An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity

Oncogene

Volumn 22, Issue 7, 2003, Pages 1057-1069

  Xiao, Zhan ^a   Latek, Robert ^a   Lodish, Harvey F ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Co Smad; Importin ; Nuclear localization signal (NLS); Nucleo cytoplasmic shuttling; R Smads

Indexed keywords

HYBRID PROTEIN; SMAD PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; DNA BINDING; GENE TARGETING; GENETIC TRANSCRIPTION; MUTATION; NUCLEAR IMPORT; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; CELL LINE; CELL NUCLEUS; DNA; DNA-BINDING PROTEINS; HUMANS; KIDNEY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 0037455715     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206212     Document Type: Article

References (21)

1. de Caestecker MP, Yahata T, Wang D, Parks WT, Huang S, Hill CS, Shioda T, Roberts AB and Lechleider RJ. (2000). J. Biol. Chem., 275, 2115-2122.
2. Conti E, Uy M, Leighton L, Blobel G and Kuriyan J. (1998). Cell, 94, 193-204.
3. Gorlich D and Mattaj IW. (1996). Science, 271, 1513-1518.
4. Hanyu A, Ishidou Y, Ebisawa T, Shimanuki T, Imamura T and Miyazono K. (2001). J. Cell Biol., 155, 1017-1027.
5. Jones JB and Kern SE. (2000). Nucleic Acids Res., 28, 2363-2368.
6. Kobe B. (1999). Nat. Struct. Biol., 6, 388-397.
7. Kurisaki A, Kose S, Yoneda Y, Heldin CH and Moustakas A. (2001). Mol. Biol. Cell., 12, 1079-1091.
8. Liu F, Pouponnot C and Massague J. (1997). Genes Dev. 11, 3157-3167.
9. Massague J and Wotton D. (2000). EMBO J., 19, 1745-1754.
10. Moren A, Itoh S, Moustakas A, Dijke P and Heldin CH. (2000). Oncogene, 19, 4396-4404.
11. Nicols A, Sharkp KA and Honig B. (1991). Proteins, 11, 140-163.
12. Pierreux CE, Nicolas FJ and Hill CS. (2000). Mol. Cell. Biol., 20, 9041-9054.
13. Sali A and Blundell T. (1993). J. Mol. Biol., 234, 779-815.
14. Sekimoto T, Imamoto N, Nakajima K, Hirano T and Yoneda Y. (1997). EMBO J., 16, 7067-7077.
15. Shi Y, Wang YF, Jayaraman L, Yang H, Massague J and Pavletich NP. (1998). Cell, 94, 585-594.
16. Watanabe MN, Masuyama M, Fukuda K and Nishida E. (2000). EMBO Rep., 1, 176-182.
17. Wu RY, Zhang Y, Feng XH and Derynck R. (1997). Mol. Cell Biol., 17, 2521-2528.
18. Xiao Z, Liu X, Henis YI and Lodish HF. (2000a). Proc. Natl. Acad. Sci. USA, 97, 7853-7858.
19. Xiao Z, Liu X and Lodish HF. (2000b). J. Biol. Chem., 275, 23425-23428.
20. Xu J and Attisano L. (2000). Proc. Natl. Acad. Sci. USA, 97, 4820-4825.
21. Ying X and Dong X. (2000). Proteins: Struct. Function Genet., 40, 343-354.