Mutation of a Single Conserved Tryptophan in Multidrug Resistance Protein 1 (MRP1/ABCC1) Results in Loss of Drug Resistance and Selective Loss of Organic Anion Transport

Journal of Biological Chemistry

Volumn 276, Issue 19, 2001, Pages 15616-15624

  Ito, Ken Ichi ^b   Olsen, Sharon L ^b   Qiu, Wei ^b   Deeley, Roger G ^b   Cole, Susan P C ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; BIOLOGICAL MEMBRANES; CELLS; DNA; MICROSCOPIC EXAMINATION; NEGATIVE IONS; POTASSIUM COMPOUNDS; SODIUM COMPOUNDS;

CHEMOTHERAPEUTIC AGENTS;

PROTEINS;

ABC TRANSPORTER; ALANINE; ANION; ANTIMONY TARTRATE; ARSENITE SODIUM; CYSTEINE; DAUNORUBICIN; DOXORUBICIN; EPIPODOPHYLLOTOXIN; ESTRADIOL 17 GLUCURONIDE; ETOPOSIDE; GLUTATHIONE; GREEN FLUORESCENT PROTEIN; LEUKOTRIENE C4; MULTIDRUG RESISTANCE PROTEIN 1; PHENYLALANINE; TRYPTOPHAN; TYROSINE; VERAPAMIL; VINCRISTINE; ARSENOUS ACID DERIVATIVE; GLUCURONIDE; HYBRID PROTEIN; MULTIDRUG RESISTANCE PROTEIN; PHOTOPROTEIN; SODIUM DERIVATIVE;

AMINO ACID SUBSTITUTION; ANION TRANSPORT; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG RESISTANCE; ENZYME SPECIFICITY; EUKARYOTE; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; MEMBRANE VESICLE; MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; AMINO ACID SEQUENCE; BINDING SITE; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; GENETICS; KINETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; MULTIDRUG RESISTANCE; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; REPORTER GENE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; TRANSPORT AT THE CELLULAR LEVEL;

EUKARYOTA; VINCA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARSENITES; ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; BIOLOGICAL TRANSPORT; CELL LINE; CELL SURVIVAL; CLONING, MOLECULAR; CONSERVED SEQUENCE; DRUG RESISTANCE, MULTIPLE; GENES, REPORTER; GLUCURONIDES; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; KINETICS; LUMINESCENT PROTEINS; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM COMPOUNDS; TRANSFECTION; TRYPTOPHAN; VINCRISTINE;

EID: 0035844142     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011246200     Document Type: Article

References (41)

