Identification of a sequence element from p53 that signals for Mdm2- targeted degradation

Molecular and Cellular Biology

Volumn 20, Issue 4, 2000, Pages 1243-1253

  Gu, Jijie ^a   Chen, Dongli ^a   Rosenblum, Jamie ^a   Rubin, Rachel M ^a   Yuan, Zhi Min ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; PROTEIN MDM2; PROTEIN P53; PROTEIN P73;

AMINO ACID SEQUENCE; ARTICLE; CHIMERA; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TARGETING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

BINDING SITES; CELL LINE; DNA-BINDING PROTEINS; DRUG STABILITY; GENES, P53; GENES, TUMOR SUPPRESSOR; HALF-LIFE; HUMANS; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0033956689     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.4.1243-1253.2000     Document Type: Article

References (38)

1. Ashcroft, M., M. H. Kubbutat, and K. H. Vousden. 1999. Regulation of p53 function and stability by phosphorylation. Mol. Cell. Biol. 19:1751-1758.
2. Barak, Y. M., T. Juven, R. Haffner, and M. Oren. 1993. Mdm2 expression is induced by wild type p53 activity. EMBO J. 12:461-468.
3. Blattner, C., E. Tobiasch, M. Litfen, H. J. Rahmsdorf, and P. Herrlich. 1999. DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation. Oncogene 18:1723-1732.
4. Chen, J. V. Marechal, and A. J. Levine. 1993. Mapping of the p53 and mdm2 interaction domains. Mol. Cell. Biol. 13:4107-4114.
5. 1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol. Cell. Biol. 16:2445-2452.
6. Chen, J., J. Lin, and A. J. Levine. 1995. Regulation of transcription function of the p53 tumor suppressor by the mdm-2 oncogene. Mol. Med. 1:142-152.
7. Chen, X., L. J. Ko, L. Jayaraman, and C. Prives. 1996. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev. 10:2438-2451.
8. Davison, T. S., C. Vagner, M. Kaghad, A. Ayed, D. Caput, and C. H. Arrow-smith. 1999. p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53. J. Biol. Chem. 274:18709-18714.
9. Dobbelstein, M., S. Wienzek, C. Konig, and J. Roth. 1999. Inactivation of the p53-homologue p73 by the mdm2-oncoprotein. Oncogene 18:2101-2106.
10. Fu, L., and S. Benchimol. 1997. Participation of the human p53 3′ UTR translational repression and activation following gamma-irradiation. EMBO J. 16:4117-4125.
11. Gottleib, T. M., and M. Oren. 1995. p53 in growth control and neoplasia. Biochim. Biophys. Acta 1287:77-102.
12. Haupt, Y., R. Maya, A. Kazaz, and M. Oren. 1997. Mdm2 promotes the rapid degradation of p53. Nature 387:296-299.
13. Honda, R., H. Tanaka, and H. Yasuda. 1997. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420:25-27.
14. Hupp, T. R., D. W. Meek, C. A. Midgley, and D. P. Lane. 1993. Activation of the cryptic DNA binding function of mutant forms of p53. Nucleic Acids Res. 21:3167-3174.
15. Hupp, T. R., A. Sparks, and D. P. Lane. 1995. Small peptides activate the latent sequence-specific DNA binding function of p53. Cell 83:237-245.
16. Jones, S. N., A. E. Roe, L. A. Donehower, and A. Bradley. 1995. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378: 206-208.
17. Jost, C., M. Martin, and W. G. Kaelin. 1997. P73 is a human p53-related protein that can induce apoptosis. Nature 389:191-194.
18. Kaghad, M. H. Bonnet, A. Yang, L. Creancier, J. C. Biscan, A. Valent, A. Minty, P. Chalon, J.-M. Llias, X. Damont, P. Ferrara, F. McKeon, and D. Caput. 1997. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 90:809-819.
19. Kastan, M. B., O. Onyekwere, D. Sidransky, B. Vogelstein, and R. W. Craig. 1991. Participation of p53 in the cellular response to DNA damage. Cancer Res. 51:6304-6311.
20. Kern, S. E., J. A. Pietenpol, S. Thiagalingam, A. Seymour, K. W. Kinzler, and B. Vogelstein. 1992. Oncogenetic forms of p53 inhibit p53-regulated gene expression. Science 256:827-829.
21. Ko, L. J., and C. Prives. 1996. p53: puzzle and paradigm. Genes Dev. 10:1054-1072.
22. Kubbutat, M. H., S. N. Jones, and K. H. Vousden. 1997. Regulation of p53 stability by Mdm2. Nature 387:299-303.
23. Kubbutat, M. H. G., R. L. Ludwig, M. Ashcroft, and K. H. Vousden. 1998. Regulation of Mdm2-directed degradation by the C terminus of p53. Mol. Cell. Biol. 18:5690-5698.
24. Levine, A. J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
25. Maki, C. G., and P. M. Howley. 1997. Ubiquitination of p53 and p21 is differentially affected by ionizing radiation and UV radiation. Mol. Cell. Biol. 17:355-363.
26. Maki, C. G., J. M. Huibregtse, and P. M. Howley. 1996. In vivo ubiquitination and proteasome-mediated degradation of p53(1). Cancer Res. 56:2649-2654.
27. Maltzman, W., and L. Czyzyk. 1984. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol. Cell. Biol. 4:1689-1694.
28. Midgley, C. A., and D. P. Lane. 1997. p53 protein stability in tumor cells is not determined by mutation but is dependent on Mdm2 binding. Oncogene 15:1179-1189.
29. Momand, J., G. P. Zambetti, D. C. Olson, D. L. Geoge, and A. J. Levine. 1992. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69:1237-1245.
30. Mosner, J., T. Mummenbrauer, C. Bauer, G. Sczakiel, F. Grosse, and W. Deppert. 1995. Negative feedback regulation of wild-type p53 biosynthesis. EMBO J. 14:4442-4449.
31. Nelson, W. G., and M. Kastan. 1994. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol. Cell. Biol. 14:1815-1823.
32. Oliner, J. D., J. A. Pietenpol, S. Thiagalingam, J. Gyuris, K. W. Kinzler, and B. Vogelstein. 1993. Oncoprotein MDM2 conceals the activation domain of tumor suppressor p53. Nature 362:857-860.
33. Price, B. D., and S. K. Calderwood. 1993. Increased sequence-specific p53-DNA binding activity after DNA damage is attenuated by phorbol esters. Oncogene 8:3055-3062.
34. Sherr, C. J. 1998. Tumor surveillance via the ARF-p53 pathway. Genes Dev. 12:2984-2991.
35. Shieh, S.-Y., M. Ikeda, Y. Taya, and C. Prives. 1997. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91:325-334.
36. Wu, X., J. H. Bayle, D. Olson, and A. J. Levine. 1993. The p53-mdm-2 autoregulatory feedback loop. Genes Dev. 7:1126-1132.
37. Yuan, Z.-M., H. Shioya, T. Ishiko, X. Sun, J. Gu, Y. Y. Huang, H. Lu, S. Kharbanda, R. Weichselbaum, and D. Kufe. 1999. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature 399: 814-817.
38. Zeng, X., L. Chen, C. A. Jost, R. Maya, D. Keller, X. Wang, W. G. Kaelin, Jr., M. Oren, J. Chen, and H. Lu. 1999. MDM2 suppresses p73 function without promoting p73 degradation. Mol. Cell. Biol. 19:3257-3266.