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Volumn 56, Issue 6, 1996, Pages 1309-1314

Pharmacokinetic modulation of irinotecan and metabolites by cyclosporin A

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; CYCLOSPORIN A; DRUG METABOLITE; GLYCOPROTEIN P; IRINOTECAN;

EID: 0029876561     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (89)

References (43)
  • 2
    • 0025858296 scopus 로고
    • Identification of the metabolites of irinotecan, a new derivative of camptothecin, in rat bile and its biliary excretion
    • Atsumi, R., Suzuki, W., and Hakasui, H. Identification of the metabolites of irinotecan, a new derivative of camptothecin, in rat bile and its biliary excretion. Xenobiotica, 21: 1159-1169, 1991
    • (1991) Xenobiotica , vol.21 , pp. 1159-1169
    • Atsumi, R.1    Suzuki, W.2    Hakasui, H.3
  • 3
    • 0025996996 scopus 로고
    • Intracellular roles of SN-38, a metabolite of ehe camptothecin derivative CPT-11, in the anti-tumor effect of CPT-11
    • Kawato, Y., Aonuma, M., Hirota, Y., Kuga, H , and Sato, K Intracellular roles of SN-38, a metabolite of ehe camptothecin derivative CPT-11, in the anti-tumor effect of CPT-11 Cancer Res., 51: 4187-4191, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 4187-4191
    • Kawato, Y.1    Aonuma, M.2    Hirota, Y.3    Kuga, H.4    Sato, K.5
  • 4
    • 0028022585 scopus 로고
    • Metabolic fate of innotecan in humans, correlation of glucuronidation with diarrhea
    • Gupta, E., Lestingi, T. M., Mick, R., Ramirez, J., Vokes, E E., and Ratain, M. J. Metabolic fate of innotecan in humans, correlation of glucuronidation with diarrhea. Cancer Res., 54: 3723-3725, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 3723-3725
    • Gupta, E.1    Lestingi, T.M.2    Mick, R.3    Ramirez, J.4    Vokes, E.E.5    Ratain, M.J.6
  • 5
    • 0027242140 scopus 로고
    • Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and blood plasma of athymic mice following intraperitoneal administration of CPT-11
    • Araki, E., Ishikawa, M , Iigo, I , Koide, T., Itabashi, M., and Hoshi, A. Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and blood plasma of athymic mice following intraperitoneal administration of CPT-11. Jpn. J. Cancer Res., 84: 697-702, 1993.
    • (1993) Jpn. J. Cancer Res. , vol.84 , pp. 697-702
    • Araki, E.1    Ishikawa, M.2    Iigo, I.3    Koide, T.4    Itabashi, M.5    Hoshi, A.6
  • 7
    • 0025342506 scopus 로고
    • Nonlinear pharmacokinencs of CPT-11 in rats
    • Kaneda, N., and Yokokura, T. Nonlinear pharmacokinencs of CPT-11 in rats. Cancer Res , 50: 1721-1725, 1990.
    • (1990) Cancer Res , vol.50 , pp. 1721-1725
    • Kaneda, N.1    Yokokura, T.2
  • 9
    • 0027933519 scopus 로고
    • Phase I and pharmacokinetic study of the camptothecin derivative irinotecan administered on a weekly schedule in cancer patients
    • de Forni, M., Bugat, R., Chabot, G. G., Culine, S., Extra, J-M., Gouyette, A., Madelaine, I , Marty, M E., and Mathieu-Boue, A. Phase I and pharmacokinetic study of the camptothecin derivative irinotecan administered on a weekly schedule in cancer patients Cancer Res , 54: 4347-4354, 1994.
    • (1994) Cancer Res , vol.54 , pp. 4347-4354
    • De Forni, M.1    Bugat, R.2    Chabot, G.G.3    Culine, S.4    Extra, J.-M.5    Gouyette, A.6    Madelaine, I.7    Marty, M.E.8    Mathieu-Boue, A.9
  • 11
    • 0021233529 scopus 로고
    • Mechanisms of bile formation, hepatic uptake, and biliary excretion
    • Klaassen, C D , and Watkins, J. B , III Mechanisms of bile formation, hepatic uptake, and biliary excretion Pharmacol. Rev., 36: 1-67, 1984
    • (1984) Pharmacol. Rev. , vol.36 , pp. 1-67
    • Klaassen, C.D.1    Watkins III, J.B.2
  • 12
    • 0023575785 scopus 로고
    • Cyclosporine-induced cholestasis, inhibition of bile acid secretion is caused by the parental molecule
    • Le Thai, B., Dumont, A., Michel, A., Erlinger, S., and Haussin, D. Cyclosporine-induced cholestasis, inhibition of bile acid secretion is caused by the parental molecule Transplant. Proc., 19: 4149-4151, 1987.
