Biliary excretion of 17β-estradiol 17β-D-glucuronide is predominantly mediated by cMOAT/MRP2

Pharmaceutical Research

Volumn 17, Issue 5, 2000, Pages 546-552

  Morikawa, Akiko ^a   Goto, Yasumasa ^a   Suzuki, Hiroshi ^a,b   Hirohashi, Tomoko ^a   Sugiyama, Yuichi ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

17 estradiol 17 D glucuronide; Biliary excretion; cMOAT MRP2; P glycoprotein

Indexed keywords

2,4 DINITROPHENOL; ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; ESTRADIOL 17 GLUCURONIDE; GLUTATHIONE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2; TRITIUM; UNCLASSIFIED DRUG; VALSPODAR; VERAPAMIL; ANION TRANSPORT PROTEIN; DRUG DERIVATIVE; ESTRADIOL; ESTRADIOL 17 BETA GLUCURONIDE; ESTRADIOL-17 BETA-GLUCURONIDE; S (2,4 DINITROPHENYL)GLUTATHIONE; S-(2,4-DINITROPHENYL)GLUTATHIONE;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BILIARY EXCRETION; CHOLESTASIS; CONTROLLED STUDY; DRUG CLEARANCE; DRUG EXCRETION; DRUG TRANSPORT; HYPERBILIRUBINEMIA; IN VIVO STUDY; INTRAHEPATIC BILE DUCT; MALE; MEMBRANE VESICLE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RAT; THIN LAYER CHROMATOGRAPHY; URINARY EXCRETION; ANIMAL; BILE; CELL MEMBRANE; GENETICS; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; ANION TRANSPORT PROTEINS; BILE; BILE CANALICULI; CARRIER PROTEINS; CELL MEMBRANE; CHROMATOGRAPHY, THIN LAYER; ESTRADIOL; GLUTATHIONE; HYPERBILIRUBINEMIA; INJECTIONS, INTRAVENOUS; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033623722     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026412915168     Document Type: Article

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