.4
Meier, P.J.5
-
23
-
-
0030818770
-
Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: Comparative study of S-(2,4-Dinitrophenyl)-glutathione and 6-Hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole glucuronide
-
Niinuma K, Takenaka O, Horie T, Kobayashi K, Kato Y, Suzuki H, and Sugiyama Y (1997) Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: Comparative study of S-(2,4-Dinitrophenyl)-glutathione and 6-Hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole glucuronide. J Pharmacol Exp Ther 282:866-872.
-
(1997)
J Pharmacol Exp Ther
, vol.282
, pp. 866-872
-
-
Niinuma, K.1
Takenaka, O.2
Horie, T.3
Kobayashi, K.4
Kato, Y.5
Suzuki, H.6
Sugiyama, Y.7
-
25
-
-
0028113285
-
Glutathione S-conjugate transport by cultured human cells
-
Olive C and Board P (1994) Glutathione S-conjugate transport by cultured human cells. Biochim Biophys Acta 1224:264-268.
-
(1994)
Biochim Biophys Acta
, vol.1224
, pp. 264-268
-
-
Olive, C.1
Board, P.2
-
26
-
-
0027480292
-
Glutathione-conjugate transport by human colon adenocarcinoma cells (Caco-2 cells)
-
Oude Elferink RP, Bakker CT, and Jansen PL (1993) Glutathione-conjugate transport by human colon adenocarcinoma cells (Caco-2 cells). Biochem J 290:759-764.
-
(1993)
Biochem J
, vol.290
, pp. 759-764
-
-
Oude Elferink, R.P.1
Bakker, C.T.2
Jansen, P.L.3
-
27
-
-
0029082150
-
Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport
-
Oude Elferink RP, Meijer DK, Kuipers F, Jansen PL, Groen AK, and Groothuis, GM (1995) Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport. Biochim Biophys Acta 1241:215-268.
-
(1995)
Biochim Biophys Acta
, vol.1241
, pp. 215-268
-
-
Oude Elferink, R.P.1
Meijer, D.K.2
Kuipers, F.3
Jansen, P.L.4
Groen, A.K.5
Groothuis, G.M.6
-
28
-
-
0029981430
-
Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
-
Paulusma CC, Bosma PJ, Zaman GJ, Bakker CT, Otter M, Scheffer GL, Scheper RJ, Borst P, and Oude Elferink RP (1996) Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science (Washington DC) 271: 1126-1128.
-
(1996)
Science (Washington DC)
, vol.271
, pp. 1126-1128
-
-
Paulusma, C.C.1
Bosma, P.J.2
Zaman, G.J.3
Bakker, C.T.4
Otter, M.5
Scheffer, G.L.6
Scheper, R.J.7
Borst, P.8
Oude Elferink, R.P.9
-
29
-
-
85034892163
-
Glutathione S-transferase, cytochrome P450 and uridine 5′-diphosphate-glucuronosyltransferase in human small intestine and liver
-
Peters WH, Nagengast FM, and van Tongeren JH (1989) Glutathione S-transferase, cytochrome P450 and uridine 5′-diphosphate-glucuronosyltransferase in human small intestine and liver. Gastroenterology 96:783-789.
-
(1989)
Gastroenterology
, vol.96
, pp. 783-789
-
-
Peters, W.H.1
Nagengast, F.M.2
Van Tongeren, J.H.3
-
30
-
-
0027382061
-
Kinetic analysis of hepatobiliary transport of organic anions in Eisai hyperbilirubinemic mutant rats
-
Sathirakul K, Suzuki H, Yasuda K, Hanano M, Tagaya O, Horie T, and Sugiyama Y (1993) Kinetic analysis of hepatobiliary transport of organic anions in Eisai hyperbilirubinemic mutant rats. J Pharmacol Exp Ther 265:1301-1312.
-
(1993)
J Pharmacol Exp Ther
, vol.265
, pp. 1301-1312
-
-
Sathirakul, K.1
Suzuki, H.2
Yasuda, K.3
Hanano, M.4
Tagaya, O.5
Horie, T.6
Sugiyama, Y.7
-
31
-
-
0028103708
-
Multiple transport systems for organic anions across the bile canalicular membrane
-
Sathirakul K, Suzuki H, Yamada T, Hanano M, and Sugiyama Y (1994) Multiple transport systems for organic anions across the bile canalicular membrane. J Pharmacol Exp Ther 268:65-73.
-
(1994)
J Pharmacol Exp Ther
, vol.268
, pp. 65-73
-
-
Sathirakul, K.1
Suzuki, H.2
Yamada, T.3
Hanano, M.4
Sugiyama, Y.5
-
32
-
-
0028229150
-
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
-
Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter E, Mol CA, van der Valk MA, Robanus-Maandag EC, te Riele HP, BermsAJM, and Borst P (1994) Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77:491-502.
