Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

Science

Volumn 274, Issue 5289, 1996, Pages 948-953

  Kussie, Paul H ^a   Gorina, Svetlana ^a   Marechal, Vincent ^b   Elenbaas, Brian ^c   Moreau, Jacque ^d   Levine, Arnold J ^c   Pavletich, Nikola P ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b HÔPITAL ROTHSCHILD   (France)

^c PRINCETON UNIVERSITY   (United States)

^d INSTITUT JACQUES MONOD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; CRYSTAL STRUCTURE; DISEASES; DNA SEQUENCES; GENES;

CANCERS; CELLULAR INHIBITOR; GENE EXPRESSION; ONCOPROTEIN; TUMOR SUPPRESSOR TRANSACTIVATION DOMAIN;

PROTEINS;

DNA; ONCOPROTEIN; PROTEIN P53; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA PROTEIN COMPLEX; GENE AMPLIFICATION; GENE REPRESSION; HUMAN; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; TRANSACTIVATION; TUMOR SUPPRESSOR GENE; XENOPUS LAEVIS;

BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; MODELS, MOLECULAR; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

XENOPUS LAEVIS;

EID: 0030575937     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.274.5289.948     Document Type: Article

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