Human mdm2 Mediates Multiple Mono-ubiquitination of p53 by a Mechanism Requiring Enzyme Isomerization

Journal of Biological Chemistry

Volumn 276, Issue 33, 2001, Pages 31357-31367

  Lai, Zhihong ^b   Ferry, Katherine V ^a   Diamond, Melody A ^a   Wee, Kevin E ^b   Kim, Young B ^b   Ma, Jianhong ^b   Yang, Tao ^b   Benfield, Pamela A ^a   Copeland, Robert A ^b   Auger, Kurt R ^a  

^a DuPont Pharmaceuticals Company   (United States)

^b DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL MODIFICATION; ENZYME KINETICS; GENES; ISOMERIZATION; PROTEINS;

RECOMBINANT PROTEINS;

BIOCHEMISTRY;

ENZYME; GENE PRODUCT; LACTACYSTIN; LIGASE; PROTEASOME; PROTEIN MDM2; PROTEIN P53; RECOMBINANT PROTEIN; UBIQUITIN; UBIQUITIN CONJUGATED E2 PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; MDM2 PROTEIN, HUMAN; N ETHYLMALEIMIDE; NUCLEAR PROTEIN; ONCOPROTEIN;

ALLOSTERISM; ARTICLE; CONJUGATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ISOMERIZATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ISOMERISM; KINETICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEIN TARGETING; PROTEIN TRANSPORT; RING FINGER DOMAIN; UBIQUITINATION; CHEMISTRY; HUMAN; METABOLISM; PHYSIOLOGY;

ETHYLMALEIMIDE; HUMANS; KINETICS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINS;

EID: 0035903157     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011517200     Document Type: Article

References (47)

