Apaf-1 is a transcriptional target for E2F and p53

Nature Cell Biology

Volumn 3, Issue 6, 2001, Pages 552-558

  Moroni, M Cristina ^a   Hickman, Emma S ^a   Denchi, Eros Lazzerini ^a   Caprara, Greta ^a   Colli, Elena ^a   Cecconi, Francesco ^b,c   Müller, Heiko ^a,d   Helin, Kristian ^a  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS PROTEASE ACTIVATING FACTOR 1; HOLOENZYME; MESSENGER RNA; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER; CANCER CHEMOTHERAPY; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN TARGETING; TUMOR CELL;

ANIMALS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; EMBRYO; HUMANS; MICE; PROMOTER REGIONS (GENETICS); PROTEINS; RETINOBLASTOMA PROTEIN; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034977277     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35078527     Document Type: Article

References (38)

1. Cancer cell cycles
2. The hallmarks of cancer
3. The retinoblastoma gene family in differentiation and development
4. The regulation of E2F by pRB-family proteins
5. The E2F transcription factors: Key regulators of cell proliferation
6. p53 and E2F-1 cooperate to mediate apoptosis
7. Deregulated E2F1 expression leads to S-phase entry and p53-mediated apoptosis
8. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis
9. E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction
10. E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis
11. Induction of DNA synthesis and apoptosis are separable functions of E2F-1
12. E2F-1 induced p53-independent apoptosis in transgenic mice
13. CDC25A phosphatase is a target of E2F and is required for efficient E2F-1 induced S phase
14. Role for the p53 homologue p73 in E2F-1-induced apoptosis
15. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
16. Mutation of E2F1 suppresses apoptosis and inappropriate S-phase entry and extends survival of Rb-deficient mouse embryos
17. ARF links the tumour suppressors RB and p53
18. Tumor surveillance via ARF-p53 pathway
19. p73 is a human p53-related protein that can induce apoptosis
20. Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage
21. The biochemistry of apoptosis
22. Apaf-1 (CED-4 homolog) regulates programmed cell death in mammalian development
23. Apaf-1 is required for mitochondrial pathways of apoptosis and brain development
24. Apaf-1 and Caspase-9 in p53-dependent apoptosis and tumor inhibition
25. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
26. Caspase-9 and APAF-1 form an active holoenzyme
27. Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or BclXl
28. Overexpression of Apaf-1 promotes apoptosis of untreated and paclitaxel- or etoposide-treated HL-60 cells
29. A matter of life or cell death
30. E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways
31. INK4A, TGFβ and contact inhibition
32. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
33. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
34. HAC-1, a Drosophila homolog of APAF-1 and CED-4, functions in developmental- and radiation-induced apoptosis
35. Regulation of the cyclin E gene by transcription factor E2F1
36. Oncogene-dependent apoptosis is mediated by caspase-9
37. The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
38. In situ hybridization analysis of TGF-β3 expression during mouse development: Comparative studies with TGF-β1 and -β2