The crystal structure of TGF-β3 and comparison to TGF-β2: Implications for receptor binding

Protein Science

Volumn 5, Issue 7, 1996, Pages 1261-1271

  Mittl, Peer R E ^a   Priestle, John P ^a   Cox, David A ^a   Mcmaster, Gary ^a   Cerletti, Nico ^a   Grütter, Markus G ^a  

^a CIBA GEIGY LTD   (Switzerland)

Author keywords

crystal contact; dioxane; proteoglycan; receptor recognition; TGF

Indexed keywords

ALANINE; CYTOKINE; DIOXANE; LEUCINE; PROLINE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; TRYPTOPHAN; VALINE;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HYDROGEN BOND; MUTATION; PRIORITY JOURNAL; RECEPTOR BINDING; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

EID: 0029943464     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560050705     Document Type: Article

References (48)

1. 77] transforming growth factor-β1. J Biol Chem 269:27681-27691.
2. Archer SJ, Bax A, Roberts AB, Sporn MB, Ogawa Y, Piez KA, Weatherbee JA, Tsang MLS, Lucas R, Zheng BL, Wenker J, Torchia DA. 1993. Transforming growth factor-β1: Secondary structure as determined by heteronuclear magnetic resonance spectroscopy. Biochemistry 32:1164-1171.
3. Attisano L, Wrana JL, López-Casillas F, Massagué J. 1994. TGF-β receptors and action. Biochim Biophys Acta 1222:71-80.
4. Brunger AT. 1990. Extension of molecular replacement: A new search strategy based on Patterson correlation refinement. Acta Crystallogr A 46:46-57.
5. Brünger AT, Kuriyan J, Karplus M. 1987. Crystallographic R-factor refinement by molecular replacement. Science 235:458-460.
6. Burt DW. 1992. Evolutionary grouping of the transforming growth factor-β superfamily. Biochem Biophys Res Commun 184:590-595.
7. CCP4. 1994. Collaborative Computational Project, No. 4. The CCP4 suite: Programs for protein crystallography. Acta Crystallogr D 50:760-763.
8. Cerletti N. 1995. Novel process for the production of biologically active dimeric protein. PCT Appl. No. EP 95/02718.
9. Chothia C, Lesk AM. 1987. The evolution of protein structures. Cold Spring Harbor Symp Quant Biol 52:399-405.
10. Clackson T, Wells JA. 1995. A hot spot of binding energy in a hormone-receptor interface. Science 267:383-386.
11. Cox DA. 1995. Transforming growth factor-beta 3. Cell Biol Int 19:357-371.
12. Cunningham BC, Wells JA. 1993. Comparison of a structural and a functional epitope. J Mol Biol 234:554-563.
13. Daopin S, Davies D, Schlunegger MP, Grutter MG. 1994. Comparison of two crystal structures of TGF-β2: The accuracy of refined protein structures. Acta Crystallogr D 50:85-92.
14. Daopin S, Li M, Davies DR. 1993. Crystal structure of TGF-β2 refined at 1.8 Å resolution. Proteins Struct Funct Genet 17:176-192.
15. Daopin S, Piez KA, Ogawa Y, Davies DR. 1992. Crystal structure of transforming growth factor-β2: An unusual fold for the superfamily. Science 257:369-373.
16. De Vos AM, Ultsch M, Kossiakoff AA 1992. Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex. Science 255:306-312.
17. 2. Mol Endocrinol 3:1977-1986.
18. Hüsken-Hindi P, Tsuchida K, Park M, Corrigan AZ, Vaughan JM, Vale WW, Fischer WH. 1994. Monomeric activin A retains high receptor binding affinity but exhibits low biological activity. J Biol Chem 269:19380-19384.
19. Jancarik J, Kim SH 1991. Sparse matrix sampling: A screening method for crystallization of proteins. J Appl Crystallogr 24:409-411.
20. Jones TA, Zou JY, Cowan SW, Kjeldgaard M. 1991. Improved methods for building protein models in electron density maps and location of errors in these models. Acta Crystallogr A 47:110-119.
21. Kleywegt GJ, Jones TA. 1994. Detection, delineation, measurement and display of cavities in macromolecular structures. Acta Crystallogr D 50: 178-185.
22. Koritsánszky T, Strumpel MK, Buschmann J, Luger P, Hansen NK, Pichon-Pesme V. 1991. A study of the anomeric effect on an electronic scale: The electron density of 1,4-dioxane and trans-2,5-dichloro-1,4-dioxane. J Am Chem Soc 113:9148-9154.