1. Lakin, N. D., and Jackson, S. P. (1999) Oncogene 18, 7644-7655
2. Oren, M. (1999) J. Biol. Chem. 274, 36031-36034
3. Freedman, D. A., Wu, L., and Levine, A. J. (1999) Cell. Mol. Life Sci. 55, 96-107
4. Prives, C. (1998) Cell 95, 5-8
5. Kubbutat, M. H., Jones, S. N., and Vousden, K. H. (1997) Nature 387, 299-303
6. Haupt, Y., Maya, R., Kazaz, A., and Oren, M. (1997) Nature 387, 296-299
7. Ashcroft, M., and Vousden, K. H. (1999) Oncogene 18, 7637-7643
8. Fang, S., Jensen, J. P., Ludwig, R. L., Vousden, K. H., and Weissman, A. M. (2000) J. Biol. Chem. 275, 8945-8951
9. Honda, R., and Yasuda, H. (2000) Oncogene 19, 1473-1476
10. Hershko, A., and Ciechanover, A. (1998) Annu. Rev. Biochem. 67, 425-479
11. Kumar, S., Kao, W. H., and Howley, P. M. (1997) J. Biol. Chem. 272, 13548-13554
12. Huibregtse, J. M., Scheffner, M., Beaudenon, S., and Howley, P. M. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 2563-2567
13. Lorick, K. L., Jensen, J. P., Fang, S., Ong, A. M., Hatakeyama, S., and Weissman, A. M. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11364-11369
14. Joazeiro, C. A., Wing, S. S., Huang, H., Leverson, J. D., Hunter, T., and Liu, Y. C. (1999) Science 286, 309-312
15. Saurin, A. J., Borden, K. L., Boddy, M. N., and Freemont, P. S. (1996) Trends Biochem. Sci 21, 208-214
16. Tyers, M., and Willems, A. R. (1999) Science 284, 601, 603-4
17. Joazeiro, C. A., and Weissman, A. M. (2000) Cell 102, 549-552
18. Rolfe, M., Beer-Romero, P., Glass, S., Eckstein, J., Berdo, I., Theodoras, A., Pagano, M., and Draetta, G. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 3264-3268
19. Wee, K. E., Lai, Z., Auger, K. R., Ma, J., Horiuchi, K. Y., Dowling, R. L., Dougherty, C. S., Corman, J. I., Wynn, R., and Copeland, R. A. (2000) J. Protein Chemistry 19, 489-498
20. Honda, R., Tanaka, H., and Yasuda, H. (1997) FEBS Lett. 420, 25-27
21. Haas, A. L., Warms, J. V., Hershko, A., and Rose, I. A. (1982) J. Biol. Chem. 257, 2543-2548
22. Piotrowski, J., Beal, R., Hoffman, L., Wilkinson, K. D., Cohen, R. E., and Pickart, C. M. (1997) J. Biol. Chem. 272, 23712-23721
23. Thrower, J. S., Hoffman, L., Rechsteiner, M., and Pickart, C. M. (2000) EMBO J. 19, 94-102
24. Pickart, C. M. (2000) Trends Biochem. Sci. 25, 544-548
25. Dubiel, W., and Gordon, C. (1999) Curr. Biol. 9, R554-R557
26. Scherer, D. C., Brockman, J. A., Chen, Z., Maniatis, T., and Ballard, D. W. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 11259-11263
27. Wu, K., Fuchs, S. Y., Chen, A., Tan, P., Gomez, C., Ronai, Z., and Pan, Z. Q. (2000) Mol. Cell. Biol. 20, 1382-1393
28. Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., and Vogelstein, B. (1998) Science 282, 1497-1501
29. Segel, I. H. (1975) Enzyme Kinetics, Wiley, New York
30. Buschmann, T., Fuchs, S. Y., Lee, C. G., Pan, Z. Q., and Ronai, Z. (2000) Cell 101, 753-762
31. Rodriguez, M. S., Desterro, J. M., Lain, S., Lane, D. P., and Hay, R. T. (2000) Mol. Cell. Biol. 20, 8458-8467
32. Nakamura, S., Roth, J. A., and Mukhopadhyay, T. (2000) Mol. Cell. Biol. 20, 9391-9398
33. Kubbutat, M. H., Ludwig, R. L., Ashcroft, M., and Vousden, K. H. (1998) Mol. Cell. Biol. 18, 5690-5698
34. Koegl, M., Hoppe, T., Schlenker, S., Ulrich, H. D., Mayer, T. U., and Jentsch, S. (1999) Cell 96, 635-644
35. Hershko, A., and Heller, H. (1985) Biochem. Biophys. Res. Commun. 128, 1079-1086
36. Boyd, S. D., Tsai, K. Y., and Jacks, T. (2000) Nat. Cell Biol. 2, 563-568
37. Geyer, R. K., Yu, Z. K., and Maki, C. G. (2000) Nat. Cell Biol. 2, 569-573
38. Freedman, D. A., and Levine, A. J. (1998) Mol. Cell. Biol. 18, 7288-7293
39. Stommel, J. M., Marchenko, N. D., Jimenez, G. S., Moll, U. M., Hope, T. J., and Wahl, G. M. (1999) EMBO J. 18, 1660-1672
40. Hicke, L. (2001) Nat. Rev. Mol. Cell. Biol. 2, 195-201
41. Robzyk, K., Recht, J., and Osley, M. A. (2000) Science 287, 501-504
42. Kaiser, P., Flick, K., Wittenberg, C., and Reed, S. I. (2000) Cell 102, 303-314
43. Pham, A. D., and Sauer, F. (2000) Science 289, 2357-2360
44. Zheng, N., Wang, P., Jeffrey, P. D., and Pavletich, N. P. (2000) Cell 102, 533-539
45. Seol, J. H., Feldman, R. M., Zachariae, W., Shevchenko, A., Correll, C. C., Lyapina, S., Chi, Y., Galova, M., Claypool, J., Sandmeyer, S., Nasmyth, K., and Deshaies, R. J. (1999) Genes Dev. 13, 1614-1626
46. Kao, W. H., Beaudenon, S. L., Talis, A. L., Huibregtse, J. M., and Howley, P. M. (2000) J. Virol. 74, 6408-6417
47. Strack, P., Caligiuri, M., Pelletier, M., Boisclair, M., Theodoras, A., Beer-Romero, P., Glass, S., Parsons, T., Copeland, R. A., Auger, K. R., Benfield, P., Brizuela, L., and Rolfe, M. (2000) Oncogene 19, 3529-3536