Guardian ancestry: Fly p53 and damage-inducible apoptosis

Cell Death and Differentiation

Volumn 7, Issue 11, 2000, Pages 1035-1038

  Nordstrom, W ^a   Abrams, J M ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Apoptosis; Drosophila; P53

Indexed keywords

CASPASE; DNA; GLUTAMIC ACID; PROTEIN P53; PROTEIN P73; RETINOBLASTOMA PROTEIN; SERINE;

AMINO TERMINAL SEQUENCE; APOPTOSIS; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE G2 PHASE; CELL DAMAGE; CONTROLLED STUDY; DNA BINDING; DROSOPHILA; ENZYME ACTIVATION; FLY; GENE FUNCTION; GENE OVEREXPRESSION; GENE SEQUENCE; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; IONIZING RADIATION; MULTIGENE FAMILY; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGOMERIZATION; PHYLOGENY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; REVIEW; TUMOR SUPPRESSOR GENE;

DROSOPHILA; MAMMALIA;

EID: 0033694317     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400766     Document Type: Review

References (36)

1. Drosophila p53 binds a damage response element at the locus
2. Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
3. Identification and characterization of a p53 homologue in Drosophila melanogaster
4. Monoallelically expressed gene related to P53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
5. Characterization of gene expression of a p53 homologue in the soft-shell clam (Mya arenaria)
6. Genetic control of programmed cell death in Drosophila
7. Activation of the reaper gene during ectopic cell killing in drosophila
8. The p53-mdm-2 autoregulatory feedback loop
9. WAF1, a potential mediator of p53 tumor suppression
10. An emerging blueprint for apoptosis in Drosophila
11. Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway
12. HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis
13. Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator
14. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID
15. Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function
16. Reaper-induced apoptosis in a vertebrate system
17. Apoptosis induced by Drosophila Reaper and Grim in a human system attenuation by inhibitor of apoptosis proteins (Ciaps)
18. Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity
19. Scythe a novel reaper-binding apoptotic regulator
20. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
21. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
22. Regulation of p53 in response to DNA damage
23. Cyclin-dependent kinases at the G1-S transition of the mammalian cell cycle
24. Uncoupling cell fate determination from patterned cell division in the Drosophila eye
25. The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene
26. Mus304 encodes a novel DMA damage checkpoint protein required during Drosophila development
27. Enhanced phosphorylation of p53 by ATM in response to DNA damage
28. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
29. ATM associates with and phosphorylates p53:mapping the region of interaction
30. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
31. WAF1, a potential mediator of p53 tumor suppression
32. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
33. A model for p53-induced apoptosis
34. Identification and classification of p53-regulated genes
35. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays
36. BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences