Structural basis of BMP signalling inhibition by the cystine knot protein Noggin

Nature

Volumn 420, Issue 6916, 2002, Pages 636-642

  Groppe, Jay ^a,c   Greenwald, Jason ^a   Wiater, Ezra ^a   Rodriguez Leon, Joaquin ^b   Economides, Aris N ^d   Kwiatkowski, Witek ^a   Affolter, Markus ^c   Vale, Wylie W ^a   Izpisua Belmonte, Juan Carlos ^a,b   Choe, Senyon ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b Instituto Gulbenkian de Ciencia ^*  (Portugal)

^c UNIVERSITY OF BASEL   (Switzerland)

^d REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; BRAIN; CELLS; CRYSTAL STRUCTURE; GENES; TOPOLOGY;

CELLULAR PROCESSES;

PROTEINS;

BONE MORPHOGENETIC PROTEIN; CYSTEINE; CYSTINE; EPITOPE; LIGAND; NOGGIN; OSTEOGENIC PROTEIN 1; RECEPTOR SUBTYPE; BONE MORPHOGENETIC PROTEIN RECEPTOR; CARRIER PROTEIN; CELL SURFACE RECEPTOR; GROWTH FACTOR RECEPTOR; NOGGIN PROTEIN; PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

PROTEIN; SIGNALING;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; BONE DEVELOPMENT; CHICKEN; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; EMBRYO DEVELOPMENT; HUMAN; LIMB DEVELOPMENT; MOLECULAR EVOLUTION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR BINDING; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CHICK EMBRYO; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; LIMB BUD; METABOLISM; MOLECULAR GENETICS; MUTATION; PRENATAL DEVELOPMENT; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; X RAY CRYSTALLOGRAPHY;

ANIMALIA; GALLUS GALLUS;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BONE MORPHOGENETIC PROTEIN RECEPTORS; BONE MORPHOGENETIC PROTEINS; CARRIER PROTEINS; CHICK EMBRYO; CRYSTALLOGRAPHY, X-RAY; CYSTINE; HUMANS; LIGANDS; LIMB BUD; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, GROWTH FACTOR; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 0037069653     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01245     Document Type: Article

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