    • (1987) Transplant. Proc. , vol.19 , pp. 4149-4151
    • Le Thai, B.1    Dumont, A.2    Michel, A.3    Erlinger, S.4    Haussin, D.5
  • 13
    • 0023684797 scopus 로고
    • Cholestatic effect of cyclosporine in the rat, an inhibition of bile acid secretion
    • Baltimore
    • Le Thai, B., Dumont, M., Michel, A , Erlinger, S., and Houssin, D Cholestatic effect of cyclosporine in the rat, an inhibition of bile acid secretion Transplantation (Baltimore), 46: 510-512, 1988
    • (1988) Transplantation , vol.46 , pp. 510-512
    • Le Thai, B.1    Dumont, M.2    Michel, A.3    Erlinger, S.4    Houssin, D.5
  • 14
    • 0023950559 scopus 로고
    • The mechanism of cyclosporine-induced cholestasis in the rat
    • Stone, B., Warty, V., Dindzans, V., and Van Thiel, D. The mechanism of cyclosporine-induced cholestasis in the rat. Transplant. Proc., 20: 841-844, 1988.
    • (1988) Transplant. Proc. , vol.20 , pp. 841-844
    • Stone, B.1    Warty, V.2    Dindzans, V.3    Van Thiel, D.4
  • 15
    • 0024432823 scopus 로고
    • Identification of the multidrug resistance-related P-glycoprotein as a cyclospotine binding protein
    • Foxwell, B. M J., Mackie, A , Ling, V., and Ryffel, B. Identification of the multidrug resistance-related P-glycoprotein as a cyclospotine binding protein. Mol. Pharmacol., 36: 543-546, 1989
    • (1989) Mol. Pharmacol. , vol.36 , pp. 543-546
    • Foxwell, B.M.J.1    Mackie, A.2    Ling, V.3    Ryffel, B.4
  • 16
    • 0027418815 scopus 로고
    • Human P-glycoprotein transports cyclosporin A and FK 506
    • Saeki, T., Ueda, K., Tanigawara, Y , Hori, R., and Komano, T. Human P-glycoprotein transports cyclosporin A and FK 506 J Biol. Chem., 268: 6077-6080, 1993.
    • (1993) J Biol. Chem. , vol.268 , pp. 6077-6080
    • Saeki, T.1    Ueda, K.2    Tanigawara, Y.3    Hori, R.4    Komano, T.5
  • 17
    • 0025103799 scopus 로고
    • Competitive interaction of cyclosporins with the Vinca alkaloid-binding site of P-glycoprotein in multidrug resistant cells
    • Tamai, I , and Safa, A. R Competitive interaction of cyclosporins with the Vinca alkaloid-binding site of P-glycoprotein in multidrug resistant cells. J. Biol. Chem., 265 16509-16513, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 16509-16513
    • Tamai, I.1    Safa, A.R.2
  • 18
    • 0024371025 scopus 로고
    • The function of GP170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles
    • Kamimoto, Y., Gatmaitan, Z , Hsu, J , and Arias, I M The function of GP170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles. J Biol. Chem., 264: 11693-11698, 1989.
    • (1989) J Biol. Chem. , vol.264 , pp. 11693-11698
    • Kamimoto, Y.1    Gatmaitan, Z.2    Hsu, J.3    Arias, I.M.4
  • 19
    • 0026469337 scopus 로고
    • Modulation of P-glycoprotein-mediated drug transport by alterations in lipid fluidity of rat liver canalicular membrane vesicles
    • Sinicrope, F A., Dudeja, P K., Bissonnette, B. M., Safa, A. R., and Brasitus, T. A. Modulation of P-glycoprotein-mediated drug transport by alterations in lipid fluidity of rat liver canalicular membrane vesicles J. Biol. Chem., 267: 24995-25002, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 24995-25002
    • Sinicrope, F.A.1    Dudeja, P.K.2    Bissonnette, B.M.3    Safa, A.R.4    Brasitus, T.A.5
  • 20
    • 0027450681 scopus 로고
    • Canalicular transport: Discovery of ATP-dependent mechanisms
    • Vore, M. Canalicular transport: discovery of ATP-dependent mechanisms. Toxicol. Appl. Pharmacol., 118: 2-7, 1993.
    • (1993) Toxicol. Appl. Pharmacol. , vol.118 , pp. 2-7
    • Vore, M.1
  • 21
    • 0027299120 scopus 로고
    • Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates
    • Schrenk, D , Gant, T. W., Preisegger, K-H , Silverman, J A., Marino, P. A , and Thorgeirsson, S. S. Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates. Hepatology, 17: 854-860, 1993.
    • (1993) Hepatology , vol.17 , pp. 854-860
    • Schrenk, D.1    Gant, T.W.2    Preisegger, K.-H.3    Silverman, J.A.4    Marino, P.A.5    Thorgeirsson, S.S.6
  • 22
    • 0027254929 scopus 로고
    • Cyclosporin, the biology of the bile canaliculus and cholestasis
    • Arias, I. M. Cyclosporin, the biology of the bile canaliculus and cholestasis Gastroenterology, 104: 1558-1559, 1993
    • (1993) Gastroenterology , vol.104 , pp. 1558-1559
    • Arias, I.M.1
  • 24
    • 0000622931 scopus 로고
    • Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil
    • Safa, A. R. Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil. Proc. Natl. Acad. Sci. USA, 85: 7187-7191, 1988.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 7187-7191
    • Safa, A.R.1
  • 25
    • 0025325040 scopus 로고
    • Reversal of the multidrug resistance phenorype with Cremophor EL, a common vehicle for water-insoluble vitamins and drugs
    • Woodcock, D. M., Jefferson, S., Linsenmeyer, M. E., Crouther, P. J., Chojnowski, G. M., Williams, B., and Bertoncello, I. Reversal of the multidrug resistance phenorype with Cremophor EL, a common vehicle for water-insoluble vitamins and drugs. Cancer Res., 50: 4199-4203, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 4199-4203
    • Woodcock, D.M.1    Jefferson, S.2    Linsenmeyer, M.E.3    Crouther, P.J.4    Chojnowski, G.M.5    Williams, B.6    Bertoncello, I.7
  • 27
    • 0028843263 scopus 로고
    • Pharmacological correlation between total drug concentration and lactones of CPT-11 and SN-38 in patients treated with CPT-11
    • Sasaki, Y., Yoshida, Y., Sudoh, X., Hakusui, H., Fujii, H., Ohtsu, T., Wakita, H., Igarashi, T., and Itoh, K. Pharmacological correlation between total drug concentration and lactones of CPT-11 and SN-38 in patients treated with CPT-11. Jpn. J. Cancer Res , 86: 111-116, 1995.
    • (1995) Jpn. J. Cancer Res , vol.86 , pp. 111-116
    • Sasaki, Y.1    Yoshida, Y.2    Sudoh, X.3    Hakusui, H.4    Fujii, H.5    Ohtsu, T.6    Wakita, H.7    Igarashi, T.8    Itoh, K.9
  • 28
    • 0025991731 scopus 로고
    • Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells
    • Tamai, I., and Safa, A. R. Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells J. Biol. Chem , 266: 16796-16800, 1991.
    • (1991) J. Biol. Chem , vol.266 , pp. 16796-16800
    • Tamai, I.1    Safa, A.R.2
  • 29
    • 0002811678 scopus 로고
    • Cyclosporin
    • W. E. Evans, J. J. Schentag, and W. J. Jusko (eds.), Vancouver, British Columbia: Applied Therapeutics, Inc.
    • Yee, G. C., and Salomon, D. R Cyclosporin. In: W. E. Evans, J. J. Schentag, and W. J. Jusko (eds.), Applied Pharmacokinetics: Principles of Therapeutic Drug Monitoring, pp. 28-1-28-40. Vancouver, British Columbia: Applied Therapeutics, Inc., 1992.
    • (1992) Applied Pharmacokinetics: Principles of Therapeutic Drug Monitoring , pp. 281-2840
    • Yee, G.C.1    Salomon, D.R.2
  • 30
    • 0025787254 scopus 로고
    • Investigations on the metabolic pathways of cyclosporine. I. Excretion of cyclosporin and its metabolites in human bile: Isolation of 12 new cyclosporine metabolites
    • Christians, U., Strohmeyer, S., Kownatzki, R., Schiebel, H-M , Bleck, J , Greipel, J., Kohlhaw, K., Schottmann, R., and Sewing, K-F. Investigations on the metabolic pathways of cyclosporine. I. Excretion of cyclosporin and its metabolites in human bile: isolation of 12 new cyclosporine metabolites. Xenobioncs, 21: 1185-1198, 1991.
    • (1991) Xenobioncs , vol.21 , pp. 1185-1198
    • Christians, U.1    Strohmeyer, S.2    Kownatzki, R.3    Schiebel, H.-M.4    Bleck, J.5    Greipel, J.6    Kohlhaw, K.7    Schottmann, R.8    Sewing, K.-F.9
  • 31
    • 0025868320 scopus 로고
    • Investigations on the metabolic pathways of cyclosporine, II. Elucidation of the metabolic pathways in vitro by human liver microsomes
    • Christians, U., Strohmeyer, S., Kownatzki, R., Schiebel, H-M., Bleck, J., Kohlhaw, K , Schottmann, R., and Sewing, K-F. Investigations on the metabolic pathways of cyclosporine, II. Elucidation of the metabolic pathways in vitro by human liver microsomes. Xenobiotics, 21: 1199-1210, 1991.