23. Kraulis P. 1991. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures. J Appl Crystallogr 24:946-950.
24. Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW. 1994. Crystal structure of human chorionic gonadotropin. Nature 369:455-461.
25. Laskowski RA, MacArthur MW, Moss DS, Thornton JM. 1993. PROCHECK: A program to check the stereochemical quality of protein structures. J Appl Crystallogr 26:282-291.
26. Lawson DW, Artymiuk PJ, Yewdall SJ, Smith JMA, Livinston JC, Treffry A, Luzzago A, Levi S, Arosio P, Cesareni G, Thomas CD, Shaw WV, Harrison PM. 1991. Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts. Nature 349:541-544.
27. Lee B, Richards FM. 1971. The interpretation of protein structures: Estimation of static accessibility. J Mol Biol 55:379-384.
28. Lin HY, Moustakas A, Knaus P, Wells RG, Henis YI, Lodish HF. 1995. The soluble exoplasmic domain of type II transforming growth factor (TGF)-β receptor. J Biol Chem 270:2747-2754.
29. Lin HY, Wang YF, Ng-Eaton E, Weinberg R, Lodish H. 1992. Expression cloning of the TGF-ß type II receptor, a functional transmembrane serine/threonine kinase. Cell 68:775-785.
30. López-Casillas F, Cheifetz S, Doody J, Andres JL, Lane WS, Massagué J. 1991. Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system. Cell 67:785-795.
31. López-Casillas F, Wrana JL, Massagué J. 1993. Betaglycan presents ligand to the TGF-β signalling receptor. Cell 73:1435-1444.
32. Luzzati PV. 1952. Traitment statistique des erreurs dans la détermination des structures cristallines. Acta Crystallogr 5:802-810.
33. Massagué J. 1990. The transforming growth factor-β family. Annu Rev Cell Biol 6:597-641.
34. Matthews BW. 1968. X-ray structure of proteins. J Mol Biol 33:461-467.
35. Murray-Rust J, McDonald NQ, Blundell TL, Hosang M, Oefner C, Winkler F, Bradshaw RA. 1993. Topological similarities in TGF-β2, PDGF-BB and NGF define a superfamily of polypeptide growth factors. Structure 1:153-159.
36. Pflugrath JW, Messerschmidt A. 1987. Crystal orientation and X-ray pattern prediction of area-detector diffractometer systems in macromolecular crystallography. Acta Crystallogr 20:306-315.
37. Qian SW, Burmester JK, Sun PD, Huang A, Ohlsen DL, Suardet L, Flanders KC, Davies D, Robets AB, Sporn B. 1994. Characterization of mutated transforming growth factor-βs which possess unique biological properties. Biochemistry 33:12298-12304.
38. Roberts AB, Sporn MB. 1990. The transforming growth factor-βs. In: Sporn MB, Roberts AB, eds. Peptide growth factors and their receptors I. Berlin: Springer-Verlag, pp 419-472.
39. Schlunegger MP, Grütter MG. 1992. An unusual feature revealed by the crystal structure at 2.2 Å resolution of human transforming growth factor-β2. Nature 358:430-434.
40. Schlunegger MP, Grütter MG. 1993. Refined crystal structure of human transforming growth factor-β2 at 1.95 Å resolution. J Mol Biol 231: 445-458.
41. Sibanda BL, Blundell TL, Thornton JM. 1989. Conformation of β-hairpins in protein structures. J Mol Biol 206:759-777.
42. Suzuki A, Shioda N, Maeda T, Tada M, Ueno N. 1994. Cloning of an mouse TGF-β type II receptor gene. FEBS Let 355:19-22.
43. Takahashi T, Endo S, Nagayama K. 1993. Stabilization of protein crystals by electrostatic interactions as revealed by a numerical approach. J Mol Biol 234:421-432.
44. Vyas NK. 1991. Atomic features of protein-carbohydrate interactions. Curr Optn Struct Biol 1:732-740.
45. Wang XF, Lin HY, Ng-Eaton E, Downward J, Lodish HF, Weinberg RA. 1991. Expression cloning and characterization of the TGF-β type III receptor. Cell 67:797-805.
46. Wlodawer A. 1984. Structure of bovine pancreatic trypsin inhibitor: Results of joint neutron and X-ray refinement of crystal form II. J Mol Biol 180: 301-329.
47. Wrana JL, Attisano L, Wieser R, Ventura F, Massagué J. 1994. Mechanism of activation of the TGF-β receptor. Nature 370:341-347.
48. Yamashita H, ten Dijke P, Franzén P, Miyazono K, Heldin CH. 1994. Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-β. J Biol Chem 269:20172-20178.