1. Cole, S. P. C., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M. V., and Deeley, R. G. (1992) Science 258, 1650-1654
2. Hipfner, D. R., Deeley, R. G., and Cole, S. P. C. (1999) Biochim. Biophys. Acta 1461, 359-376
3. Borst, P., Evers, R., Kool, M., and Wijnholds, J. (1999) Biochim. Biophys. Acta 1461, 347-357
4. Cole, S. P. C., Sparks, K. E., Fraser, K., Loe, D. W., Grant, C. E., Wilson, G. M., and Deeley, R. G. (1994) Cancer Res. 54, 5902-5910
5. Konig, J., Nies, A. T., Cui, Y., Leier, I., and Keppler, D. (1999) Biochim. Biophys. Acta 1461, 377-394
6. Kool, M., van der Linden, M., de Haas, M., Scheffer, G. L., de Vree, J. M. L., Smith, A. J., Jansen, G., Peters, G. J., Ponne, N., Scheper, R. J., Oude Elferink, R. P. J., Baas, F., and Borst, P. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 6914-6919
7. Hipfner, D. R., Almquist, K. C., Leslie, E. M., Gerlach, J. H., Grant, C. E., Deeley, R. G., and Cole, S. P. C. (1997) J. Biol. Chem. 272, 23623-23630
8. Cui, Y., Konig, J., Buchholz, U., Spring, H., Leier, I., and Keppler, D. (1999) Mol. Pharmacol. 55, 929-937
9. Hirohashi, T., Suzuki, H., and Sugiyama, Y. (1999) J. Biol. Chem. 274, 15181-15185
10. Bakos, E., Evers, R., Sinkule, J. A., Varadi, A., Borst, P., and Sarkadi, B. (2000) Mol. Pharmacol. 57, 760-768
11. Taniguchi, K., Wada, M., Kohno, K., Nakamura, T., Kawabe, T., Kawakami, M., Kagotani, K., Okumura, K., Akiyama, S., and Kuwano, M. (1996) Cancer Res. 56, 4124-4129
12. Mao, Q., Deeley, R. G., and Cole, S. P. C. (2000) J. Biol. Chem. 275, 34165-34172
13. Loe, D. W., Almquist, K. C., Deeley, R. G., and Cole, S. P. C. (1996) J. Biol. Chem. 271, 9675-9682
14. Loe, D. W., Stewart, R. K., Massey, T. E., Deeley, R. G., and Cole, S. P. C. (1997) Mol. Pharmacol. 51, 1034-1041
15. Renes, J., de Vries, E. G. E., Nienhuis, E. F., Jansen, P. L. M., and Muller, M. (1999) Br. J. Pharmacol. 126, 681-688
16. Loe, D. W., Deeley, R. G., and Cole, S. P. C. (1998) Cancer Res. 58, 5130-5136
17. Loe, D. W., Deeley, R. G., and Cole, S. P. C. (2000) J. Pharmacol. Exp. Ther. 293, 530-538
18. Hooijberg, J. H., Broxterman, H. J., Heijn, M., Fles, D. L. A., Lankelma, J., and Pinedo, H. M. (1997) FEBS Lett. 413, 344-348
19. Zhang, D., Cole, S. P. C., and Deeley, R. G. (2001) J. Biol. Chem. 276, 13231-13239
20. Zheleznova, E. E., Markham, P. N., Edgar, R., Bibi, E., Neyfakh, A. A., and Brennan, R. G. (2000) Trends Biochem. Sci. 25, 39-43
21. Grant, C. E., Valdimarsson, G., Hipfner, D. R., Almquist, K. C., Cole, S. P. C., and Deeley, R. G. (1994) Cancer Res. 54, 357-361
22. Hipfner, D. R., Mao, Q., Qiu, W., Leslie, E. M., Deeley, R. G., and Cole, S. P. C. (1999) J. Biol. Chem. 274, 15420-15426
23. Hipfner, D. R., Almquist, K. C., Stride, B. D., Deeley, R. G., and Cole, S. P. C. (1996) Cancer Res. 56, 3307-3314
24. Cole, S. P. C. (1990) Cancer Chemother. Pharmacol. 26, 250-256
25. Cole, S. P. C., Chanda, E. R., Dicke, F. P., Gerlach, J. H., and Mirski, S. E. L. (1991) Cancer Res. 51, 3345-3352
26. Loe, D. W., Almquist, K. C., Cole, S. P. C., and Deeley, R. G. (1996) J. Biol. Chem. 271, 9683-9689
27. Loe, D. W., Oleschuk, C. J., Deeley, R. G., and Cole, S. P. C. (2000) Biochem. Biophys. Res. Commun. 275, 795-803
28. Stride, B. D., Grant, C. E., Loe, D. W., Hipfner, D. R., Cole, S. P. C., and Deeley, R. G. (1997) Mol. Pharmacol. 52, 344-353
29. Jedlitschky, G., Leier, I., Buchholz, U., Center, M., and Keppler, D. (1994) Cancer Res. 54, 4833-4836
30. Keppler, D., Leier, I., and Jedlitschky, G. (1997) Biol. Chem. Hopper-Seyler 378, 787-791
31. Suzuki, H., and Sugiyama, Y. (1998) Semin. Liver Dis. 18, 359-376
32. Gao, M., Yamazaki, M., Loe, D. W., Westlake, C. J., Grant, C. E., Cole, S. P. C., and Deeley, R. G. (1998) J. Biol. Chem. 273, 10733-10740
33. Bakos, E., Evers, R., Szakacs, G., Tusnady, G. E., Welker, E., Szabo, K., de Haas, M., van Deemter, L., Borst, P., Varadi, A., and Sarkadi, B. (1998) J. Biol. Chem. 273, 32167-32175
34. Ito, K., Leslie, E. M., Weigl, K. E., Oleschuk, C. J., Deeley, R. G., and Cole, S. P. C. (2000) Proc. Am. Assoc. Cancer Res. 41, 4297 (abstr.)
35. Tusnady, G. E., Bakos, E., Varadi, A., and Sarkadi, B. (1997) FEBS Lett. 402, 1-3
36. Hafkemeyer, P., Dey, S., Ambudkar, S. V., Hrycyna, C. A., Pastan, I., and Gottesman, M. M. (1998) Biochemistry 37, 16400-16409
37. Zhang, X., Collins, K. I., and Greenberger, L. M. (1995) J. Biol. Chem. 270, 5441-5448
38. Loo, T. W., and Clarke, D. M. (1993) J. Biol. Chem. 268, 19965-19972
39. Gottesman, M. M., Pastan, I., and Ambudkar, S. V. (1996) Curr. Biol. 6, 610-617
40. Ryu, S., Kawabe, T., Nada, S., and Yamaguchi, A. (2000) J. Biol. Chem. 275, 39617-39624
41. Ito, K., Suzuki, H., and Sugiyama, Y. (2000) Proc. Am. Assoc. Cancer Res. 41, 674 (abstr.)