    • (1991) Xenobiotics , vol.21 , pp. 1199-1210
    • Christians, U.1    Strohmeyer, S.2    Kownatzki, R.3    Schiebel, H.-M.4    Bleck, J.5    Kohlhaw, K.6    Schottmann, R.7    Sewing, K.-F.8
  • 32
    • 0028989171 scopus 로고
    • Identification and kinetics of a β-glucuronide metabolite of SN-38 in human plasma after administration of the camptothecin derivative irinotecan
    • Rivory, L P., and Robert, J. Identification and kinetics of a β-glucuronide metabolite of SN-38 in human plasma after administration of the camptothecin derivative irinotecan Cancer Chemother. Pharmacol., 36: 176-179, 1995.
    • (1995) Cancer Chemother. Pharmacol. , vol.36 , pp. 176-179
    • Rivory, L.P.1    Robert, J.2
  • 33
    • 0028937909 scopus 로고
    • The important role of albumin in determining the relative human blood stabilities of the camptothecin anticancer drugs
    • Burke, T G., Munshi, C. B , Mi, Z., and Jiang, Y The important role of albumin in determining the relative human blood stabilities of the camptothecin anticancer drugs. J. Pharm Sci , 84: 518-519, 1995.
    • (1995) J. Pharm Sci , vol.84 , pp. 518-519
    • Burke, T.G.1    Munshi, C.B.2    Mi, Z.3    Jiang, Y.4
  • 34
    • 8944260075 scopus 로고
    • The pivotal role of albumin in determining the relative blood stabilities of camptothecin analogs presently in clinical trials
    • Burke, T., Mi, Z., Roy, D , and Munshi, C The pivotal role of albumin in determining the relative blood stabilities of camptothecin analogs presently in clinical trials Proc Am. Soc. Clin. Oncol., 14: 463, 1995.
    • (1995) Proc Am. Soc. Clin. Oncol. , vol.14 , pp. 463
    • Burke, T.1    Mi, Z.2    Roy, D.3    Munshi, C.4
  • 35
    • 0025887582 scopus 로고
    • Factors influencing the pharmacokinetics of cyclosporine in man
    • Lindholm, A. Factors influencing the pharmacokinetics of cyclosporine in man. Ther. Drug Monit., 13: 465-477, 1991.
    • (1991) Ther. Drug Monit. , vol.13 , pp. 465-477
    • Lindholm, A.1
  • 36
    • 0020963903 scopus 로고
    • Physiologically based pharmacokinetic modeling: Principles and applications
    • Gerlowski, L. E., and Jain, R. K. Physiologically based pharmacokinetic modeling: principles and applications. J. Pharm. Sci., 72: 1103-1127, 1983.
    • (1983) J. Pharm. Sci. , vol.72 , pp. 1103-1127
    • Gerlowski, L.E.1    Jain, R.K.2
  • 37
    • 0021804301 scopus 로고
    • Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport
    • Jansenm P. L. M., Peters, W. H., and Lamers, W H. Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport. Hepatology, 5: 573-579, 1985.
    • (1985) Hepatology , vol.5 , pp. 573-579
    • Jansenm, P.L.M.1    Peters, W.H.2    Lamers, W.H.3
  • 39
  • 40
    • 0028284238 scopus 로고
    • Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver
    • Bohme, M., Muller, M., Leier, L. Jedlitschky, G., aad Keppler, D. Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver. Gastroenterology, 107: 255-265, 1994
    • (1994) Gastroenterology , vol.107 , pp. 255-265
    • Bohme, M.1    Muller, M.2    Leier, L.3    Jedlitschky, G.4    Keppler, D.5
  • 43
    • 0028206382 scopus 로고
    • Dosing time-dependent nephrotoxicity of cyclosporin A during 21-day administration to Wistar rats
    • Batalla, A., Malmary, M. F , Cambar, J., Labat, C., and Oustrin, J Dosing time-dependent nephrotoxicity of cyclosporin A during 21-day administration to Wistar rats Chronobiol. Int., 11: 187-195, 1994.
    • (1994) Chronobiol. Int. , vol.11 , pp. 187-195
    • Batalla, A.1    Malmary, M.F.2    Cambar, J.3    Labat, C.4    Oustrin, J.5


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