Balancing the activation state of the endothelium via two distinct TGF-β type I receptors

EMBO Journal

Volumn 21, Issue 7, 2002, Pages 1743-1753

  Goumans, Marie José ^a   Valdimarsdottir, Gudrun ^a   Itoh, Susumu ^a   Rosendahl, Alexander ^a   Sideras, Paschalis ^a   Ten Dijke, Peter ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

ALK; Angiogenesis; Signal transduction; Smad; TGF

Indexed keywords

PLASMINOGEN ACTIVATOR INHIBITOR 1; SMAD PROTEIN; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD5 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR SYSTEM; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM; GENE INDUCTION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; CATTLE; CELL DIVISION; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HELIX-LOOP-HELIX MOTIFS; INHIBITOR OF DIFFERENTIATION PROTEIN 1; KINETICS; PHOSPHOPROTEINS; PHOSPHORYLATION; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD5 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3;

ANIMALIA;

EID: 0037007226     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.7.1743     Document Type: Article

References (49)

1. Transforming growth factor β1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma
2. Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors
3. Differential modulation of vascular cell integrin and extracellular matrix expression in vitro by TGF-β correlates with reciprocal effects on cell migration
4. Over-expression of endoglin (CD105): A marker of breast carcinoma-induced neo-vascularization
5. Mechanisms of angiogenesis and arteriogenesis
6. Smad1 recognition and activation by the ALK1 group of transforming growth factor-β family receptors
7. Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type I gene
8. Smads: Transcriptional activators of TGF-β responses
9. Transforming growth factor β1 induces angiogenesis in vivo with a threshold pattern
10. Blood vessel formation: What is its molecular basis?
11. Basic fibroblast growth factor and transforming growth factor β-1: Synergistic mediators of angiogenesis in vitro
12. Functional analysis of the TGFβ receptor/Smad pathway through gene ablation in mice
13. Transforming growth factor-β signalling in extraembryonic mesoderm is required for yolk sac vasculogenesis in mice
14. PDGF, TGF-β and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of I0T1/2 cells and their differentiation to a smooth muscle fate
15. Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells
16. Endothelial cells exhibiting angiogenesis in vitro proliferate in response to TGF-β1
17. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2
18. Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-β, activin and bone morphogenetic protein-inducible enhancer
19. Targeted expression of transforming growth factor-β1 in intracardiac grafts promotes vascular endothelial cell DNA synthesis
20. Identification and functional characterization of distinct critically important BMP-specific response elements in the Id1 promoter
21. Abnormal angiogenesis but intact hematopoietic potential in TGF-β type I receptor-deficient mice
22. Role of endoglin in cellular responses to transforming growth factor-β. A comparative study with β-glycan
23. CD105 antagonizes the inhibitory signaling of transforming growth factor β1 on human vascular endothelial cells
24. A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells
25. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts
26. Modulation of vascular cell behavior by transforming growth factors β
27. TGF-β signal transduction
28. Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
29. Inhibitory action of transforming growth factor β on endothelial cells
30. TGF-β receptor-mediated signalling through Smad2, Smad3 and Smad4
31. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis
32. Activin receptor-like kinase I modulates transforming growth factor-β1 signaling in the regulation of angiogenesis
33. Transforming growth factor-β: Vasculogenesis, angiogenesis and vessel wall integrity
34. Biphasic effect of transforming growth factor-β1 on in vitro angiogenesis
35. The L45 loop in type I receptors for TGF-β family members is a critical determinant in specifying Smad isoform activation
36. Transforming growth factor β-1 positively modulates the bioactivity of fibroblast growth factor on corneal endothelial cells
37. Mechanisms of angiogenesis
38. Transforming growth factor type β: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
39. Activation of the TGF-β/activin-Smad2 pathway during allergic airway inflammation
40. Inhibition of endothelial cell movement by pericytes and smooth muscle cells: Activation of a latent transforming growth factor-β1-like molecule by plasmin during co-culture
41. Regulation of type I plasminogen activator inhibitor gene expression in cultured bovine aortic endothelial cells. Induction by transforming growth factor-β, lipopolysaccharide and tumor necrosis factor-α
42. The serpin PAI-1 inhibits cell migration by blocking integrin αVβ3 binding to vitronectin
43. Inhibition of angiogenesis in vivo by plasminogen activator inhibitor-1
44. Intracellular signaling of osteogenic protein-1 through Smad5 activation
45. Characterization of type I receptors for transforming growth factor-β and activin
46. Transcription of the dominant-negative helix-loop-helix protein Id1 is regulated by a protein complex containing the immediate-early response gene Egr-1
47. Arteriovenous malformations in mice lacking activin receptor-like kinase-1
48. A novel, quantitative model for study of endothelial cell migration and sprout formation within three-dimensional collagen matrices
49. Transforming growth factor β1-induced changes in cell migration, proliferation and angiogenesis in the chicken chorioallantoic membrane