TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G1 arrest

Genes and Development

Volumn 14, Issue 24, 2000, Pages 3093-3101

  Petritsch, Claudia ^a,b   Beug, Hartmut ^a   Baimain, Allan ^b   Oft, Martin ^b  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cell cycle; G1 arrest; PP2A; TGF p70s6k

Indexed keywords

PHOSPHOPROTEIN PHOSPHATASE 2A; S6 KINASE; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BREAST EPITHELIUM; ENZYME INACTIVATION; ENZYME SUBUNIT; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

ACTIVIN RECEPTORS, TYPE I; ANDROSTADIENES; ANIMALS; CELLS, CULTURED; CHROMONES; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EPITHELIAL CELLS; FIBROBLASTS; G1 PHASE; MORPHOLINES; MUTATION; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN-SERINE-THREONINE KINASES; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RIBOSOMAL PROTEIN S6 KINASES; S PHASE; SIGNAL TRANSDUCTION; SIROLIMUS; SMAD2 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034671578     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.854200     Document Type: Article

References (36)

1. Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells
2. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation
3. Mechanism of TGF-β receptor inhibition by FKBP12
4. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
5. Targeted disruption of Smad3 reveals an essential role in transforming growth factor β-mediated signal transduction
6. Cell cycle regulation of p70 S6 kinase and p42/p44 mitogen-activated protein kinases in Swiss mouse 3T3 fibroblasts
7. MADR2 maps to 18q21 and encodes a TGF-β-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
8. Protein phosphatase 2A: Who shall regulate the regulator?
9. Physical and functional interactions between type I transforming growth factor β receptors and bα, a WD-40 repeat subunit of phosphatase 2A
10. Crystal structure of the cytoplasmic domain of the type I TGF β receptor in complex with FKBP12
11. Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family
12. Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
13. p70s6k function is essential for G1 progression
14. The antiproliferative effect of type β transforming growth factor occurs at a level distal from receptors for growth-activating factors
15. Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells
16. MADR2 is a substrate of the TGF-β receptor and its phosphorylation is required for nuclear accumulation and signaling
17. Controlling TGF-β signaling
18. Regulation of protein kinase cascades by protein phosphatase 2A
19. Identification of Smad2, a human Mad-related protein in the transforming growth factor β signaling pathway
20. Production of high-titer helper-free retroviruses by transient transfection
21. Regulation of p70s6k/p85s6k and its role in the cell cycle
22. Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein
23. Activation of p70 S6 kinase and erk-encoded mitogen-activated protein kinases is resistant to high cyclic nucleotide levels in Swiss 3T3 fibroblasts
24. Phosphorylation and activation of p70s6k by PDK1
25. Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion
26. Role of PP2A in intracellular signal transduction pathways
27. Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-β signaling
28. Signaling inputs converge on nuclear effectors in TGF-β signaling
29. Alterations of the PPP2R1B gene in human lung and colon cancer
30. Specific interaction of type I receptors of the TGF-β family with the immunophilin FKBP-12
31. The immunophilin FKBP12 functions as a common inhibitor of the TGF β family type I receptors
32. Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies
33. The Smad pathway
34. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β
35. Receptor-associated Mad homologues synergize as effectors of the TGF-β response
36. Smad3 mutant mice develop metastatic colorectal cancer