Identification of the biosynthetic leukotriene C4 export pump in murine mastocytoma cells as a homolog of the multidrug-resistance protein

European Journal of Biochemistry

Volumn 242, Issue 2, 1996, Pages 201-205

  Leier, Inka ^a   Jedlitschky, Gabriele ^a   Büchler, Markus ^a   Buchholz, Ulrike ^a   Brom, Manuela ^a   Keppler, Dietrich ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

ATP dependent export; Conjugate export pump; Glutathione conjugate; Leukotriene C4; Multidrug resistance protein

Indexed keywords

LEUKOTRIENE C4; MEMBRANE PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MASTOCYTOMA; MEMBRANE BINDING; MOLECULAR WEIGHT; MULTIDRUG RESISTANCE; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ANIMALIA; MURINAE;

EID: 0029806319     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.0201r.x     Document Type: Article

References (28)

1. Schaub, T., Ishikawa, T. & Keppler, D. (1991) ATP-dependent export of leukotrienes by mastocytoma cells, FEBS Lett. 279, 83-86.
2. 4 export carrier in mastocytoma cells, Eur. J. Biochem. 220, 599-606.
3. Jedlitschky, G., Leier, I., Buchholz, U., Center, M. & Keppler, D. (1994) ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein, Cancer Res. 54, 4833-4836.
4. 4 and structurally related conjugates, J. Biol. Chem. 269, 27807-27810.
5. Müller, M., Meijer, C., Zaman, G. J. R., Borst, P., Scheper, R. J., Mulder, N. H., De Vries, E. G. E. & Jansen, P. L. M. (1994) Overexpression of the gene encoding the multidrug resistance associated protein results in increased ATP-dependent glutathione S-conjugate transport, Proc. Natl Acad. Sci. USA 91, 13033-13037.
6. Cole, S. P. C., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M. V. & Deeley, R. G. (1992) Overexpression of a transporter gene in a multidrug resistant human lung cancer cell line, Science 258, 1650-1654.
7. Krishnamachary, N. & Center, M. S. (1993) The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein, Cancer Res. 53, 3658-3661.
8. Zaman, G. J. R., Versantvoort, C. H. M., Smit, J. J. M., Eijdems, E. W. H. M., de Haas, M., Smith, A. J., Broxterman, H. J., Mulder, N. H., de Vries, E. G. E., Baas, F. & Borst, P. (1993) Analysis of the expression of MRP, the gene for a putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines, Cancer Res. 53, 1747-1750.
9. Thomas, G. A., Barrand, M. A., Steward, S., Rabbitts, P. H., Williams, E. D. & Twentyman, P. R. (1994) Expression of the multidrug resistance-associated protein (MRP) gene in human lung tumours and normal tissue as determined by in situ hybridisation, Eur. J. Cancer 30A, 1705-1709.
10. Grant, C. E., Valdimarsson, G., Hipfner, D. R., Almquist, K. C., Cole, S. P. C. & Deeley, R. G. (1994) Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs, Cancer Res. 54, 357-361.
11. Leier, I., Jedlitschky, G., Buchholz, U., Center, M., Cole, S. P. C., Deeley, R. G. & Keppler, D. (1996) ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump, Biochem. J. 314, 433-437.
12. Jedlitschky, G., Leier, I., Buchholz, U., Barnouin, K., Kurz, G. & Keppler, D. (1996) Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump, Cancer Res. 56, 988-994.
13. Loe, D. W., Almquist, K. C., Cole, S. P. C. & Deeley, R. G. (1996) ATP-dependent 17β-estradiol 17-(β-D-glucuronide) transport by multidrug resistance protein (MRP), J. Biol. Chem. 271, 9683-9689.
14. 4 and chemotherapeutic agents in membrane vesicles, J. Biol. Chem. 271, 9675-9682.
15. Slapak, C. A., Fracasso, P. M., Martell, R. L., Toppmeyer, D. L., Lecerf, J.-M. & Levy, S. B. (1994) Overexpression of the multidrug resistance-associated protein (MRP) gene in vincristine but not doxorubicin-selected multidrug-resistant murine erythroleukemia cells, Cancer Res. 54, 5607-5613.
16. Lorico, A., Rappa, G., Srimatkandada, S., Catapano, C. V., Fernandez, D. J., Germino, J. F. & Sartorelli, A. C. (1995) Increased rate of adenosine triphosphate-dependent etoposide (VP-16) efflux in a murine leukemia cell line overexpressing the multidrug resistance-associated protein (MRP) gene, Cancer Res. 55, 4352-4360.
17. Büchler, M., König, J., Brom, M., Kartenbeck, J., Spring, H., Horie, T. & Keppler, D. (1996) cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats, J. Biol. Chem. 271, 15091-15098.
18. Paulusma, C. C., Bosma, P. J., Zaman, G. J. R., Bakker, C. T. M., Otter, M., Scheffer, G. L., Scheper, R. J., Borst, P. & Oude Elferink, R. P. J. (1996) Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene, Science 271, 1126-1128.
19. Krishnamachary, N., Ma, L., Zheng, L., Safa, A. R. & Center, M. S. (1994) Analysis of MRP gene expression and function in HL60 cells isolated for resistance to adriamycin, Oncology Res. 6, 119-127.
20. Hipfner, D. R., Gauldie, S. D., Deeley, R. G. & Cole, S. P. C. (1994) Detection of the M, 190,000 multidrug resistance protein. MRP, with monoclonal antibodies, Cancer Res. 54, 5788-5792.
21. Hültner, L., Szötz, H., Welle, M., van Snick, L., Moeller, J. & Dormer, P. (1989) Mouse bone marrow-derived IL-3-dependent mast cells and autonomous sublines produce Il-6, Immunology 67, 408-413.
22. McGrath, T., Latoud, C., Arnold, S. T., Safa, A. R., Felsted, R. L. & Center, M. S. (1989) Mechanisms of multidrug resistance in HL60 cells. Analysis of resistance associated membrane proteins and levels of mdr gene expression, Biochem. Pharmacol. 38, 3611-3619.
23. Marquardt, D., McCrone, S. & Center, M. S. (1990) Mechanisms of multidrug resistance in HL60 cells: detection of resistance-associated proteins with antibodies against synthetic peptides that correspond to the deduced sequence of P-glycoprotein, Cancer Res. 50, 1426-1430.
24. Falk, E., Müller, M., Huber, M., Keppler, D. & Kurz, G. (1989) Direct photoaffinity labeling of leukotriene binding sites, Eur. J. Biochem. 186, 741-747.
25. Towbin, J., Staehelin, T. & Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications, Proc. Natl Acad. Sci. USA 76, 4350-4354.
26. Mayer, R., Kartenbeck, J., Büchler, M., Jedlitschky, G., Leier, I. & Keppler, D. (1995) Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. J. Cell Biol. 131, 137-150.
27. Stride, B. D., Valdimarsson, G., Gerlach, J. H., Wilson, G. M., Cole, S. P. C. & Deeley, R. G. (1996) Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter, Mol. Pharmacol. 49, 962-971.
28. Flens, M. J., Zaman, G. J. R., van der Valk, P., Izquierdo, M. A., Schroeijers, A. B., Scheffer, G. L., van der Groep, P., de Haas, M., Meijer, C. J. L. M. & Scheper, R. J. (1996) Tissue distribution of the multidrug resistance protein, Am. J. Pathol. 148, 1237-1247.