-
(1994)
Cell
, vol.77
, pp. 491-502
-
-
Schinkel, A.H.1
Smit, J.J.2
Van Tellingen, O.3
Beijnen, J.H.4
Wagenaar, E.5
Van Deemter, E.6
Mol, C.A.7
Van Der Valk, M.A.8
Robanus-Maandag, E.C.9
Te Riele, H.P.10
Berms, A.J.M.11
Borst, P.12
-
33
-
-
0027299120
-
Thorgeirsson. Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates
-
Schrenk D, Gant TW, Preisegger KH, Silverman JA, Marino PA, and Thorgeirsson SS (1993) Thorgeirsson. Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates. Hepatology 17:854-860.
-
(1993)
Hepatology
, vol.17
, pp. 854-860
-
-
Schrenk, D.1
Gant, T.W.2
Preisegger, K.H.3
Silverman, J.A.4
Marino, P.A.5
Thorgeirsson, S.S.6
-
35
-
-
0030957234
-
Hepatobiliary transport mechanism for the cyclopentapeptide endothelin antagonist BQ-123
-
Shin H, Kato Y, Yamada T, Niinuma K, Hisaka A, and Sugiyama Y (1997) Hepatobiliary transport mechanism for the cyclopentapeptide endothelin antagonist BQ-123. Am J Physiol 272:G979-G986.
-
(1997)
Am J Physiol
, vol.272
-
-
Shin, H.1
Kato, Y.2
Yamada, T.3
Niinuma, K.4
Hisaka, A.5
Sugiyama, Y.6
-
36
-
-
0343554785
-
Role of efflux transport across the blood-brain barrier and blood-cerebrospinal fluid barrier on the disposition of xenobiotics in the central nervous system
-
Suzuki H, Terasaki T, and Sugiyama Y (1997) Role of efflux transport across the blood-brain barrier and blood-cerebrospinal fluid barrier on the disposition of xenobiotics in the central nervous system. Adv Drug Deliv Rev 25:257-284.
-
(1997)
Adv Drug Deliv Rev
, vol.25
, pp. 257-284
-
-
Suzuki, H.1
Terasaki, T.2
Sugiyama, Y.3
-
37
-
-
0029582975
-
Kinetic analysis of hepatobiliary transport for conjugated metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugated hyperbilirubinemia
-
Takenaka O, Horie T, Kobayashi K, Suzuki H, and Sugiyama Y (1995a) Kinetic analysis of hepatobiliary transport for conjugated metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugated hyperbilirubinemia. Pharm Res (NY) 12:1746-1755.
-
(1995)
Pharm Res (NY)
, vol.12
, pp. 1746-1755
-
-
Takenaka, O.1
Horie, T.2
Kobayashi, K.3
Suzuki, H.4
Sugiyama, Y.5
-
38
-
-
0029026940
-
Different biliary excretion systems for glucuronide and sulfate of a model compound; study using Eisai hyperbilirubinemic rats
-
Takenaka O, Horie T, Suzuki H, and Sugiyama Y (1995b) Different biliary excretion systems for glucuronide and sulfate of a model compound; study using Eisai hyperbilirubinemic rats. J Pharmacol Exp Ther 274:1362-1369.
-
(1995)
J Pharmacol Exp Ther
, vol.274
, pp. 1362-1369
-
-
Takenaka, O.1
Horie, T.2
Suzuki, H.3
Sugiyama, Y.4
-
39
-
-
0030963906
-
The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis
-
Trauner M, Arrese M, Soroka CJ, Ananthanarayanan M, Koeppel TA, Schlosser SF, Suchy FJ, Keppler D, and Boyer JL (1997) The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 113:255-264.
-
(1997)
Gastroenterology
, vol.113
, pp. 255-264
-
-
Trauner, M.1
Arrese, M.2
Soroka, C.J.3
Ananthanarayanan, M.4
Koeppel, T.A.5
Schlosser, S.F.6
Suchy, F.J.7
Keppler, D.8
Boyer, J.L.9
-
40
-
-
0029926676
-
Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics
-
Yamazaki M, Suzuki H, and Sugiyama Y (1996) Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics. Pharm Res (NY) 13:497-513.
-
(1996)
Pharm Res (NY)
, vol.13
, pp. 497-513
-
-
Yamazaki, M.1
Suzuki, H.2
Sugiyama, Y.3
-
41
-
-
0030862073
-
Biliary excretion of pravastatin in rats: Contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter
-
Yamazaki M, Akiyama S, Niinuma K, Nishigaki R, and Sugiyama Y (1997) Biliary excretion of pravastatin in rats: contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter. Drug Metab Dispos 25:1123-1129.
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 1123-1129
-
-
Yamazaki, M.1
Akiyama, S.2
Niinuma, K.3
Nishigaki, R.4
Sugiyama, Y.5
|